[Autoantibodies to thyroid antigens levels in the population of the Russian Arctic at different levels of blood dopamine.]

Neuroimmunoendocrine regulation of the thyroid gland involves the use of autoantibodies as regulatory molecules to stimulate or reduce the activity of the tissues of the organ itself. A huge number of regulatory signal molecules and factors, acting directly or indirectly, often plays a much more significant role, both in ensuring normal activity and in pathological processes. In this regard, it was interesting for us to determine the possible effect of dopamine at its various concentrations in the blood on the levels of thyroglobulin and antibodies to thyroid antigens. A survey of 110 men and 206 women aged 22 to 75 years who were born and lived in the Arctic zone of the Russian Federation and had no diseases of the endocrine and immune system was conducted. Dopamine concentrations were determined in blood plasma, thyroid stimulating hormone (TSH), thyroglobulin (TG), antibodies to thyroperoxidase (at-TPO) and thyroglobulin (at-TG) in serum. Higher concentrations of thyrotropin and thyroglobulin and lower concentrations of at-TG and at-TPO were shown with increasing dopamine levels from undetectable values to normative and excess levels. We explain this by the influence of dopamine on a-adrenoreceptors of antibody-producing cells and changes in the secretion of immunoglobulins class G, subclasses of which include at-TG and at-TPO. The appearance of different from zero values of autoantibodies concentrations in themselves, we associate with the negative impact of the conditions of the North and the prenosological state of the organism. Their higher values in women with low levels of dopamine can be explained by the lack of its immunomodulatory activity.

[Levels of sex hormones, sex hormone binding globulin, antisperm antibodies and dopamine in postmanopausal women of nomadic and settled aboriginal and local caucasoid populations of the arctic territories.]

Positive changes in the society led to an improvement in quality and lifetime; as a result the menopause in women lengthens much longer, in light of this the relevance of studying hormonal changes increases, especially among the representatives of different groups living in the Arctic territories. The study was carried out on 138 women who included nomadic and settled aboriginal and local Caucasoid postmenopausal populations, permanently residing in the Arctic territories of Russia. The greatest difference in the studied blood indicators was shown between the local Caucasoid and aboriginal population. A greater imbalance in the content of dopamine in Aborigines compared with the European population was combined with a higher levels of prolactin, sex hormone binding globulin, antisperm antibodies and with lower concentrations of lutropine, progesterone, total and free testosterone. In the settled aboriginal population compared with nomadic one there were shown the larger proportion of people with low levels of dopamine, lutropine, follitropin and high levels of prolactin, sex hormone binding globulin in the presence of increased number of feedbacks in the hypothalamic-pituitary-gonadal system, which suggested more pronounced reduction of its activity. The evident imbalance of the dopamine content in the aboriginal population was combined with the absence of connections between dopamine level and the parameters of the hypothalamic-pituitary-gonadal system. Positive correlation between the contents of dopamine and lutropin in the European population suggested the stimulating effect of dopamine on the hypothalamic-pituitary-gonadal system. Affected by imbalanced dopamine content the decreased activity of gonadotropic pituitary gland function as well as the peripheral part of the hypothalamic-pituitary-gonadal system was registered in the aboriginal Arctic population in comparison with the local European one, which was more pronounced in the settled aboriginals.