ABSTRACT
One hundred and sixty seven children on 0-200 microgram/day of inhaled steroid with asthma symptoms and sub-optimal peak flow values (less than 90% of that predicted for their height) were randomly allocated either 400 microgram once daily (nocte with placebo o.m.) or 200 mircrogram twice daily of budesonide Turbohaler for 8 weeks. Bronchdilator usage and symptoms were reduced in both groups at 4 and 8 weeks compared with baseline. There was a significant increase within both groups in morning and evening PEF after 4 and 8 weeks. The increase in evening PEF after 8 weeks was greater in the once-daily group than in the twice-daily group but there were no other significant differences between the groups (morning: +24.6 l/min vs 15.2 l/min, p = 0.059; evening: + 19.7 l/min vs +8.31 l/min; p = 0.013). Budesonide Turbohaler 400 microgram once daily is therefore as effective as 200 microgram twice daily in achieving asthma control in children.
Subject(s)
Anti-Asthmatic Agents/administration & dosage , Asthma/drug therapy , Budesonide/administration & dosage , Child , Child, Preschool , Double-Blind Method , Female , Forced Expiratory Volume , Humans , Male , Peak Expiratory Flow Rate , Treatment Outcome , Vital CapacitySubject(s)
Rhinitis, Allergic, Perennial/diagnosis , Rhinitis, Allergic, Seasonal/diagnosis , Allergens , Anti-Allergic Agents/therapeutic use , Antigens , Desensitization, Immunologic , Environmental Health , Humans , Intradermal Tests , Medical History Taking , Physical Examination , Rhinitis, Allergic, Perennial/therapy , Rhinitis, Allergic, Seasonal/therapy , Skin TestsABSTRACT
Fibrous dysplasia of bones comprising the paranasal sinuses is well recognized. Depending on the anatomic areas of the skull involved by this neoplasm, a combined approach for surgical removal may be necessitated. A case of a patient with fibrous dysplasia of the ethmoid sinus, possibly the first reported case of such change in the ethmoid bone itself, is presented. A two-stage, combined otolaryngologicneurosurgical craniofacial resection was the method of treatment.
Subject(s)
Ethmoid Sinus , Fibrous Dysplasia of Bone/diagnosis , Adult , Diagnosis, Differential , Ethmoid Sinus/diagnostic imaging , Ethmoid Sinus/pathology , Female , Fibrous Dysplasia of Bone/diagnostic imaging , Fibrous Dysplasia of Bone/pathology , Humans , Paranasal Sinus Diseases/diagnosis , Paranasal Sinus Diseases/diagnostic imaging , Paranasal Sinus Diseases/pathology , RadiographyABSTRACT
There are many pathologic processes that occur in the mouth which have various intraoral manifestations. The differential diagnosis of pigmented lesions of the oral cavity takes on a high degree of significance because therapy may span such a wide range from no treatment at all to massive radical resection for melanoma. A thorough understanding of pigmented lesions of the oral cavity would assist the clinician in establishing a diagnosis and subsequent treatment plan. A comprehensive review of the literature and a discussion of oral pigmented lesions including infiltrative malignant melanoma is presented.