ABSTRACT
CASE REPORT: A 78-year-old man was referred for evaluation of a limbic lesion in his left eye. This had a gelatinous appearance and an extension of 240 degrees . The lesion was clinically diagnosed to be a conjunctival and corneal intraepithelial neoplasia (CIN). Topical treatment with interferon alpha2b (INFalpha2b) four times daily was started and continued until the lesion had completely resolved at 4 months. DISCUSSION: Topical INFalpha2b alone may be a safe and effective treatment of CIN instead of the other classic alternatives such as surgical excision with cryotherapy, which could induce the development of severe limbic deficiency in cases with extensive disease.
Subject(s)
Antineoplastic Agents/administration & dosage , Carcinoma in Situ/drug therapy , Conjunctival Neoplasms/drug therapy , Corneal Diseases/drug therapy , Interferon-alpha/administration & dosage , Administration, Topical , Aged , Humans , Interferon alpha-2 , Male , Recombinant Proteins , Treatment OutcomeABSTRACT
Caso clínico: Varón de 78 años remitido por una lesión límbica en ojo izquierdo (OI) de aspecto gelatinoso con una extensión de 240º, que fue diagnosticada clínicamente como una probable neoplasia intraepitelial conjuntivo-corneal (CIN). Se inició tratamiento tópico con interferon alfa2b (INFalfa2b) 4 veces al día hasta conseguir su desaparición completa a los 4 meses de tratamiento.Discusión: El uso aislado del INFalfa2b tópico podría ser una alternativa eficaz y segura en el tratamiento del CIN, frente a otras opciones terapéuticas clásicas como la escisión quirúrgica asociada a crioterapia que podrían condicionar el desarrollo de insuficiencias límbicas severas en casos extensos
Case report: A 78-year-old man was referred for evaluation of a limbic lesion in his left eye. This had a gelatinous appearance and an extension of 240º. The lesion was clinically diagnosed to be a conjunctival and corneal intraepithelial neoplasia (CIN). Topical treatment with interferon alpha2b (INFalpha2b) four times daily was started and continued until the lesion had completely resolved at 4 months. Discussion: Topical INFalpha2b alone may be a safe and effective treatment of CIN instead of the other classic alternatives such as surgical excision with cryotherapy, which could induce the development of severe limbic deficiency in cases with extensive disease
Subject(s)
Male , Aged , Humans , Antineoplastic Agents/administration & dosage , Carcinoma in Situ/drug therapy , Corneal Diseases/drug therapy , Interferon-alpha/administration & dosage , Conjunctival Neoplasms/drug therapy , Administration, Topical , Treatment OutcomeABSTRACT
PURPOSE/METHOD: To report a clinical case of a 21-year old male with a severe corneal abscess due to Pseudomonas aeruginosa refractory to intensive treatment with topical Ciprofloxacin. RESULTS/CONCLUSIONS: A corneal scrapping performed after a wash-out period showed Pseudomonas aeruginosa specimens, which were not sensitive to any of the fluoroquinolones tested. A fortified topical treatment with Ceftazidime healed the corneal abscess. Nowadays, the possibility of resistance to fluoroquinolones should be kept in mind, and we recommend treatment guided by the results of a microbiological study in severe and sight-threatening cases.
Subject(s)
Abscess/microbiology , Anti-Bacterial Agents/therapeutic use , Anti-Infective Agents/pharmacology , Ceftazidime/therapeutic use , Ciprofloxacin/pharmacology , Corneal Ulcer/microbiology , Eye Infections, Bacterial/microbiology , Pseudomonas Infections/microbiology , Pseudomonas aeruginosa/drug effects , Abscess/drug therapy , Adult , Anti-Bacterial Agents/pharmacology , Anti-Infective Agents/therapeutic use , Ceftazidime/pharmacology , Ciprofloxacin/therapeutic use , Contact Lenses, Hydrophilic , Corneal Ulcer/drug therapy , Drug Resistance, Microbial , Eye Infections, Bacterial/drug therapy , Humans , Male , Microbial Sensitivity Tests , Pseudomonas Infections/drug therapyABSTRACT
Objetivo/método: Presentar un caso clínico de un varón de 21 años con un absceso corneal severo causado por Pseudomonas aeruginosa refractario al tratamiento tópico intensivo con ciprofloxacino. Resultados/Conclusiones: Tras un período de lavado, se realizó un raspado corneal cuyo estudio microbiológico reveló la presencia de Pseudomonas aeruginosa resistente a todas las fluoroquinolonas testadas. El tratamiento tópico fortificado con Ceftazidima resolvió el absceso corneal. Consideramos que, en el momento actual, debe tenerse en cuenta la posibilidad de una resistencia a las quinolonas y recomendamos el tratamiento guiado por los resultados del estudio microbiológico en casos severos y con riesgo virtual (AU)
