[Comparative testing of live measles vaccines manufactured in France, Japan, and Russia]. / Sravnitel'nye ispytaniia zhivykh korevykh vaktsin proizvodstva Frantsii, Iaponii i Rossii.

Live measles vaccines prepared from different strains in France, Japan, and Russia were compared at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. Clinical reactions to the tested vaccines were studied in 181 children seronegative before vaccination. Vaccinal reactions to French, Japanese, and Russian were observed in 24.2, 26.5, and 5.9% vaccinees, respectively. The French and Russian vaccines virtually did not differ by the level of seroconversion (96 and 98.1%, respectively). For the Japanese vaccine the level of sero-conversion was lower: 91.6%. The mean titers of antibodies in vaccinees immunized with the French, Japanese, and Russian vaccines were, respectively, 7.36 +/- 0.91, 2.07 +/- 0.42, and 4.40 +/- 0.42 IU.

[Evaluation of the reactivity and antigenic activity of the live measles vaccine, Leningrad-16, in different regions]. / Otsenka reaktogennosti i anigennoi aktivnosti zhivoi korevoi vaktsiny Leningrad-16 v razlichnykh regionakh.

The reactogenicity and antigenic activity of live measles vaccine prepared from strain Leningrad-16 were assessed for 4 territories, two of which were exposed to radiation contamination as a result of the Chernobyl accident. The study was carried out at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. The vaccine was weakly reactogenic in all the regions; no grave or uncommon reactions to its administration were observed. Serologic studies revealed a high antigenic activity of the vaccine. The level of seroconversion was estimated as 98.5%. The study failed to detect any appreciable effect of radiation contamination on the tolerance to vaccine or level of immune response.