[Change in the spectrum of lipids and apoproteins A1 and B as affected by hypothiazide and pratsiol in patients with hypertension]. / Izmenenie spektra lipidov, apoproteinov A1 i B pod vliianiem gipotiazida i pratisola u bol'nykh gipertonicheskoi bolezn'iu.

A comparative study of changes in plasma lipids, apo-A1 and apo-B under the effect of 2-week, 2-month and 6-month treatments with hydrochlorothiazide and pratsiol was conducted in 48 patients with arterial hypertension. Hydrochlorothiazide caused a significant increase in total cholesterol (CH), LDL cholesterol, apo-A1 and apo-B, and a decrease in cholesterol load of HDL particles as compared to placebo effects. Increased levels of HDL cholesterol were only noted in the early days of hydrochlorothiazide treatment. Pratsiol therapy produced a significant reduction of total triglycerides (TG), VLDL cholesterol, the cholesterol atherogenic coefficient, the apo-B/apo-A1 ratio, and increased HDL cholesterol. The activity of post-heparin lipoprotein lipase was not basically affected by hydrochlorothiazide, while pratsiol evoked a significant increase in its activity. The pratsiol-associated TG decrease was more pronounced in patients with elevated TG baseline, and the rise in HDL cholesterol, in those with initial hypo-alphacholesterolemia. Therefore unlike hydrochlorothiazide, pratsiol is associated with a favorable antiatherogenic trend of changes in the lipoprotein spectrum.

[Effect of obzidan and pratsiol therapy on the blood plasma lipid profile and on the high- and low-density lipoprotein apoproteins in hypertension patients]. / Vliianie terapii obzidanom i pratsiolom na lipidnyi profil' plazmy krovi i apoproteiny lipoproteidov vysokoi i nizkoi plotnosti u bol'nykh gipertonicheskoi bolezn'iu.

The effect of an 8-week monotherapy with propranolol and pratsiol on plasma lipid levels and apo-Al and apo-B, apoproteins of high- and low-density lipoproteins (HDLP, LDLP) was studied in 20 patients with second-stage essential hypertension. Propranolol caused no significant changes in plasma lipid spectrum, however it produced a significant rise in apo-Al levels and reduced the cholesterol load index per weight unit of apo-Al in HDLP particles. Pratsiol treatment caused a significant reduction in plasma triglycerides, cholesterol of very-low-density lipoproteins, the cholesterol atherogenic coefficient and the apo-B/apo-Al ratio, and raised the level of HDLP cholesterol. The findings suggest that plasma lipoprotein effects should be taken into account in the choice of hypotensive agents.

[Methodologic approach to individual evaluation of the pharmacodynamic effects of single doses of hydralazine, endralazine, prazosine and propranolol in hypertension patients]. / Metodicheskii podkhod k individual'noi otsenke farmakodinamicheskogo éffekta odnokratnykh doz gidralazina, endralazina, prazozina, propranolola u bol'nykh gipertonicheskoi bolezn'iu.

The possibility to apply impedance cardiography technique and individual statistical analysis based on Dixon's criterion to pharmacodynamic studies of single hydralazine ( apressine ), prazosine ( pratsiol ), endralazine ( mirethilan ), propranolol (obsidan) doses is discussed. 12 patients with essential hypertension, stage II were examined. Blood pressure was measured by the method of Korotkov , heart volume and total peripheral vascular resistance were determined by impedance cardiography. Apressin , mirethilan , pratsiol and obsidan doses were 50-100 mg, 5-15 mg, 2-5 mg and 80-120 mg, respectively. The drug effect was compared with that of placebo. Impedance cardiography in combination with the method of Korotkov were shown to be appropriate for recording qualitative alterations of hemodynamic parameters during pharmacodynamic studies of single apressine , mirethilan , pratsiol an obsidan doses. The data obtained allow objective individual assessment of single dose efficacy based on Dixon's criterion.

[Morphological characteristics of the internal organs of experimental animals after administration of different doses of chanerol]. / Morfologicheskaia kharakteristika vnutrennikh organov eksperimental'nykh zhivotnykh pri primenenii razlichnykh doz khanerola.

Experiments were conducted with rats and dogs to study the influence of different hanerol doses on the condition of anumber of internal organs. The drug was introduced in a single dose: to rats in the form of a 0.1% solution in amounts of 6, 8, 10, 13, 20 and 30 mg/kg and to dogs as a 0.1% solution in doses of 24 mg/kg. Doses of 20 and 30 mg/kg for rats and 24 mg/kg for dogs proved intolerable and animals perished in consequence of circulatory disturbances (blood effusion, thrombosis of capillaries in the lungs, spleen, suprarenals and in organs of the gastro-intestinal tract). On application of doses amounting to 6 and 13 mg/kg in rats and 6-12 in dogs the animals remained alive, although the lungs, testes and the spleen were found to be afflicted with thrombosis of individual capillaries and there was demonstrable the the development of pneumosclerotic foci, atrophy of spermatogenic epithelium and slight splenic infarctions.