1.
Chem Commun (Camb)
; 50(100): 15963-6, 2014 Dec 28.
Article
in English
| MEDLINE
| ID: mdl-25384109
ABSTRACT
The Ag(I)-promoted coupling of amino acids and peptides with amino ester thioamides generates peptide imides without epimerisation. The peptide imides undergo regioselective hydrolysis under mild conditions to generate native peptides. This method was employed to prepare the pentapeptide thymopentin in the NâC direction, in high yield and purity.