Biomechanical evaluation of a fixation technique with a modified hemicerclage for tibial tuberosity transposition: an ex vivo cadaveric study.

Objectives: (1) To determine stiffness, load at failure, and mode of failure of a novel fixation method with a tension modified-hemicerclage (MH) for tibial tuberosity transposition, and (2) to compare the biomechanical properties of this novel fixation technique to 2 pins (2Pins) and 2 pins and tension band wire fixation (2Pins + TBW). Study design: Thirty cadaveric stifles from dogs between 5.2 and 13.1 kg were assigned to 3 treatment groups: Group 1: fixation technique with MH; Group 2: 2Pins; Group 3: 2Pins + TBW. Biomechanical testing was performed with the tibia positioned at an angle of 135° relative to vertical position. Tensile force was applied to the patellar ligament until catastrophic failure was observed. The mode of failure, the load at failure, and the stiffness were compared among treatment groups. Results: The mean stiffness of the novel fixation (38.1 N/mm ± 7.1) and the 2Pins + TBW (40.2 N/mm ± 9.3) were greater than the 2Pins (26.7 N/mm ± 6.7). There was no significant difference between the novel fixation technique and 2Pins + TBW in stiffness and maximum load to failure. The 2Pins (284.3 N ± 70.5) failed at a significantly lower load than the tension modified-hemicerclage (555.7 N ± 225.9 N) and 2Pins + TBW (715.3 N ± 339.8 N). Conclusion: A fixation technique using a modified hemicerclage had the same strength and stiffness as the 2Pins + TBW and was stronger and stiffer than the 2 Pins technique in a cadaveric model.

Complications and outcomes of total hip arthroplasty in dogs with luxoid hip dysplasia: 18 cases (2010-2022).

OBJECTIVE: To describe the complications and outcomes in dogs with luxoid hip dysplasia (LH) undergoing total hip arthroplasty (THA) and compare complication rates with THA in non-LH dogs. STUDY DESIGN: Retrospective study. SAMPLE POPULATION: Client-owned dogs (n = 217) undergoing primary THA (n = 238). METHODS: Medical records (2010-2022) of dogs undergoing THA were reviewed, and LH was defined as complete dorsal displacement of the femoral head from the acetabulum on lateral projection radiographs. Major or catastrophic complications, revisions, and outcomes were recorded for all dogs and they were compared between LH and non-LH groups. RESULTS: Eighteen cases met the subcriterion for the LH group and 220 cases met the subcriterion for inclusion in the non-LH group. There were 14 complications in 13/18 dogs with LH; seven were intraoperative (femoral fissure/fracture) and seven were postoperative (dorsal luxation, n = 5; femoral fracture, n = 1; acetabular cup septic loosening, n = 1). Revisions were performed for all LH dogs that encountered complications; satisfactory outcomes were achieved in 12/13 dogs. Overall, LH dogs had a higher risk of developing complications (p < .001), including intraoperative fracture (p < .001) and postoperative dorsal luxation (p = .019) when compared with non-LH dogs. CONCLUSION: Luxoid hip dysplasia was associated with a higher risk of major complications following THA in dogs, specifically intraoperative fissure/fracture and postoperative dorsal luxation. Despite the increased risk, revisions typically yielded satisfactory outcomes. CLINICAL SIGNIFICANCE: Luxoid hip dysplasia is an important risk factor for the development of major complications in dogs undergoing THA.

Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily.

Background: The regulation of inflammatory mediators in the degenerating intervertebral disc (IVD) and corresponding ligamentum flavum (LF) is a topic of emerging interest. The study aimed to investigate the expression of a broad array of inflammatory mediators in the degenerated LF and IVD using a dog model of spontaneous degenerative disc disease (DDD) to determine potential treatment targets. Methods: LF and IVD tissues were collected from 22 normal dogs (Pfirrmann grades I and II) and 18 dogs affected by DDD (Pfirrmann grades III and IV). A qPCR gene array was used to investigate the expression of 80 inflammatory genes for LF and IVD tissues, whereafter targets of interest were investigated in additional tissue samples using qPCR, western blot (WB), and immunohistochemistry. Results: Tumor necrosis factor superfamily (TNFSF) signaling was identified as a regulated pathway in DDD, based on the significant regulation (n-fold ± SD) of various TNFSF members in the degenerated IVD, including nerve growth factor (NGF; -8 ± 10), CD40LG (464 ± 442), CD70 (341 ± 336), TNFSF Ligand 10 (9 ± 8), and RANKL/TNFSF Ligand 11 (85 ± 74). In contrast, TNFSF genes were not significantly affected in the degenerated LF compared to the control LF. Protein expression of NGF (WB) was significantly upregulated in both the degenerated LF (4.4 ± 0.5) and IVD (11.3 ± 5.6) compared to the control group. RANKL immunopositivity was significantly upregulated in advanced stages of degeneration (Thompson grades IV and V) in the nucleus pulposus and annulus fibrosus of the IVD, but not in the LF. Conclusions: DDD involves a significant upregulation of various TNFSF members, with tissue-specific expression profiles in LF and IVD tissues. The differential involvement of TNFSF members within multiple spinal tissues from the same individual provides new insights into the inflammatory processes involved in DDD and may provide a basis to formulate hypotheses for the determination of potential treatment targets.

Caudal pole meniscectomy through an arthroscopic caudomedial portal in dogs: A cadaveric study.

OBJECTIVE: To describe a caudomedial instrumental portal for caudal pole meniscectomy (CPM). STUDY DESIGN: Experimental ex-vivo study. SAMPLE POPULATION: Ten cadaveric hindlimbs of 10 large breed dogs. METHODS: Each hindlimb was used for establishing the caudomedial portal for CPM. The surgical time was recorded. Specimens were disarticulated afterwards, and the completeness of CPM was documented. Iatrogenic injuries to the articular cartilage and the intra- and periarticular structures were assessed. RESULTS: The extent of the CPM (mean ± SD, percentage of the resected medial meniscus) was 29.8 ± 12.9% of the area of the medial meniscus. There were no injuries to the medial collateral ligament or caudal cruciate ligament. The mean iatrogenic articular cartilage injury (IACI) was 3.71 ± 1.78% of the area of the medial meniscus. CONCLUSION: The establishment of a caudomedial portal for CPM in canine cadavers was feasible and allowed to perform a partial caudal pole meniscectomy. CLINICAL SIGNIFICANCE: A caudomedial portal may be considered for CPM in selected cases when caudal tears cannot be accessed through the standard portals.

Evaluation of the accuracy and intra- and interobserver reliability of three manual laxity tests for canine cranial cruciate ligament rupture-An ex vivo kinetic and kinematic study.

OBJECTIVES: To investigate the accuracy and intra- and interobserver reliability of the cranial drawer test (CD), tibial compression test (TCT), and the new tibial pivot compression test (TPCT) in an experimental setting resembling acute cranial cruciate ligament rupture (CCLR) and to elucidate the ability to subjectively estimate cranial tibial translation (CTT) during testing. STUDY DESIGN: Experimental ex vivo study. SAMPLE POPULATION: Ten cadaveric hindlimbs of large dogs. METHODS: Kinetic and 3D-kinematic data was collected while three observers performed the tests on each specimen with intact (INTACT) and transected cranial cruciate ligament (CCLD) and compared using three-way repeated-measures ANOVA. Subjectively estimated CTT (SCTT), obtained during a separate round of testing, was compared to kinematic data by Pearson correlation. RESULTS: CTT was significantly higher for CCLD than for INTACT for all tests, resulting in 100% sensitivity and specificity. TPCT induced the highest CTT and internal rotation. Intra- and interobserver agreement of translation was excellent. For rotation and kinetics, agreement was more variable. SCTT strongly correlated with the objectively measured values. CONCLUSION: The CD, TCT and the new TPCT were all accurate and reliable. The high translations and rotations during TPCT are promising, encouraging further development of this test. SCTT was reliable in our experimental setting. CLINICAL SIGNIFICANCE: Veterinary manual laxity tests are accurate and reliable in acute CCLR. The TPCT might have potential for the assessment of subtle and rotational canine stifle instabilities. The high reliability of SCTT implies that grading schemes for stifle laxity, similar to human medicine, could be developed.

Comparative kinetic and kinematic evaluation of TPLO and TPLO combined with extra-articular lateral augmentation: A biomechanical study.

OBJECTIVES: To investigate stifle kinematics and kinetics following TPLO and TPLO combined with an extra-articular lateral augmentation (TPLO-IB) during the tibial compression test (TCT) and the tibial pivot compression test (TPT), applied with an external (eTPT) and an internal moment (iTPT). STUDY DESIGN: Experimental ex vivo study. SAMPLE POPULATION: Ten cadaveric hindlimbs of dogs weighing 23-40 kg. METHODS: 3D-kinematic and kinetic data were collected while performing TCT, eTPT, and iTPT and compared under the conditions (1) normal, (2) CCL deficient, (3) TPLO, and (4) TPLO-IB. Two-way repeated-measures ANOVA was used to examine the effect of test and treatment on kinetic and kinematic data. RESULTS: Mean ± SD preoperative TPA was 24.7° ± 1.7°, postoperative TPA was 5.9° ± 0.7°. During TCT, there was no difference in cranial tibial translation between the intact stifle and after TPLO (p = .17). In contrast, cranial tibial translation was six times larger in TPLO compared to intact when performing eTPT and iTPT (p < .001). Cranial tibial translation with TCT, eTPT and iTPT was not different between intact stifle and TPLO-IB. Intraclass correlation coefficient for eTPT and iTPT after TPLO and TPLO-IB was excellent being 0.93 (0.70-0.99) and 0.91 (0.73-0.99), respectively. CONCLUSION: Whereas TCT is negative after TPLO, instability persists when a rotational moment is combined using eTPT and iTPT. TPLO-IB neutralizes craniocaudal and rotational instability when performing TCT, eTPT, and iTPT.

Outcome and Complications following Stabilization of Coxofemoral Luxations in Cats Using a Modified Hip Toggle Stabilization-A Retrospective Multicentre Study.

OBJECTIVES: The main aim of this study was to report the surgical technique, the complications and the clinical outcomes of the mini-Tight Rope system (mini-TR) for a modified hip toggle stabilization of coxofemoral luxation in cats. STUDY DESIGN: A multicentre retrospective study. ANIMALS: Thirty-two client-owned cats. METHODS: Medical records (2009-2017) of cats, which underwent stabilization of a coxofemoral luxation with the mini-TR and had at least a 3-month follow-up, were reviewed. The femoral tunnel diameter, the use of one or two FiberWire loops, perioperative complications and clinical outcomes were recorded. Follow-up information was obtained through clinical and radiographic examinations and an owner questionnaire. RESULTS: Thirty-two cats met the inclusion criteria. Concurrent injuries were present in 16 cats. A single or double loop mini-TR was used in 21 and 12 cats respectively. One double loop (1/12 cats) and four single loop (4/16 cats) sutures failed. Moderate-to-severe coxofemoral osteoarthritis developed in 14/27 cats. Owner questionnaires revealed excellent clinical outcomes. CLINICAL SIGNIFICANCE: Mini-TR with a double-stranded implant is recommended to decrease the risk of suture failure. Osteoarthritis is common after open reduction of hip luxations.

Modified toggle pin technique combined with prosthetic capsular reconstruction for surgical stabilization of coxofemoral luxation in a Shetland pony.

OBJECTIVE: To describe open reduction and surgical stabilization of a coxofemoral luxation in a pony using a modified toggle pin technique and prosthetic joint capsule reconstruction without osteotomy of the greater trochanter. ANIMAL: A 2-year-old Shetland pony with a bodyweight of 167 kg. STUDY DESIGN: Case report. METHODS: Radiographic examination confirmed craniodorsal luxation of the left coxofemoral joint. An open reduction with the aid of a pulley system was performed. A toggle pin was inserted through a bone tunnel extending from the level of the femoral shaft through the femoral head and the center of the acetabulum for the pin to be positioned on the medial wall of the acetabulum. FiberWire was subsequently passed through the cranial and caudal aspects of the acetabulum as well as a transverse tunnel in the femoral neck in a figure of 8 to facilitate capsular reconstruction. The pony was placed in a sling for 8 weeks and gradually returned to normal activity over 2 months. RESULTS: Postoperative radiographic examination confirmed the position of the femoral head in the acetabulum with the implants in place. On 2-year follow-up the pony was sound at walk and trot. CONCLUSION: A combined intra- and extra-articular stabilization technique for coxofemoral luxation in a pony resulted in successful long-term reduction and excellent outcome.

Computed tomographic measurements of the femoral trochlea in dogs with and without medial patellar luxation.

OBJECTIVES: To determine cutoff values in small (SB) and medium/large (MLB) breed dogs with and without medial patellar luxation (MPL) for identifying abnormal femoral trochlea morphology. STUDY DESIGN: Original research. ANIMALS: A total of 80 computed tomographic (CT) scans from client-owned dogs METHODS: Four groups of 20 dogs were created: (1) control SB, (2) control MLB, (3) MPL-SB, and (4) MPL-MLB. Two authors measured the femoral trochlear groove angle (FTGA), femoral trochlear angle (FTA), and femoral trochlear ridge inclination angle (FTRIA) in two points with CT. ANOVA and ROC-analysis were tested to the control and MPL groups to assess sensitivity, specificity, and cutoff values. Statistical significance was set to p < .05. Intraclass correlation coefficients evaluated the inter-rater agreement. RESULTS: FTGA (± SD) in control SB (128.8° ± 4.7°) and control MLB (119.2° ± 5.6°), was smaller (p < .0001) than in MPL-SB (139.4° ± 4.4°) and MPL-MLB (133.7° ± 5.1°). FTA and FTRIA were decreased (p = .12, p = .23) in MPL-SB (2.1° ± 6.8; -0.3° ± 3.3°) and MPL-MLB (3.8° ± 5.6°; 1.7° ± 4.5°) compared to control SB (0.2° ±4.1; -0.1° ± 2.6°) and control MLB (5.3° ± 2.8°; 3.1° ± 1.3°). Cutoff values for FTGA, FTA, and FTRIA were > 134°, < -5.9°, < -2 ° (SB), and > 128.3°, < -0.4°, < -0.4° (MLB). Sensitivity, specificity, and inter-rater agreement were superior for FTGA than FTA and FTRIA. CONCLUSIONS: Dogs without MPL had a deeper femoral trochlear groove than MPL dogs. SB had a shallower groove than MLB. The measurement of FTA and FTRIA was not reliable. CLINICAL RELEVANCE: A FTGA <134° (SB) and < 128° (MLB) may be considered as a cutoff for trochleoplasty decision-making.

Three-dimensional volume rendering planning, surgical treatment, and clinical outcomes for femoral and tibial detorsional osteotomies in dogs.

OBJECTIVES: To describe a computed tomographic (CT) methodology for planning the correction of femoral and tibial torsion and report the clinical outcomes after femoral (FDO) and tibial (TDO) detorsional osteotomy in dogs affected by torsion malalignment and patellar luxation (PL). STUDY DESIGN: Multicenter retrospective study. ANIMALS: Eighteen client-owned dogs. METHODS: Dogs underwent CT to measure femoral (FTA) and tibial torsion angle (TTA). Abnormal femoral external torsion was defined when FTA <20°, abnormal femoral internal torsion if FTA >35°; abnormal tibial external torsion was defined when TTA < -10°, and abnormal tibial internal torsion when TTA >2°. The cortical arch length (CAL) was measured with CT and used intraoperatively to determine the magnitude of correction. The medical records and radiographs were reviewed and used to report clinical and radiographic outcomes. Radiographs were reviewed to evaluate postoperative limb alignment, patellar position, and bone healing. RESULTS: Twenty-two detorsional osteotomies were performed. Mean preoperative FTA was 14° for medial-PL and 45.2° for lateral-PL. Mean preoperative TTA was 11° for medial-PL. Physiological patellar tracking was restored in 22/22 of cases. CAL measurement allowed for correction of abnormal torsion in 19/22 of cases. Seventeen out 18 dogs had full or acceptable functional outcome. The median radiographic follow-up was 3 months. Major complications occurred in 2/22 cases, which suffered an iatrogenic abnormal femoral internal torsion and a persistent hindlimb lameness. CONCLUSIONS: CAL can be measured with CT and used intraoperatively to guide the correction of abnormal torsion in dogs. CLINICAL RELEVANCE: Abnormal femoral and tibial torsion are predisposing factors for PL. A higher complication rate is expected when FDO and TDO are performed in the same hindlimb.

Ex vivo comparison of lateral plate repairs of experimental oblique ilial fractures in cats.

OBJECTIVE: To determine the biomechanical behavior of different plate systems used for oblique ilial fracture fixation in cats. STUDY DESIGN: Ex vivo biomechanical study. SAMPLE POPULATION: Fifty fresh-frozen feline hemipelvises. METHODS: Standardized simple oblique ilial fractures were created and fixed via lateral plating, using different implant systems (10 fractures in each group) The systems were: (1) the Advanced Locking Plate System (ALPS-5); (2) the Advanced Locking Plate System (ALPS-6.5); (3) the Locking Compression Plate 2.0 (LCP); (4) the FIXIN 1.9-2.5 Series (FIXIN), and (5) the Dynamic Compression Plate 2.0 (DCP). Stepwise sinusoidal cyclic loading was applied until failure (10-mm displacement). The groups were compared with regard to construct stiffness and the number of cycles withstood before 1-, 2-, 5-, and 10-mm displacement. RESULTS: Bending stiffness was lower in ALPS-5 than in other specimens (P < .05). The ALPS-6.5 specimens withstood more cycles (P < .05) before 2-, 5-, and 10-mm displacement than the ALPS-5 and DCP specimens . The LCP and FIXIN specimens endured more cycles than DCP specimens before displaying 5- and 10-mm displacement (P < .05). The ALPS-6.5, FIXIN, and LCP specimens endured higher loads before failure than the DCP specimens (P < .05). Screw loosening occurred in all nonlocking specimens, and bone slicing occurred in all locking specimens. CONCLUSION: The DCP and ALPS-5 constructs are less resistant to cyclic loading. Failure in nonlocking specimens involved screw loosening. It involved bone slicing in locking specimens. CLINICAL SIGNIFICANCE: Both the plate size and the plate-screw interface are key to lateral plating success in cases of feline ilial fractures. The use of locking plates reduces the risk of the screw loosening in such cases.

Ex vivo study of the intradiskal pressure in the C6-7 intervertebral disk after experimental destabilization and distraction-fusion of the C5-C6 vertebrae in canine cadaveric specimens.

OBJECTIVE: To evaluate intradiskal pressure (IDP) in the C6-7 intervertebral disk (IVD) after destabilization and distraction-fusion of the C5-C6 vertebrae. SAMPLE: 7 cadaveric C4-T1 vertebral specimens with no evidence of IVD disease from large-breed dogs. PROCEDURES: Specimens were mounted in a custom-made 6 degrees of freedom spinal loading simulator so the C5-C6 and C6-C7 segments remained mobile. One specimen remained untreated and was used to assess the repeatability of the IDP measurement protocol. Six specimens underwent 3 sequential configurations (untreated, partial diskectomy of the C5-6 IVD, and distraction-fusion of the C5-C6 vertebrae). Each construct was biomechanically tested under neutral, flexion, extension, and right-lateral bending loads. The IDP was measured with a pressure transducer inserted into the C6-7 IVD and compared between the nucleus pulposus and annulus fibrosus and across all 3 constructs and 4 loads. RESULTS: Compared with untreated constructs, partial diskectomy and distraction-fusion of C5-C6 decreased the mean ± SD IDP in the C6-7 IVD by 1.3 ± 1.3% and 0.8 ± 1.3%, respectively. During motion, the IDP remained fairly constant in the annulus fibrosus and increased by 3.8 ± 3.0% in the nucleus pulposus. The increase in IDP within the nucleus pulposus was numerically greatest during flexion but did not differ significantly among loading conditions. CONCLUSIONS AND CLINICAL RELEVANCE: Distraction-fusion of C5-C6 did not significantly alter the IDP of healthy C6-7 IVDs. Effects of vertebral distraction-fusion on the IDP of adjacent IVDs with degenerative changes, such as those in dogs with caudal cervical spondylomyelopathy, warrant investigation.

Ex vivo Evaluation of the Dynamic Morphometry of the Caudal Cervical Intervertebral Disc Spaces of Small Dogs and Cats.

The objective of this study was to provide a morphometric description of the caudal cervical intervertebral disc (IVD) spaces of small-breed dogs and cats. Specimens consisting of C4 through C7 from five small-breed dogs and six cats were positioned in neutral, flexion, extension, and lateral bending positions; and CT images were acquired. Height and width of the cranial and caudal vertebral endplates (VEPs), angle between the VEPs (IVD wedge angle), and craniocaudal distance (IVD width) between VEPs for the four loading positions were measured and compared for three segments (C4-C5, C5-C6, and C6-C7). VEP size normalized to body weight from medium-sized dogs was retrieved from a previous study and compared with data from small dogs and cats. A linear mixed model was used to compare outcome measures. Significance was set to p < 0.05. VEP size normalized to body weight was the largest in small dogs compared with cats (p = 0.0422) and medium-sized dogs (p = 0.0064). Cats and medium-sized dogs were similar (p = 0.2763) in this regard. Flexion and extension induced a reduction of IVD width in the ventral portion of the IVD and the area of the nucleus. The dorsal part of the IVD remained unchanged throughout loading conditions. Unique morphometric characteristics of the caudal cervical IVD space of small dogs and cats were detected that are different from those described in sizes of dogs (medium-sized) typically affected by caudal cervical spondylomyelopathy (CSM). These findings may help to understand the different pathomechanisms in cervical spinal disease between small- and medium-sized dogs, including caudal CSM.

A review of minimally invasive fracture stabilization in dogs and cats.

OBJECTIVE: To summarize and discuss peer-reviewed studies on minimally invasive osteosynthesis (MIO) of long bone, physeal, and articular fractures in dogs and cats. STUDY DESIGN: Invited review. METHODS: A critique of literature was performed to assess MIO feasibility, outcomes, and complications through PubMed, Scopus, and CAB abstracts research databases (2000-2020). RESULTS: More than 40 MIO articles have been published in the last 15 years, but most studies had small numbers, lacked control groups, and used limited outcome measures. Studies generally showed that MIO was feasible in dogs and cats with low complication rates. The current evidence does not demonstrate superior bone healing or functional outcomes with MIO when compared to standard methods. Although treatment principles, case selection, and techniques varied depending on the anatomical location, there were no salient differences in complication rates among long bones, physeal, and articular fractures treated by MIO. CONCLUSION: The current available evidence and the personal experience of the authors support MIO as a promising fracture management modality. MIO can yield excellent outcomes when applied in carefully selected cases, performed by surgeons experienced in the technique. We cannot, however, conclude that MIO is superior to open fracture stabilization based on the available evidence in veterinary literature. Randomized controlled studies are warranted to prospectively compare MIO with other osteosynthesis techniques and thereby validate its role in fracture management for dogs and cats.

Ultrasound-guided paravertebral perineural glucocorticoid injection for signs of refractory cervical pain associated with foraminal intervertebral disk protrusion in four dogs.

CASE DESCRIPTION: 4 dogs, 7.5 to 10 years of age, were presented for evaluation of signs of chronic cervical pain and forelimb lameness secondary to cervical foraminal intervertebral disk protrusion (IVDP). All dogs were refractory to ≥ 2 weeks of conservative management including strict rest and pain management with anti-inflammatory drugs, methocarbamol, and gabapentin. CLINICAL FINDINGS: The MRI findings included left foraminal IVDP at C2-3 causing mild C3 nerve root compression (dog 1), multifocal degenerative disk disease with mild focal left-sided disk protrusion at C6-7 without associated spinal cord or nerve root compression (dog 2), left foraminal C6-7 IVDP with suspected focal spinal cord atrophy or mild compression (dog 3), and right foraminal C6-7 IVDP and multifocal cervical intervertebral disk degeneration with annulus fibrosus protrusion (dog 4). TREATMENT AND OUTCOME: Ultrasound-guided paravertebral perineural injections with methylprednisolone acetate (1 mg/kg [0.45 mg/lb]) at the C3 nerve root in dog 1 and at the C7 nerve root in the other 3 dogs were performed. Injections were repeated at intervals of 4 weeks to 3 months on the basis of clinical response. None of the dogs had any complications from the procedures. For dogs 1 and 4, there was complete resolution of lameness and signs of cervical pain following perineural injections, and for dog 3, there was complete resolution of lameness and only minimal residual cervical pain. Dog 2 did not have long-lasting improvement. CLINICAL RELEVANCE: Findings indicated that ultrasound-guided paravertebral perineural injection can be an effective treatment of cervical foraminal IVDP for some dogs. Additional studies to determine appropriate case selection and better assess the overall success rate and risks associated with this technique are warranted.

Femorotibial joint kinematics in nine dogs treated with lateral suture stabilization for complete cranial cruciate ligament rupture.

OBJECTIVE: To quantify 3-D femorotibial joint kinematics during ambulation in dogs with cranial cruciate ligament (CCL) rupture treated with lateral fabellotibial suture stabilization (LFTS). ANIMALS: 9 adult dogs (body weight, 15 to 35 kg [33 to 77 lb]) with unilateral complete CCL rupture. PROCEDURES: Digital 3-D bone models of the femur and fabellae and tibia and fibula were created from CT scans. Lateral fluoroscopic images of stifle joints were collected during treadmill walking before surgery and 6 months after LFTS. The LFTS was performed with nylon leader material secured with knots. Gait cycles were analyzed with a 3-D to 2-D image registration process. Femorotibial joint kinematics (craniocaudal translation, internal-external rotation, and flexion and extension angles) were compared among CCL-deficient stifle joints before LFTS, CCL-deficient stifle joints 6 months after LFTS, and unaffected contralateral (control) stifle joints. Owners and veterinarians subjectively assessed lameness by use of a visual analog scale and gait examination, respectively, at each time point. RESULTS: At midstance phase, medial cranial tibial translation decreased from 9.3 mm before LFTS to 7.6 mm after LFTS but remained increased when compared with control stifle joint values. Following LFTS, axial rotation and stifle joint flexion and extension angles were not significantly different from control stifle joints. On the owner survey, the median walking lameness score improved from 9.3 of 10 before surgery to 0.3 after surgery. On gait examination, median walking lameness score improved from 2 of 4 before surgery to 0 after surgery. CONCLUSIONS AND CLINICAL RELEVANCE: Stifle joint instability was only slightly mitigated at 6 months following LFTS performed with knotted nylon leader material in medium to large dogs with CCL rupture, despite improvement in lameness.

A three-dimensional computed tomographic volume rendering methodology to measure the tibial torsion angle in dogs.

OBJECTIVE: To describe a three-dimensional (3D) computed tomographic (CT) methodology to measure the tibial torsion angle (TTa) and to evaluate intrarater and interrater agreements and accuracy through comparison with anatomic measurements. STUDY DESIGN: Ex vivo cadaveric study. SAMPLE POPULATION: Thirty-six tibiae from 18 dogs. METHODS: Tibial torsion angle of each tibia was measured by using two CT techniques (axial and 3D volume rendering) by three raters who blindly measured TTa in duplicate. A semitransparent bone filter was used to enhance the visibility of the target anatomical landmarks for the 3D volume rendering CT technique. Tibial torsion angle was also quantitated in tibial specimens. Intrarater and interrater agreements were analyzed by using intraclass coefficients (ICC). Accuracy was evaluated by using adjusted R2 coefficients (R2 > 80% was considered acceptable). RESULTS: The 3D volume rendering CT technique had excellent intrarater and interrater agreements (ICC > 0.94) and an R2 value of 97%. The axial CT technique had good to excellent intrarater and interrater agreements (0.8 < ICC < 0.95) and an R2 of 86%. No difference was found between axial and 3D CT techniques. A mean internal TT angle of approximately -6° was found with CT and anatomic measurements. CONCLUSION: The 3D volume rendering and axial CT techniques were precise and accurate for measuring TTa in dogs unaffected by patellar luxation. CLINICAL RELEVANCE: Combining 3D bone manipulation with application of a semitransparent filter allows simultaneous visualization of anatomic landmarks, which may facilitate the evaluation of complex bone deformations. Internal tibial torsion may be present in nonchondrodystrophic dogs without patella luxation.

Striate Artery Infarct After Bilateral Carotid Artery Ligation (BCAL) in a Dog: A Multimodal MRI Study.

Bilateral carotid artery ligation has been reported as a lifesaving procedure to control severe hemorrhage. However, reports are sparse and little information is available regarding the potential risks associated with this procedure. We report an ischemic brain infarct as a complication after vascular surgery. A 3-year old, male intact border collie was presented for acute onset of forebrain signs 5 days after bilateral carotid artery ligation. Multimodal brain MRI including morphologic sequences, MR angiography, diffusion- and perfusion-weighted images were performed. MRI revealed a well-defined intra-axial lesion of the left caudate nucleus, with increased T2 and decreased T1 signal intensity and moderate heterogeneous peripheral contrast enhancement. The cerebral blood flow was reduced relative to the contralateral caudate nucleus. Images were consistent with a subacute lacunar ischemic infarct of the left striate artery. Additionally, multiple arterio-arterial anastomosis arising from the vertebral arteries were visible in the angiography sequences. Ischemic infarct due to thromboembolism should be considered as a possible complication associated with bilateral carotid artery ligation. Collateral blood supply can develop as early as 5 days after surgery.

Biomechanical comparison of ex vivo lumbar vertebral fracture luxations stabilized with tension band or polymethylmethacrylate in cats.

OBJECTIVE: To evaluate spinal stabilization with tension band stabilization (TS) in cats compared to screw and polymethylmethacrylate fixation (SP). STUDY DESIGN: Ex vivo study. SAMPLE POPULATION: Sixteen feline thoracolumbar spinal specimens. METHODS: The intact specimens were mounted in a six-degree-of-freedom biaxial testing machine for nondestructive testing to obtain the neutral zones (NZ) and range of motion (ROM) in flexion and extension. Thereafter, nondestructive testing was consecutively performed after destabilization by disc fenestration and partial L1 corpectomy and after treatment with either TS or SP. Load to failure was compared after surgical treatment in flexion. Significance was assessed by Student's t test or Wilcoxon signed-rank test. RESULTS: Range of motion was 26.4° ± 2.2° in TS constructs and 13.4° ± 2.1° in SP constructs (P = .0005). When flexion and extension were analyzed separately, no difference was found for ROM in flexion (SP, 7.0° ± 3.7°; TS, 8.3° ± 2.1°; P = .38). In extension, the mean displacement was 6.4° ± 2.7° and 18.1° ± 5.1° in SP and TS constructs, respectively (P = .0001). Neutral zone was 2.9° ± 0.6° and 7.5° ± 0.8° for the SP and TS groups, respectively (P = .0003). Screw and polymethylmethacrylate fixation constructs were two times stiffer (P = .045). CONCLUSION: Tension band stabilization provided stability comparable to SP in flexion. In extension, ROM of SP constructs was half that of TS constructs. The mode of failure of TS was related to the limited dorsal bone stock of feline lumbar vertebrae. CLINICAL SIGNIFICANCE: Surgeons should be aware of the limited stability in extension provided by TS when it is used to stabilize thoracolumbar spinal injuries. Our results provide evidence to justify additional studies to clarify the type of fractures amenable to TS.

Evaluation of agreement and correlation of results obtained with MRI-based and macroscopic observation-based grading schemes when used to assess intervertebral disk degeneration in cats.

OBJECTIVE: To evaluate agreement in results obtained with an MRI-based grading scheme and a macroscopic observation-based grading scheme when used to assess intervertebral disk (IVD) degeneration in cats. SAMPLE: 241 MRI and 143 macroscopic images of singular IVDs in 44 client-owned cats (40 cadaveric and 4 live). PROCEDURES: Singular images of IVDs were obtained of live cats admitted for treatment of suspected neurologic disease (MRI images of IVDs) and of cadavers of cats euthanized for reasons unrelated to spinal disease (MRI and macroscopic images of IVDs) at the Small Animal Hospital, Vetsuisse Faculty, Zurich, Switzerland, between January 12, 2015, and October 19, 2015. The IVD images were randomized and evaluated twice by 4 observers for each grading scheme. Inter- and intraobserver reliability for the grading schemes was assessed with Cohen weighted κ analysis. Agreement and correlation between results obtained with the 2 grading schemes were determined with Cohen weighted κ and Spearman correlation coefficient (ρ) analyses, respectively. RESULTS: Inter- and intraobserver agreement between results was substantial to almost perfect (mean weighted κ, 0.66 to 0.83 and 0.71 to 0.86, respectively) for the MRI-based grading scheme and moderate to substantial (mean weighted κ, 0.42 to 0.80 and 0.65 to 0.79, respectively) for the macroscopic observation-based grading scheme. Between the 2 grading schemes, agreement in results was moderate (mean ± SE weighted κ, 0.56 ± 0.05), and the correlation was strong (ρ = 0.73). CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that the MRI-based and macroscopic observation-based grading schemes used in the present study could be used reliably for classifying IVD degeneration in cats.