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2.
Cell Tissue Bank ; 6(1): 13-23, 2005.
Article in English | MEDLINE | ID: mdl-15735897

ABSTRACT

A correlation between extractable bone morphogenetic proteins (BMPs) in demineralized bone matrix (DBM) and osteoinduction has been suggested. Extractable BMP-4 and osteoinductivity of DBM from 40 donors were assessed using enzyme-linked immunosorbent assay (ELISA) and in vivo athymic mouse assay, respectively. Extractable BMP-4 level averaged 3.7 +/- 0.21 ng/g of DBM and correlated with osteoinductivity of the DBM in an in vivo assessment of induced newbone formation.


Subject(s)
Bone Morphogenetic Proteins/isolation & purification , Osteogenesis/physiology , Animals , Biological Assay , Bone Demineralization Technique , Bone Matrix/chemistry , Bone Morphogenetic Protein 4 , Bone Morphogenetic Proteins/physiology , Bone Transplantation , Calcium/analysis , Enzyme-Linked Immunosorbent Assay , Humans , Mice , Mice, Nude , Particle Size , Transplantation, Heterologous
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