ABSTRACT
OBJECTIVE: This study aimed to investigate local and systemic effects of 2 concentrations of hyaluronic acid (HA) in rats. STUDY DESIGN: Fifty-four female Wistar rats were allocated to 3 treatment groups (25 mg/mL HA, 5.5 mg/mL HA, and 0.9% NaCl) and 3 subgroups of experimental time (7, 60, and 90 days). The rats were evaluated clinically and then killed. The tongue and right kidney were removed and stained by hematoxylin and eosin and picrosirius (tongue only). RESULTS: The clinical changes did not differ significantly between groups (Kruskal-Wallis: P > .05). Histologically there was significantly greater inflammatory response in the groups with HA compared with control (Kruskal-Wallis: P < .001). All kidney samples were normal. The 25 mg/mL HA group had higher collagen formation (analysis of variance mixed models: P = .016). CONCLUSIONS: HA causes moderate inflammatory reaction to 7 days and mild to 60 and 90 days, which is compatible with tissue repair, and a slightly increased collagen formation around the material was detected.
Subject(s)
Biocompatible Materials/pharmacology , Hyaluronic Acid/pharmacology , Tongue/drug effects , Viscoelastic Substances/pharmacology , Abscess/chemically induced , Animals , Biocompatible Materials/administration & dosage , Collagen/biosynthesis , Connective Tissue/drug effects , Cosmetic Techniques , Dose-Response Relationship, Drug , Female , Hyaluronic Acid/administration & dosage , Kidney/drug effects , Random Allocation , Rats , Rats, Wistar , Tongue/metabolism , Viscoelastic Substances/administration & dosageABSTRACT
La mucositis es una de las complicaciones orales frecuentes en la terapia del cáncer, no obstante su tratamiento es controversial. Se ha señalado que la efectividad de algunos agentes depende de la fase de la mucositis en la que se inicia el tratamiento. El propósito de este estudio fue hacer una revisión de la literatura sobre las lesiones tenpranas eritenatosas de mucositis oral inducida por quimioterapia y/o radioterapia en pacientes pediátricos con cancer. Para tanto se realizó una revisión bibliográfica para conocer: frecuencia, diagnóstico y tratamiento de las lesiones tenpranas eritenatosas de mucositis oral en niños con cáncer. Los resultados denostraron que debido a la alta frecuencia de esta patología por ser inducida por quimioterapia en pacientes pediátricos con cáncer se cita la existencia de varios tratamientos, destacándose la utilización de la vitamina E y de laser, pudiendo ser terapias efectivas en el tratamiento de estas lesiones tenpranas de mucositis oral en pacientes pediátricos con cáncer
Mucositis is one of the frequent oral complications in the cancer therapy, however its treatment is controversial. Have been highlighted that the effectiveness of some agents depends on the mucositis development phase when the treatment is started. The purpose of this study was to do a revision on the literature regarding mucositis eritenatosas initial injuries induced by chenotherapy and/or radioteraphy in pediatric patients with cancer. A bibliographic revision was made to know: frequency, diagnosis and treatment for the oral mucositis eritenatosas initial injuries in children with cancer. The results shown that because of the high frequency of this pathology induced by chenotherapy and/or radioteraphy in pediatric patients with cancer, the existence of several treatments is highlighted, the use of vitamin E and laser stands out as an effective therapy for this oral mucositis initial injuries treatment in pediatric patients with cancer
Subject(s)
Humans , Male , Female , Child , Stomatitis/diagnosis , Stomatitis/drug therapy , Stomatitis/radiotherapy , Mouth Neoplasms/drug therapy , Mouth Neoplasms/radiotherapy , Dentistry , Drug Therapy/methods , Radiotherapy/methodsABSTRACT
AIM: This paper reports the case of a sarcomatous tumor (probably a pleomorphic sarcoma) in a patient with Neurofibromatosis type 1 (NF1) and discusses the association between these two diseases. BACKGROUND: NF1 is an autosomal dominant tumor predisposition syndrome. Malignant transformation is observed in patients with this disease, usually in the form of malignant peripheral nerve sheath tumors (MPNSTs). REPORT: A 72-year-old female patient with diagnosis of NF1 presented with left mandibular region enlarged for about 6 months, intra-oral examination revealed a mass growth on the floor of the lower left posterior area of the oral cavity measuring 5 cm in its greatest diameter and covered by ulcerated mucosa. SUMMARY: Few cases of association of neurofibromatosis with other types of soft tissue sarcomas have been reported. Undifferentiated pleomorphic sarcomas are the most common of these tumors. We intend to call attention to the importance of patient follow-up and counseling.