ABSTRACT
A unique case of generalized bacillary angiomatosis (BA) in a patient who died of HIV infection is described. Apart from widely spread skin lesions there were also manifestations in the brain, lungs, heart, esophagus and intestine. Gram-negative bacteria were found in the histological sections. Oval and roundish bacteria with a predominantly perivascular location were found electron microscopically in the archives material.
Subject(s)
AIDS-Related Opportunistic Infections/pathology , Angiomatosis, Bacillary/pathology , Aged , Fatal Outcome , Humans , MaleABSTRACT
Asymptomatic syphilis eventually manifesting with symptoms of the secondary disease was observed in a male with HIV-infection. Large focuses of alopecia reported in this male are suggested as a clinical marker of HIV-infection. A defective antibody response to T. pallidum in HIV-infection has been confirmed. Levomycetin (0.5 g 4 times a day in 5-20-day courses at two-week intervals) proved highly effective as compared to penicillin, erythromycin and tetracycline administration due to poor tolerance of the above antibiotics.
Subject(s)
HIV Infections/complications , HIV-1 , Syphilis/diagnosis , Adult , Chloramphenicol/therapeutic use , Drug Therapy, Combination/therapeutic use , Erythromycin/therapeutic use , Histamine H1 Antagonists/therapeutic use , Hospitalization , Humans , Male , Recurrence , Syphilis/drug therapy , Syphilis/pathology , Tetracycline/therapeutic useABSTRACT
The first AIDS patient was a homosexual male who contacted HIV infection in 1982 in Tanzania. In December 1985 the first sign of Kaposi's sarcoma was noted in this patient. HIV infection was diagnosed in him only in February 1987. He was treated with AZT, reaferon, immunoglobulin and underwent electronic therapy. His state of health was stable till February 1991. Then he got severe bacterial pneumonia, candidosis. Pancytopenia progressed. The dose of AZT (0.8 g daily) was increased and intensive antibiotic therapy and the course of diflucan were prescribed. In spite of this treatment the number of CD4 lymphocytes catastrophically decreased (CD4 = 0.01 x 10(9)/l) and the patient died. Thus, more than 63 months passed from the date of the appearance of the first symptoms of AIDS in the patient to his death.
Subject(s)
HIV Infections/diagnosis , HIV-1 , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/therapy , Acquired Immunodeficiency Syndrome/diagnosis , Acquired Immunodeficiency Syndrome/therapy , Adult , Candidiasis, Oral/diagnosis , Candidiasis, Oral/therapy , Combined Modality Therapy , HIV Infections/therapy , Hospitalization , Humans , Leukoplakia, Oral/diagnosis , Leukoplakia, Oral/therapy , Male , Pulmonary Fibrosis/diagnosis , Pulmonary Fibrosis/therapy , Sarcoma, Kaposi/diagnosis , Sarcoma, Kaposi/therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/therapy , Tanzania , Tongue Neoplasms/diagnosis , Tongue Neoplasms/therapy , USSRABSTRACT
Skin and mucosal lesions are described in a 40-year-old man who suffered from HIV infection in the stage of secondary diseases. The diagnosis was supported by demonstration of antibodies to HIV in the immune blotting test. The clinical manifestations were reduced to steady fever, generalized lymphadenopathy, pyoderma vegetans and chancriform pyoderma, candidiasis of the oral cavity, and seborrheic dermatitis, HIV infection was diagnosed 4 years after the appearance of pyoderma which initially was amenable by external antibacterial agents and then became resistant to them. Eruptions of pyoderma vegetans simulating wide condylomas were located in inguinal folds, on the internal surface of the thighs and scrotum; the chancriform focus was located in the internal preputial layer. The treatment with azothymidine combined with antibacterial and antimycotic agents led to the improvement of the patient's general status and to the reduction of local lesions. However, on recommendations of an unknown witch doctor who started treating him with the aid of reflexotherapy, phytotherapy and bioenergetic actions the patient stopped receiving the treatment prescribed and did not report for control examinations. After 5 months he died of brain edema.
