1.
Mol Cell Biol
; 8(2): 515-21, 1988 Feb.
Article
in English
| MEDLINE
| ID: mdl-2832724
ABSTRACT
We have found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication.