ABSTRACT
Maintenance of the bactericidal activity and organoleptic properties of 3% and 5% stabilized aqueous solutions of pectin (Pepidol PEG, 3% and Pepidol PEG, 5%) stored for prolonged periods and at various temperatures was studied. Pepidol PEG was shown to preserve its bactericidal activity and organoleptic properties for 28 months when stored at rather wide ranges of the environmental temperature. The drug did not lose its properties after freezing and subsequent melting. The results of the study allowed to increase the period of Pepidol PEG use up to 18 months and the storage temperature ranges up to -30 degrees to +30 degrees C.
Subject(s)
Antidiarrheals/pharmacology , Pectins/pharmacology , Antidiarrheals/chemistry , Drug Stability , Drug Storage , Humans , Pectins/chemistry , Salmonella enteritidis/drug effects , Salmonella typhimurium/drug effects , Shigella sonnei/drug effects , Taste , Temperature , Time FactorsABSTRACT
The effect of alimentary pectin obtained from different raw materials (apple, tomato, cotton-wool) on the causative agents of infectious diarrheal diseases, belonging to the genera Shigella, Salmonella, Klebsiella, Enterobacter, Proteus and Citrobacter, was studied under experimental conditions and in clinical observations. The study revealed that pectin, irrespective of raw material used for its production, produced an inhibiting effect on these microorganisms. This effect was most pronounced, both under experimental and clinical conditions, when 5% pectin solution was used. A rapid suppress of diarrhea and other manifestations of the infectious syndrome was observed in patients. The patients treated with pectin stayed in the hospital, on the average, 2-3 days less than the control group of patients treated with antibiotics and other chemotherapeutic preparations.
Subject(s)
Bacteria/drug effects , Bacterial Infections/microbiology , Intestinal Diseases/microbiology , Pectins/pharmacology , Acute Disease , Adolescent , Adult , Bacteria/isolation & purification , Bacterial Infections/drug therapy , Dose-Response Relationship, Drug , Drug Evaluation , Female , Humans , Intestinal Diseases/drug therapy , Male , Microbial Sensitivity Tests , Pectins/therapeutic use , Time FactorsABSTRACT
A study was made of a possibility of prognostication of the number of patients (morbidity per 100 000 residents) with hemorrhagic fever with the renal syndrome in conditions of the Primorsk region. The main factors characterizing this disease were analyzed with the use of the "Minsk-22" computer; these were dynamics of the populations of murine rodents, metereological data, morbidity. A method of prognostication of the number of patients (morbidity) with hemorrhagic fever and a renal syndrome in the Primorsk region for the current year was elaborated.
