ABSTRACT
We describe an unusual case of verruciform xanthoma on the lingual surface of the gum that coexisted with oral discoid lupus erythematosus.
Subject(s)
Lupus Erythematosus, Discoid/complications , Mouth Diseases/pathology , Xanthomatosis/complications , Diagnosis, Differential , Female , Humans , Lupus Erythematosus, Discoid/pathology , Middle Aged , Mouth Mucosa/pathology , Xanthomatosis/pathologyABSTRACT
An unusual case of testicular embryonal carcinoma metastatic to the labial mucosa of the upper lip is reported. The clinical features and the management of the metastatic oral lesion are presented. In patients with known systemic malignancy, oral swellings may be an indication of a metastatic deposit.
Subject(s)
Carcinoma, Embryonal/secondary , Lip Neoplasms/secondary , Testicular Neoplasms/pathology , Adult , Biopsy/methods , Carcinoma, Embryonal/metabolism , Chorionic Gonadotropin/metabolism , Fatal Outcome , Humans , Lip Neoplasms/metabolism , Male , Neoplasm Proteins/metabolism , Tomography, X-Ray Computed/methods , alpha-Fetoproteins/metabolismABSTRACT
Metastases to the jaws and oral soft tissues are rare. A case of breast angiosarcoma metastatic to the mandible and the gingiva, bilaterally in the premolar area is presented. The clinical, histological features and the management of the metastatic oral lesions are reported. Our case emphasises the possibility that in patients with history of breast angiosarcoma, oral inflammatory-like lesions may be an indication of a metastatic deposit.
Subject(s)
Breast Neoplasms/pathology , Gingival Neoplasms/secondary , Hemangiosarcoma/secondary , Mandibular Neoplasms/secondary , Female , Humans , Middle AgedABSTRACT
OBJECTIVE: The purpose of the present study was to investigate the presence of insulin-like growth factor-I (IGF-I) in the labial salivary glands of patients with Sjögren's syndrome and healthy controls and to determine if there are any differences between these two groups. DESIGN: An immunohistochemical study. SUBJECTS AND METHODS: Twenty-five patients with Sjögren's syndrome, 20 healthy controls and 20 patients with mucoceles of the lip were used in this study. All individuals underwent a systemic evaluation and a lip biopsy. Sections from the lip biopsies were stained with haematoxylin and eosin (H&E). Immunohistochemical staining was also performed using a three-step indirect immunoperoxidase for IGF-I. RESULTS: The light microscopic examination revealed the presence of a mononuclear infiltration in the labial salivary glands of patients with Sjögren's syndrome. Most of the infiltrates were lymphocytes. Immunohistochemically an intense staining result was apparent in the same group. In contrast sections of labial salivary glands of healthy individuals and of patients with mucoceles revealed very weak staining. CONCLUSIONS: The above findings and the fact that both lymphocytic infiltration and IGF-I were predominantly seen in ductal regions, suggest that IGF-I may be a target of autoimmunity in Sjögren's syndrome.
Subject(s)
Insulin-Like Growth Factor I/analysis , Lip/metabolism , Salivary Glands, Minor/metabolism , Sjogren's Syndrome/metabolism , Adult , Aged , Autoimmune Diseases/metabolism , Autoimmune Diseases/pathology , Biopsy , Coloring Agents , Eosine Yellowish-(YS) , Female , Fluorescent Dyes , Hematoxylin , Humans , Immunoenzyme Techniques , Immunohistochemistry , Lip/pathology , Lip Diseases/metabolism , Lip Diseases/pathology , Lymphocytes/pathology , Middle Aged , Mucocele/metabolism , Mucocele/pathology , Salivary Ducts/metabolism , Salivary Ducts/pathology , Salivary Glands, Minor/pathology , Sjogren's Syndrome/pathologyABSTRACT
OBJECTIVE: The aim of this study was to establish a possible association between the degree of differentiation of squamous cell carcinomas (SCC) derived from rat oral tissues treated in vivo with carcinogen 4NQO, and the expression of TGF-beta on epithelial cells and the distribution of extracellular matrix proteins (laminin-collagen type IV). MATERIALS AND METHODS: A parent tumor showing a spectrum of differentiation was used to establish clonal subpopulations that formed differentiated SCC and undifferentiated (spindle cell phenotype) tumours following transplantation to athymic mice. RESULTS: Immunohistological findings revealed the absence of TGF-beta staining on epithelial cells and extracellular matrix proteins in spindle cell tumours. In contrast, staining of SCC revealed a significant number of TGF-beta positive cells and the presence of extracellular matrix proteins. CONCLUSIONS: The findings suggested that there is a positive correlation between histological differentiation, TGF-beta expression and the elaboration of extracellular matrix proteins.
Subject(s)
Carcinoma, Squamous Cell/metabolism , Extracellular Matrix Proteins/biosynthesis , Transforming Growth Factor beta/metabolism , Animals , Cell Differentiation/physiology , Collagen/biosynthesis , Epithelium/metabolism , Humans , Immunohistochemistry , Laminin/biosynthesis , Male , Mice , Mice, Nude , Mouth Mucosa/metabolism , Mouth Mucosa/pathology , Rats , Rats, Sprague-Dawley , Tumor Cells, CulturedABSTRACT
This study examined the cytogenetic characteristics of keratinocyte cell lines derived from rat oral tissues treated in vivo with the carcinogen 4-nitroquinoline-N-oxide. A parent tumour with a spectrum of differentiation was used to establish clonal subpopulations that formed differentiated (squamous cell carcinomas; SCCs) and undifferentiated (spindle cell phenotype) tumours following transplantation to athymic mice. By contrast to spindle cell tumours, SCCs elaborated basement membrane proteins (laminin and collagen IV). Both diploid and tetraploid subpopulations formed either SCCs or spindle cell tumours. An unbalanced 10q+ translocation was common to all cell lines. Anomalies of chromosomes 3 and 12 (gain, loss, deletions, translocations) were present only in cell lines that formed spindle cell tumours and were absent in keratinocytes forming SCCs. The results suggest that proto-oncogenes and/or tumour suppression genes located to rat chromosomes 3 and 12 may control tumour cell differentiation.
