BRIGHTEN Heart: Design and baseline characteristics of a randomized controlled trial for minority older adults with depression and cardiometabolic syndrome.

OBJECTIVES: African American and Hispanic elderly are at elevated risk of both depression and cardiovascular disease, relative to non-Hispanic whites. Effective interventions are therefore needed to address depressive symptoms and to reduce these disparities. BRIGHTEN Heart was a behavioral randomized controlled trial to test the efficacy of a virtual team intervention in reducing depressive symptoms in minority elderly as measured by the 9-item Patient Health Questionnaire (PHQ9). STUDY DESIGN: 250 African American and Hispanic adults, age ≥60 years, with comorbid depression and overweight/obesity were randomized. Participants randomized to the Intervention condition received a social work evaluation, team-based electronic consultation, case management, and psychotherapy over a 12 month period. Control participants were enrolled in a membership program that provided health classes and other services to support chronic disease self-management. Blinded research assistants completed assessments at baseline, and 6 and 12 months postrandomization. RESULTS: The study population was characterized by low socioeconomic status, with 81.4% having a household income of less than $20,000. Although median depression scores were in the mild range, 25% of participants had scores showing moderate to severe depression at baseline. 75% of participants had four or more chronic conditions. Significant demographic and clinical differences were observed between the African American and Hispanic populations. CONCLUSIONS: BRIGHTEN Heart was designed to rigorously test the efficacy of a multi-level intervention to reduce comorbid depressive symptoms and cardiovascular risk in minority elderly. Investigators successfully recruited a cohort well suited to testing the study hypothesis.

Moderate Wine Consumption Inhibits the Development of the Metabolic Syndrome: The Study of Women's Health Across the Nation (SWAN).

We investigated the relationship between wine consumption and the metabolic syndrome (MetS) in a longitudinal, eight-year study of the natural history of the menopause transition at seven geographical sites in the United States. Although similar in age, the 527 African American women had a worse metabolic profile than 1057 Caucasian women. Moderate wine consumption (one glass/day) was less common among African American women but was associated with a better lipid profile in both ethnic groups. Compared to women who drank one glass of wine per day, those who consumed no wine had twice the risk of developing the MetS.

A population-based longitudinal study of cognitive functioning in the menopausal transition.

BACKGROUND: No longitudinal studies have tracked cognitive performance through the menopausal transition and thus the impact of the transition on cognition, independent of aging, is not known. The authors hypothesized that a decline in cognitive functioning occurs as women progress through the menopausal transition, independent of age, educational level, family income, ethnicity, and baseline self-perceived health. METHOD: The authors began a population-based, longitudinal study in January 1996 with yearly follow-up interviews. This report includes follow-up through November 2001. The authors randomly selected African American and white women from a census of two contiguous Chicago communities. After screening for eligibility (age 42 to 52 years, premenopausal or early perimenopausal, no exogenous hormone use in the past 3 months, and no hysterectomy), 868 agreed to participate. Women who became pregnant, had a hysterectomy, or began using hormones were censored from that time onward. This study reports on 803 women for whom cognitive assessments were available. The authors assessed working memory (Digit Span Backward) and perceptual speed (Symbol Digit Modalities Test). RESULTS: Contrary to the hypothesis, the authors found small but significant increases over time during the premenopausal and perimenopausal phases. This trend was not accounted for by chronological age, education, family income, ethnicity, or baseline self-perceived health. CONCLUSIONS: Transition through menopause is not accompanied by a decline in working memory and perceptual speed.

Body mass index in mid-life women: relative influence of menopause, hormone use, and ethnicity.

OBJECTIVE: To assess the relative influence of menopausal status and hormone use on body mass index (BMI) among a multiethnic sample of mid-life women. DESIGN: Cross-sectional telephone survey conducted at seven sites where each site targeted an ethnic minority group and Caucasians as part of Study of Women's Health Across the Nation (SWAN). SUBJECTS: A total of 7181 Caucasians, 3949 African-Americans, 1660 Hispanics, 562 Chinese Americans, and 803 Japanese Americans between ages of 40 and 55 y residing in or near Boston, Chicago, Detroit, Los Angeles, Newark, NJ, Oakland, CA, and Pittsburgh, PA. MEASUREMENTS: Self-reported BMI based on weight in kg divided by height in m(2) menopausal status, physical inactivity, postmenopausal hormone use, ethnicity, and age in years. RESULTS: Compared to premenopausal women (covariate adjusted M=27.3), women reporting a surgical menopause (M=28.2) or being in the perimenopausal transition (M=27.7 for early and 27.9 for late perimenopause) had higher BMI. Women reporting a natural menopause (M=27.4) did not have a higher BMI than premenopausal women, after adjusting for chronological age and other covariates. Hormone use was associated with lower BMI (M=26.5 vs 27.3). A comparison of effect sizes showed that menopausal status (F=13.1), followed by chronological age (F=24.0), were the least powerful predictors of BMI, whereas the more powerful predictors were physical activity level (F=1377.1) and ethnicity (F=400.5). CONCLUSIONS: The menopausal transition affects body mass index in mid-life, but the effect is small relative to other influences. Interventions to increase physical activity are highly recommended to prevent increases in adiposity common in mid-life.

Medical illness, past depression, and present depression: a predictive triad for in-hospital mortality.

OBJECTIVE: The authors' objectives were to determine 1) whether major depressive disorder diagnosed according to DSM-IV criteria modified for the medically ill predicted in-hospital mortality better than major depressive disorder diagnosed according to inclusive DSM-IV criteria and 2) whether a history of depression and current depression predicted mortality independent of severity of physical illness. METHOD: Of 392 consecutive medical inpatients, 241 were interviewed within the first 3 days of admission and 151 were excluded from the study. Chart review and a clinical interview that included the Schedule for Affective Disorders and Schizophrenia were used to determine demographic variables, past psychiatric history, psychiatric diagnoses, and illness measures. Diagnoses included major depressive disorder and minor depression diagnosed according to DSM-IV criteria that included all symptoms regardless of etiology and according to criteria modified for the medically ill (hopelessness, depression, or anhedonia were used as the qualifying affective symptoms; depressive symptoms were eliminated if easily explained by medical illness, treatments, or hospitalization). The Charlson combined age-comorbidity index was used to measure severity of illness. RESULTS: A diagnosis of major depressive disorder based on criteria modified for patients with medical illness better predicted mortality than a diagnosis based on inclusive criteria. A past history of depression and the Charlson combined age-comorbidity index predicted in-hospital mortality, but demographic variables, pain, discomfort, length of stay, medical diagnoses, and minor depression did not. In the final multivariate logistic regression model, the Charlson combined age-comorbidity index, a modified diagnosis of major depressive disorder, and a history of depression were independent predictors of in-hospital death. CONCLUSIONS: Severity of medical illness, a diagnosis of major depressive disorder based on modified criteria, and a past history of depression independently predicted in-hospital mortality in medical inpatients.

Association between depressive symptoms and mortality in medical inpatients.

The authors interviewed a consecutive series of medical inpatients (N = 241) using the Schedule for Affective Disorders and Schizophrenia to determine which depressive symptoms are associated with in-hospital mortality. Fifteen depressive symptoms, pain, and physical discomfort were assessed along with medical comorbidity. Twenty patients died in-hospital (8.3%). Logistic regression showed that anhedonia, hopelessness, worthlessness, indecisiveness, and insomnia predicted in-hospital death after adjusting for physical comorbidity and age. Clinicians should be aware that these depressive symptoms may predict mortality in medical inpatients. Future studies should address which treatment modalities lead to better outcomes.

The impact of emotions on cardiovascular health.

Recent research suggests that the maintenance of emotional well-being is critical to cardiovascular health. People who feel lonely, depressed, and isolated have been found to be significantly more likely to suffer illnesses and to die prematurely of cardiovascular diseases than those who have adequate social support. Consequently, the development of appropriate interventions to improve the emotional health of people with certain psychosocial risk factors has become an important research goal. It is anticipated that such interventions will increase the life expectancy of people at risk and that it may also save millions of dollars in medical care costs. First, however, researchers in this field must identify specific emotional risk factors and must agree upon a working definition of "good emotional health." Such explicit definitions, as well as additional data, are essential to educating physicians and insurers so that consideration of emotional health can be integrated into basic medical care.

Diagonal earlobe creases and prognosis in patients with suspected coronary artery disease.

PURPOSE: To determine whether high-risk patients with unilateral, bilateral, or no earlobe creases (ELC) have different prognoses for common sequelae of coronary heart disease. PATIENTS AND METHODS: Two hundred sixty-four consecutive patients from a university-based coronary care unit or catheterization laboratory were blindly followed up for 10 years, using questionnaires, medical records, and death certificates. The primary outcome measure was time to cardiac event; namely, coronary artery bypass graft (CABG), myocardial infarction (MI), or cardiac death. Analyses included log-rank tests and Cox proportional hazards regression modelling. RESULTS: The number of creased ears was significantly associated, in a graded fashion, with 10-year cardiac event free survival: 43.5% +/- 5.7%, 33.0% +/- 6.7%, or 17.5% +/- 4.6% (mean +/- standard error for 0, 1 or 2 ELC, respectively; P = 0.003). After adjustment for 10 known cardiac risk factors, including age and left ventricular ejection fraction, the relative risk for a cardiac event for a unilateral ELC, relative to 0 ELC, was 1.33 (95% confidence interval [CI] 1.10 to 1.61, P = 0.02), and for bilateral ELC, it was 1.77 (95% CI 1.21 to 2.59, P = 0.003). CONCLUSIONS: Ear lobe creases are associated, in a graded fashion, with higher rates of cardiac events in patients admitted to hospital with suspected coronary disease. In such patients, ELC may help to identify those at higher risk for sequelae for coronary disease.

A new system for classification of cardiac death as arrhythmic, ischemic, or due to myocardial pump failure.

Existing classifications of cardiac death fail to incorporate current understanding of the pathophysiology of sudden cardiac death. We developed a new scheme for classifying cardiac death that defines 3 categories of underlying mechanism: primary arrhythmia, acute myocardial ischemia/infarction, and myocardial pump failure. Using this new system, we classified the mechanism of 106 definite cardiac deaths from the Recurrent Coronary Prevention Project. Fifty deaths (47%) were classified as arrhythmic, 46 (43%) as ischemic, and 9 (8%) as due to myocardial pump failure (1 death was not classifiable). All 36 witnessed arrhythmic deaths were sudden and 8 of 9 witnessed myocardial pump failure deaths were nonsudden. The 38 witnessed ischemic deaths were split evenly between sudden and nonsudden. Interrater agreement for the classification of mechanism was 100%. This classification scheme, if validated in subsequent studies, will provide a useful algorithm for classifying deaths by underlying mechanism.

Psychosocial predictors of mortality in 83 women with premature acute myocardial infarction.

This was an exploratory investigation of psychosocial risk factors for mortality in women with premature acute myocardial infarction (AMI). Subjects were 83 female participants in the Recurrent Coronary Prevention Project, who were between the ages of 30 and 63 in 1978, nonsmoking, nondiabetic, and at least 6 months beyond their index AMI. Follow-up ranged from 8 to 10 years, with an average of 8.5 years. Six deaths occurred in the 83 women over the follow-up. Univariate predictors of these deaths were arrhythmias on ECG (RR = 7.83, p = .003), being divorced (RR = 6.9, p = .003), being employed without a college degree (RR = 6.8, p = .03), and the inverse of Type A behavior, time urgency, and emotional arousability (p = .03; .005; .006, respectively). Multivariate stepwise logistic regression analysis produced a solution that included as independent predictors: arrhythmias on ECG (RR = 4.01, p = .004), being divorced (RR = 3.43, p = .01), and the inverse of time urgency (RR = 0.35, p = .02). In the multivariate model, "divorced" was interchangeable with "employed without a college degree" and "time urgency" was interchangeable with "emotional arousability." This small sample precludes firm conclusions, but provides a basis for hypothesis development.

Type A behavior pattern: new perspectives on theory, assessment, and intervention.

Research on the Type A behavior pattern (TA) has been plagued by inadequate theory, insensitive assessment, and insufficient interventions. These problems (e.g., using global dichotomous ratings of TA) have contributed to several failures of TA to predict cardiovascular outcomes prompting concern for new approaches. Conceptual models are discussed, such as a transactional model of TA, social cognitive theories (e.g., self-evaluative processes), and associative network theory (e.g., how emotions distort information). The view of hostility as the only pathogenic feature of TA is questioned. The ethnographic gap in TA research is described, and detailed descriptive and experimental case studies are recommended. Profile measures that assess all dimensions of TA are urged along with contextually sensitive multimodal assessments. Unlike results of some correlational studies, controlled TA interventions, although few, have consistently yielded positive results. Study of TA within an expanded conceptual perspective is encouraged, especially controlled experiments and interventions.

Change in coronary-prone behaviors in the recurrent coronary prevention project.

The Recurrent Coronary Preventive Project (RCPP) demonstrated that the addition of Type A counseling to standard cardiac counseling resulted in significant reductions in Type A behavior and in a 44% reduction in reinfarction in post-myocardial infarction patients. The purpose of the present study was to describe the specific behavioural and psychosocial changes that occurred during this Type A treatment. Patients undergoing Type A counseling showed significant reductions not only in Type A behavior, but also in the Type A components of hostility, time urgency, and impatience, when compared with patients in the cardiac control group. They also showed significant decreases in depression and anger, and gains in self-efficacy, and marginally significant gains in social support and well-being. Type A counseling resulted in a dose-response relationship with most psychosocial outcomes, such that an increasing amount of treatment contacts was associated with increasing change. These data are important in that they specify a range of psychosocial factors that were influenced by treatment. These factors can be considered to be among the possible explanations for the efficacy of the RCPP treatment on the reduction of cardiac recurrences.

Effects of type A behavioral counseling and severity of prior acute myocardial infarction on survival.

The hypothesis under investigation was that the beneficial effect of type A behavioral counseling on survival after acute myocardial infarction (AMI) was conditional on the functioning of the cardiovascular system, as determined by the severity of the prior AMI. Subjects were 862 nonsmoking coronary patients in the San Francisco Bay Area, randomized in 1978 to receive, over 4.5 years, cardiac counseling or cardiac counseling plus type A behavioral counseling. Sixteen baseline factors plus an interaction term (severity of AMI X behavioral counseling) were evaluated for their prognostic significance. Behavioral counseling was not a significant predictor of coronary death in the total cohort, but the interaction between counseling and severity of the prior AMI was (p less than 0.05). Thus, the total cohort was divided into 2 subgroups of mild or serious prior AMI, and independent predictors of survival were isolated within each subgroup. In the subgroup with mild prior AMI, independent predictors were anterior AMI (p = 0.02), plasma cholesterol (p = 0.02) and behavioral counseling (p = 0.05). In the subgroup with serious prior AMI, none of the factors evaluated made a significant independent contribution. These findings suggest that a reduction in type A behavior may exert the greatest protection against coronary death in that subgroup of patients for whom the biologic aspects of coronary artery disease are not advanced. They also demonstrate the importance of considering the level of cardiac functioning before determining predictors of survival or optimum postcoronary care.

Psychosocial and physiological predictors of sudden cardiac death after healing of acute myocardial infarction.

Several major prospective studies that have examined the relation between type A behavior and cardiac mortality have failed to find an association. Since psychosocial factors have been implicated in the etiology of sudden cardiac death, it is possible that this association may emerge if sudden cardiac death is distinguished as an outcome distinct from other cardiac mortality. Predictors of sudden death and other cardiac outcomes were examined using data from the Recurrent Coronary Prevention Project, a 4.5-year prospective clinical trial of 1,012 postinfarction patients begun in San Francisco in 1978. A unique set of risk factors was found for the differing outcomes: sudden cardiac death had predominantly psychosocial predictors while nonsudden cardiac death and nonfatal recurrences were predominantly predicted by biologic factors. Type A behavior was an independent predictor of sudden, but not nonsudden, cardiac death in this population (p = 0.04). These results are the first demonstration of a direct relation between stress and sudden cardiac death in a large prospective clinical study, and provide insight into the failure of past prospective studies to find an association between type A behavior and cardiac mortality.

Effect of discontinuance of type A behavioral counseling on type A behavior and cardiac recurrence rate of post myocardial infarction patients.

Three hundred post infarction participants who had received type A behavioral counseling in the Recurrent Coronary Prevention Project, (RCPP) agreed to be followed for 1 additional year after stopping 4.5 years of continuous type A behavioral counseling. One hundred fourteen participants who had served for 4.5 years as controls in the RCPP Study, thus receiving no type A behavioral counseling, volunteered to receive such counseling for 1 year. Eleven of the 300 previously type A counseled RCPP participants were lost to follow-up at the end of the additional year. The remaining 289 subjects at risk were found to have maintained their previously reduced intensity of type A behavior. Their previously observed relatively low cardiac recurrence rate during the additional year also did not significantly change. Ten of the 114 previous control RCPP participants were lost to follow-up at the end of the additional year. The remaining 104 subjects who had received a year's type A behavioral counseling showed a significantly reduced intensity of type A behavior and a similar significant decrease in both the cardiac mortality and morbidity rate. These results suggest that the decline in the intensity of type A behavior and also in the cardiac recurrence rate previously observed in post infarction subjects exposed to type A behavioral counseling persists for at least 1 year after cessation of such counseling.