Subject(s)
Antineoplastic Agents/toxicity , Microwaves/therapeutic use , Myeloproliferative Disorders/prevention & control , Animals , BALB 3T3 Cells , Blood Cell Count , Cytoprotection , Hematopoiesis/drug effects , Hematopoiesis/radiation effects , Liver/drug effects , Liver/pathology , Liver/radiation effects , Mice , Myeloproliferative Disorders/chemically inducedABSTRACT
The structure of the Peyer's patches and mesenteric lymph nodes of rats at different periods after polychemotherapy was investigated by light microscopy. After the use of antitumor drugs the number of the blasts and mytoses in the lymphoid follicles with the mesenteric lymph node bright centres and in the Peyer's patch follicles lowered, that along with the decrease of the size of the mantle zone in the lymph node follicles and the decrease of the area of the bright centres in the follicles of the lympoid formations in the intestinal wall was evident of the proliferation inhibition and B cells differentiation in the lymphoid organs. After the polychemotherapy the size of the germinative centres of the Payer's patch follicles decreased while the size of the mantle zone remained unchanged. The size of the mantle zone in the follicles of the mesenteric lymph nodes decreased while the size of the germinative centres did not change. The different responses of the lymphoid organs could be associated with some remote location of the lymph nodes with respect to the antigen source (damaged epithelium and intestinal lumen contents).
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Lymph Nodes/drug effects , Peyer's Patches/drug effects , Animals , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Female , Lymph Nodes/cytology , Mesentery , Peyer's Patches/cytology , Prednisolone/administration & dosage , Rats , Rats, Wistar , Vincristine/administration & dosageABSTRACT
The effects of betulonic acid, its p-alanine amide derivative, and p-alanine amide derivative of betulonic acid methyl ether on the histologic structure of rat liver have been studied on the model of experimental polychemotherapy in rats. These agents significantly decrease the dystrophic and cytolytic damage of hepatocytes and increase the repair processes in liver parenchyma.
Subject(s)
Antineoplastic Agents/adverse effects , Liver Regeneration/drug effects , Liver/injuries , Oleanolic Acid/analogs & derivatives , Animals , Antineoplastic Agents/administration & dosage , Female , Hepatocytes/metabolism , Hepatocytes/pathology , Liver/drug effects , Liver/pathology , Oleanolic Acid/administration & dosage , RatsABSTRACT
Stress substantially modulates the mononuclear phagocytic system (its center and periphery), the time of changes in granuloma formation in animals infected with BCG vaccine. This determines the specific features of development of vaccine-induced granulomatous inflammation as a reflection of changes in the host's resistance system and possibly mycobacteria. An additional influence (to Mycobacteria tuberculosis) of stresses during 30 days enhances destructive processes in the hepatic parenchyma.
