ABSTRACT
OBJECTIVES: To demonstrate the use of urine congophilia quantification in the prediction and diagnosis of pre-eclampsia using Congo red dot test. STUDY DESIGN: A prospective cohort study in 378 consecutive pregnant women was conducted. All eligible, consenting women of gestational age between 10 and 34â¯weeks were enrolled in the study. The presence of urinary misfolded proteins was screened by a simple dot test technique on unsupported nitrocellulose membrane using Congo red dye. RESULTS: The urinary congophilia was increased in urine from women with pre eclampsia compared to healthy pregnant controls. The mean CRR value of pre eclamptic pregnant women (35.2⯱â¯9.4%) was five times higher than that of mean CRR value of normotensive pregnant women (6.9⯱â¯4.7%). The mean gestational age at which Congo red test showed positive was 26.95⯱â¯2.90â¯weeks and the time taken from CRD positive to development of PE was 4.92⯱â¯2.54â¯weeks of gestation. CONCLUSIONS: In our study, the CRD test was not only effective in predicting pre-eclampsia but was also useful in differentiating between pre-eclampsia and other forms of hypertension, as well as early onset and late onset pre-eclampsia, with positive predictive value of 80.36% and negative predictive value of 92.86.
Subject(s)
Congo Red , Pre-Eclampsia/diagnosis , Prenatal Diagnosis , Adolescent , Adult , Cohort Studies , Female , Humans , India , Pre-Eclampsia/urine , Predictive Value of Tests , Pregnancy , Prospective Studies , Tertiary Care Centers , UrinalysisABSTRACT
We report a case of non-ketotic hyperosmolar coma, which presented with blood sugar levels far exceeding any previously recorded in the literature. The patient developed acute renal failure, probably because of rhabdomyolysis, which was successfully managed with continuous veno-venous haemofiltration. He developed blurring of vision resulting from biochemical changes, which was managed conservatively. We discuss the mechanisms of causation of the renal failure and visual blurring.
Subject(s)
Critical Care , Hyperglycemic Hyperosmolar Nonketotic Coma/therapy , Acute Kidney Injury/etiology , Acute Kidney Injury/therapy , Blood Glucose/analysis , Fluid Therapy , Follow-Up Studies , Hemofiltration , Humans , Hyperglycemic Hyperosmolar Nonketotic Coma/blood , Hyperglycemic Hyperosmolar Nonketotic Coma/complications , Insulin/therapeutic use , Intermittent Positive-Pressure Ventilation , Male , Middle Aged , Rhabdomyolysis/complications , Vision Disorders/etiologyABSTRACT
Phycomycosis of the skin manifested as a spontaneous solitary ulcer of the leg in a patient with uremia. The infection later spread to the lungs and produced fatal pulmonary infarction. Histopathologic study of the lesions revealed broad nonseptate fungal hyphae that had invaded vascular channels, with areas of necrosis and acute inflammation. Primary cutaneous phycomycosis is rare. In the studied cases, dissemination of infection did not occur. The unusual feature of fatal pulmonary dissemination of primary cutaneous phycomycosis as observed in our patient has not been described in the leterature.
