ABSTRACT
In a previous study, we demonstrated wide variability in the access to oestrogen receptor (ER) measurement, patient selection, choice of technique and the cut-off point for positivity. The aim of this study was to update information on the current use of ER and progesterone receptor (PR) measurement in the United Kingdom (UK). Questionnaires, asking about availability, use and technique of ER and PR measurement, were returned from 170 (74%) units in the UK. Where ER positivity was determined using the percentage of cells staining positive (33%), the absolute cut-off point for positivity varied widely from 5 to 80% of cells. Of the 170 responding units, 107 (63%) felt that PR measurement was important. This study confirms considerable variability in both the technique of ER measurement and the absolute cut-off point for positivity (5-80%). It is essential that a consensus be reached regarding the choice of technique, as well as the threshold for positivity.
Subject(s)
Breast Neoplasms/chemistry , Neoplasm Proteins/analysis , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Attitude of Health Personnel , Decision Making , Female , Humans , Immunohistochemistry/methods , Practice Patterns, Physicians' , Surveys and QuestionnairesABSTRACT
A rare case of the solid variant of pure intracystic papillary carcinoma (IPC) in a 72-year-old male is described with a review of the literature. Currently, there is no clear consensus as to how this condition is best managed. Literature review demonstrates that this is an excellent prognosis tumour. Careful pathological examination should exclude the presence of coexistent conventional ductal carcinoma in situ (DCIS) or invasive carcinoma. In the male, simple mastectomy should be the treatment of choice for pure IPC. Local recurrence is rare.