ABSTRACT
The potential of toxic action in rats of orthochlorbenzol sulphochloride, administered intragastrically in single doses and in daily doses included in food, was estimated. Other bioenzymatic parameters of liver function (transaminase, gammaglutamyltransferase, glutamatdehydrogenase etc.), which presented changes in all experiments performed during this investigations, were also analyzed. Based on the obtained results, stop-gap suggestions of maximum admitted concentrations in environmental elements and air at the work places (0.5 mg/cubic meter) were made.
Subject(s)
Herbicides/toxicity , Sulfones/toxicity , Acute Disease , Animals , Chronic Disease , Female , Herbicides/poisoning , Lethal Dose 50 , Liver/drug effects , Liver/enzymology , Liver/pathology , Male , Poisoning/enzymology , Poisoning/pathology , Rats , Rats, Wistar , Sulfones/poisoning , Time FactorsSubject(s)
Mutagens , Procarbazine/toxicity , Animals , Chromosome Aberrations , Erythrocytes/drug effects , Female , Fetal Blood/drug effects , Male , Mice , RatsSubject(s)
Cell Nucleus/drug effects , Ethylmercuric Chloride/toxicity , Ethylmercury Compounds/toxicity , Lead/toxicity , Organometallic Compounds , Animals , Bone Marrow/drug effects , Bone Marrow/ultrastructure , Cyclophosphamide/toxicity , Dose-Response Relationship, Drug , Erythrocytes/drug effects , Erythrocytes/ultrastructure , Female , Male , Mice , Mutagenicity Tests/methodsABSTRACT
Some results of a study on the clastogenicity of chemicals in vivo are reported. The chromosomes in lymphocytes from whole blood cultures were studied in 60 subjects permanently exposed for about 6 years to several occupational chemicals acting concomitantly, and in 5 controls. The exposed subjects showed an increase in the rate of chromosomal aberrations as compared to controls.
Subject(s)
Chromosome Aberrations , Environmental Exposure , Mutagens/adverse effects , Female , Humans , MaleSubject(s)
Bone Marrow/drug effects , Cyanates/pharmacology , Animals , Chromosomes/drug effects , Mutagenicity Tests , RatsSubject(s)
Bone Marrow/ultrastructure , Chromosome Aberrations , Chromosomes/drug effects , Cytarabine/pharmacology , Animals , Cell Nucleus , Male , Mice , Mutagenicity TestsSubject(s)
Adjuvants, Immunologic/pharmacology , Lymphocytes/cytology , Neoplasms, Experimental/immunology , Nitrogen Mustard Compounds/pharmacology , Plasma Cells/cytology , Animals , Cell Division , Lymphocyte Activation , Neoplasm Transplantation , Rats , Thiamine Pyrophosphate/pharmacology , Thymus Extracts/pharmacology , Transplantation, HomologousSubject(s)
Chromosome Aberrations , Mutagens , Occupational Diseases/chemically induced , Cyanates , Humans , RiskABSTRACT
Among the in vivo cytogenetic tests employed for chemically induced mutagenicity, a recent screening method was selected - the micronucleus test. The micronuclei were investigated, comparatively with chromosome breaks, on the bone marrow of Wistar rats after intraperitoneal administration of different doses of Cyclophosphamide (CY) applied in one or two injections at 24 hrs interval. The good relationship between these two tests was proved in evaluation of cytogenetic risk.
