[3-substituted analogs of remantadine: synthesis and antiherpetic activity in Vero cells]. / 3-zameshchennye analogi remantadina: sintez i protivogerpeticheskaia aktivnost' v kul'ture kletok Vero.

Chemical synthesis of 3-substituted analogues of remantadine is described. Derivatives IIIb and IIIc when compared with remantadine had not only potent activity against ethalon herpes simplex type 1 virus strain but also were active against herpes virus resistant to aciclovir. Compound IIIc demonstrated virulecidal effect. Combination of IIIc + aciclovir had additive effect against ethalon herpes simplex type 1 virus strain. Investigated 3-substituted analogues demonstrated low activity in the model system of influenzae virus. No antiviral activity was demonstrated in the model system of Syndbys virus (though compounds were evaluated in subtoxic concentrations).

[Economic aspects of the treatment of acute and chronic pain syndromes in cancer patients in hospitals and outpatient clinics]. / Ekonomicheskie voprosy lecheniia ostrogo i khronicheskogo bolevykh sindromov u onkologicheskikh patsientov v statsionare i poliklinike.

Cost of treatment of pain in 1687 hospital and 400 ambulatory cancer patients was calculated. The average cost of medication for acute pain in a hospital was 1.41 roubles per conventional patient whereas for chronic pain in a polyclinic--4.31 roubles. The overall expenses were 82.55 and 18.81 roubles per conventional patient, respectively. Those expenses were formed by the cost of drugs (1.71% and 22.91%, respectively), salary (deductions included) for medical (36.92% and 61.24%) and other staff (37% and 5.8%), wear and tear (0.61% and 0.21%) and running costs (23.76% and 8.84%, respectively).

[The cost of postoperative drug analgesia of patients with cancer]. / Stoimost' medikamentoznoi analgezii v posleoperatsionnom periode u onkologicheskikh bol'nykh.

Calculation of expenses on drug analgesia based on 1687 case records of cancer patients with different tumour location (lung, esophageal, gastric, rectal, uterine and breast cancer) has revealed different structure of expenditure on days 1 to 3 of the postoperative period. On the day of surgery, 44% on average were spent on narcotic analgesics and 37% on analgin, on the 2nd and 3rd days postoperatively the ratio was 31 and 35% and 25 and 28% respectively, which to a certain extent indicates changes in postoperative pain intensity in cancer patients. The expenses on narcotic analgesics and analgin during those days were 31 and 68% of the total sum, respectively, which in absolute figures was 1 rouble 4 kopecks per patient on average. Estimation of expenses on drug analgesia in cancer patients during the first 3 days after radical surgery make it possible for the physicians to better understand the proportions of such expenditures in the budget of medical institutions.

[Blood prolactin level of breast and endometrial cancer patients during surgical intervention]. / Uroven' prolaktina krovi u bol'nykh rakom molochnoi zhelezy i éndometriia vo vremia khirurgicheskogo vmeshatel'stva.

Abundant experimental data suggest the potentiating influence of hyperprolactinemia on the development, progression and dissemination of breast cancer, whereas hypophysectomy, immunologically- and pharmacologically-induced inhibition of prolactin has an antitumor effect. Moreover, hyperprolactinemia is caused by any kind of stress (surgical one included) as well as phenothiazine and butyrophenone treatment for neuroleptanalgesia. These findings encouraged intraoperative radioimmunologic assays of blood-prolactin levels in endometrial and breast cancer patients. The advantages offered by treatment with specific inhibitors of prolactin secretion aimed at reducing hyperprolactinemia on the day of surgery are discussed.