ABSTRACT
The article is devoted to the analysis of features of natural history of hepatitis C in Donetsk region, with the purpose to determine the number of patients in need of treatment in the first place, forecast on their cure, determination of the number of patients needing the retreatment. Namely, it is showed the age distribution of acute viral hepatitis B and C among the patients of Donetsk region, the percentage of patients with different severity of fibrosis inthe population of patients with chronic hepatitis C in Donetsk region. The stage of liver fibrosis and the degree of disease activity were compared. Furthermore, it is showed the distribution of genotypes of hepatitis C virus in a population of patients of Donetsk region.
Subject(s)
Hepacivirus/genetics , Hepatitis B/epidemiology , Hepatitis C, Chronic/epidemiology , Liver Cirrhosis/epidemiology , Acute Disease , Adolescent , Adult , Aged , Aged, 80 and over , Antiviral Agents/therapeutic use , Child , Child, Preschool , Female , Genotype , Health Services Needs and Demand , Hepacivirus/drug effects , Hepacivirus/isolation & purification , Hepatitis B/complications , Hepatitis B/drug therapy , Hepatitis B/virology , Hepatitis B virus/drug effects , Hepatitis B virus/genetics , Hepatitis B virus/isolation & purification , Hepatitis C, Chronic/complications , Hepatitis C, Chronic/drug therapy , Hepatitis C, Chronic/virology , Humans , Infant , Liver Cirrhosis/drug therapy , Liver Cirrhosis/etiology , Liver Cirrhosis/virology , Male , Middle Aged , Molecular Typing , Prognosis , Severity of Illness Index , Ukraine/epidemiologyABSTRACT
The influence of photochemically activated 40% solution of Levomecol ointment toward the tissue apoptosis while occurrence of ischemic complications of diabetes mellitus was studied in experiment on 184 adult mongrel white male rats weighted 250-310 g. While modelling of ischemic complications of diabetes mellitus there was revealed the cells apoptosis regulation in soft tissues of the affected lower extremities, causing worsening of the reparative processes course. Application of photochemically activated 40% solution of Levomecol ointment had promoted an effective correction of disorders in the cells apoptosis regulation. It substantiates the expediency of the method introduction into clinical practice.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Apoptosis/drug effects , Chloramphenicol/therapeutic use , Diabetes Complications , Ischemia/etiology , Ischemia/therapy , Lower Extremity/blood supply , Muscle, Skeletal/drug effects , Photochemotherapy/methods , Uracil/analogs & derivatives , Animals , Anti-Bacterial Agents/administration & dosage , Chloramphenicol/administration & dosage , Combined Modality Therapy , Disease Models, Animal , Drug Combinations , Ischemia/drug therapy , Ischemia/pathology , Lower Extremity/pathology , Male , Ointments , Rats , Solutions , Uracil/administration & dosage , Uracil/therapeutic useABSTRACT
In 31 patients with purulent wound of soft tissues more rapid cleansing and healing of the wound, the immunity indexes normalization were noted while application of immunomodulator thymogen in combination with the siliceous sorbent sillard application and adaptogenic preparation--tincture of Echinacea Purpurea.
