[The clinical laboratory indices in ancylostomiasis among the population of Kindia Prefecture (Republic of Guinea)]. / Kliniko-laboratornye pokazateli pri ankilostomidozakh u naseleniia prefektury Kindia (Gvineiskaia Respublika).

Clinical and laboratory data have been compared in patients with ankylostomiasis and healthy population of Guinea Republic. An increase in ankylostomiasis morbidity during the humid season has been observed. The clinical pattern of the disease did not differ from that earlier described in literature. Anemia and eosinophilia were the most persistent signs of the disease. The patients with ankylostomiasis revealed an elevated IgM level and a trend towards an increase in 0-lymphocyte population, which is indicative of certain shifts in cellular and humoral immunity.

[The clinico-immunological characteristics of intestinal schistosomiasis in the Republic of Guinea]. / Kliniko-immunologicheskaia kharakteristika kishechnogo shistosomoza v Gvineiskoi Respublike.

The results of clinic and immunological examination of patients with intestinal schistosomiasis at the stage of developed infection in the natives of Guinea are presented. Polymorphism of clinical manifestations was accompanied by diagnostically significant changes in hematological (eosinophilia, increased erythrocyte sedimentation rates) and immunological (higher absolute count of B lymphocytes, IgM levels, amount of T suppressors, lower Tx/Tc ratio) parameters, which, together with the results of parasitological studies, are to be taken into account during the choice of treatment and control over its efficacy.

[The results of serological research to determine hepatitis A and B markers in the blood sera of the population of the Republic of Guinea]. / Rezul'taty serologicheskikh issledovanii po opredeleniiu markerov gepatitov A i B v syvorotakh krovi naseleniia Gvineiskoi Respubliki.

The results of examinations of sera from apparently normal urban and rural residents of the Guinea Republic (GR) for markers of viral hepatitis A (anti-HAV) and B (HBsAg) are presented. The number of HBsAg-positive subjects was 16 +/- 1% (1199 serum specimens were examined by direct enzyme immunoassay, EIA, and HI test), the rate of HBsAg findings in sera from children (less than 16 years) and adults (greater than or equal to 16) did not differ significantly (p less than 0.05). The rate of a HBsAg carrier state did not depend on sex and residence of the subjects under study (p less than 0.05). The detection rate of total (IgM + IgG) anti-HAV antibody was 67 +/- 2% (812 serum specimens were examined by a variant of EIA block). The detection rate and titres of anti-HAV in children were higher than in adults, and in urban residents higher than in rural subjects (p less than 0.05). The results of detection of HBsAg and total anti-HAV antibody in the sera of GR residents are close to those obtained in examinations of sera from the populations of countries bordering GR in Western Africa (Senegal, Mali, Liberia) and are typical of Africa as a whole.