ABSTRACT
Mycosis fungoides (MF) is the most prevalent subtype of primary cutaneous T-cell lymphomas (CTCLs). Sézary syndrome (SS) is another entity defined by leukaemic involvement, lymphadenopathy and erythroderma. Pegylated liposomal doxorubicin (PEG-DOXO) is an anthracycline used in the management of advanced primary CTCL, particularly in induction strategies. However, there are limited data on its effectiveness and tolerability in real-life patients. We report 36 patients who received PEG-DOXO for MF or SS in our centre, describing the patients' characteristics, response rates and tolerance to the treatment. The best overall responses were observed for the skin, with lower response rates for nodal involvement and moderate responses for blood disease. The treatment was mainly well tolerated, without severe adverse events, and no cardiotoxicity was observed on cardiac function monitoring.
Subject(s)
Lymphoma, T-Cell, Cutaneous , Mycosis Fungoides , Sezary Syndrome , Skin Neoplasms , Doxorubicin/adverse effects , Doxorubicin/analogs & derivatives , Humans , Lymphoma, T-Cell, Cutaneous/pathology , Mycosis Fungoides/drug therapy , Mycosis Fungoides/pathology , Polyethylene Glycols , Sezary Syndrome/drug therapy , Sezary Syndrome/pathology , Skin Neoplasms/pathologySubject(s)
Acne Vulgaris , Hyperostosis , Osteitis , Synovitis , Acne Vulgaris/diagnosis , Acne Vulgaris/drug therapy , Humans , SyndromeABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Exanthema/pathology , Leiomyoma/pathology , Skin Neoplasms/pathology , Biopsy , Skin/pathology , Exanthema/genetics , Leiomyoma/genetics , Skin Neoplasms/geneticsABSTRACT
The first vaccine that shows significant potential in providing broad coverage against serogroup B meningococcal disease has recently been approved. Because of its newness, potential adverse events need to be reported. Here we report a case of urticarial vasculitis, a rare disease in children, in probable relationship with the novel vaccine.
Subject(s)
Meningococcal Infections/prevention & control , Meningococcal Vaccines/adverse effects , Neisseria meningitidis, Serogroup B/immunology , Vasculitis, Leukocytoclastic, Cutaneous/diagnosis , Child , Female , Histamine Antagonists/therapeutic use , Humans , Skin/pathology , Vasculitis, Leukocytoclastic, Cutaneous/etiologyABSTRACT
Tinea imbricata (TI) is a geographically restricted dermatophytosis with distinctive clinical and immunologic features. We present a case of TI occurring in a native Brazilian child with previously undiagnosed human immunodeficiency virus infection. Physicians should bear in mind that diagnosis of TI may be a clinical clue to potentially serious underlying immunodeficiency.
Subject(s)
HIV Infections/diagnosis , Tinea/diagnosis , Trichophyton/isolation & purification , Administration, Oral , Antifungal Agents/therapeutic use , Child, Preschool , Forehead , Griseofulvin/therapeutic use , HIV Infections/drug therapy , HIV Infections/microbiology , Humans , Male , Tinea/drug therapy , Tinea/microbiologyABSTRACT
We report the first case of multisystemic Langerhans cell histiocytes mimicking diffuse neonatal hemangiomatosis clinically. This has been described in patients with congenital self-healing reticulohistiocytosis but not in patients with acute, disseminated, and multisystemic disease. In our experience, dermoscopic findings did not help to diagnose the condition.
Subject(s)
Hemangioma/diagnosis , Histiocytosis, Langerhans-Cell/diagnosis , Skin Neoplasms/diagnosis , Biopsy , Diagnosis, Differential , Epidermis/pathology , Female , Humans , Infant, NewbornABSTRACT
La infección por Papillomavirus humano (VPH) es más frecuente en pacientes inmunodeprimidos, incluyendo la infección por el virus de la inmunodeficiencia humana (VIH), donde se ha estudiado particularmente la infección cervical por cepas genitales oncogénicas de VPH. Hemos estudiado las características de la infección por VPH en una consulta dermatológica de pacientes infectados por el VIH, con una muestra predominante de hombres jóvenes adictos a drogas por vía parenteral (ADVP), con lesiones verrucosas anogenitales. Las 120 tomas de 61 pacientes correspondían a 98 muestras mucosas y 22 no mucosas. La detección en raspados con torunda, principalmente de semimucosas anal y/o genital (también en casos sin lesión), se realizó tras extracción de ADN y amplificación mediante reacción en cadena de la polimerasa (PCR). La tipificación posterior se llevó a cabo mediante digestión por enzimas de restricción e hibridación con sondas específicas. Se detectaron uno o varios tipos de VPH en un 74% de las tomas mucosas de lesiones y en un 31% de las tomas mucosas sin lesión. Los tipos de VPH más encontrados han sido VPH 6 y 11 (33 muestras), frente al VPH 16 (11 muestras) o el VPH 18 (ningún caso). Encontramos tipos de alto riesgo oncogénico asociados a cifras de CD4 inferiores a 150 /mm3. Destacamos, en conclusión, la rentabilidad de la técnica del raspado de mucosas para el clínico como cribaje de infección por VPH, la elevada incidencia de VPH incluso oncogénico en localizaciones sin lesión clínica, la frecuencia de coinfecciones por varios tipos de VPH y el predominio del VPH 6 en nuestro medio (AU)
