1.
Nucleosides Nucleotides Nucleic Acids
; 20(4-7): 809-13, 2001.
Article
in English
| MEDLINE
| ID: mdl-11563121
ABSTRACT
Modified oligonucleotides bearing spermine groups (ODN-sper) with increased binding affinity to DNA have been synthesized. The ability of these ODN-sper to bind within superhelical double-stranded DNA by strand invasion has been studied. The uptake by a supercoiled plasmid was 3 fold higher for the ODN-sper than for the unmodified oligonucleotides.