On the Ion Implantation Synthesis of Ag-Embedded Over Sr-Substituted Hydroxyapatite on a Nano-Topography Patterned Ti for Application in Acetabular Fracture Sites.

Introduction: There is an ongoing need for improved healing response and expedited osseointegration on the Ti implants in acetabular fracture sites. To achieve adequate bonding and mechanical stability between the implant surface and the acetabular fracture, a new coating technology must be developed to promote bone integration and prevent bacterial growth. Methods: A cylindrical Ti substrate mounted on a rotating specimen holder was used to implant Ca2+, P2+, and Sr2+ ions at energies of 100 KeV, 75 KeV and 180 KeV, respectively, using a low-energy accelerator to synthesize strontium-substituted hydroxyapatite at varying conditions. Ag2+ ions of energy 100 KeV were subsequently implanted on the as-formed surface at the near-surface region to provide anti-bacterial properties to the as-formed specimen. Results: The properties of the as-formed ion-implanted specimen were compared with the SrHA-Ag synthesized specimens by cathodic deposition and low-temperature high-speed collision technique. The adhesion strength of the ion-implanted specimen was 43 ± 2.3 MPa, which is well above the ASTM standard for Ca-P coating on Ti. Live/dead cell analysis showed higher osteoblast activity on the ion-implanted specimen than the other two. Ag in the SrHA implanted Ti by ion implantation process showed superior antibacterial activity. Discussion: In the ion implantation technique, nano-topography patterned surfaces are not concealed after implantation, and their efficacy in interacting with the osteoblasts is retained. Although all three studies examined the antibacterial effects of Ag2+ ions and the ability to promote bone tissue formation by MC3T3-E1 cells on SrHA-Ag/Ti surfaces, ion implantation techniques demonstrated superior ability. The synthesized specimen can be used as an effective implant in acetabular fracture sites based on their mechanical and biological properties.

Laser power and high-temperature dependent Raman studies of layered bismuth and copper-based oxytellurides for optoelectronic applications.

Layered metal oxychalcogenide materials have gained significant attention in recent years due to their numerous applications in various emerging fields. The bismuth (Bi) based ternary and quaternary oxychalcogenide materials have become popular due to their excellent potential in optoelectronic, thermoelectric, and semiconducting applications. Adding copper (Cu) to these building matrices has enhanced their usefulness in various ways. In this work, Bi and Cu-based ternary and quaternary layered oxytellurides are synthesized using a unique, rarely used "microwave (MW) assisted method," and their temperature and laser power-dependent Raman measurements are carried out. All the samples are prepared at the same MW power and at a fixed irradiation time. Crystallographic studies show that the good crystallinity of the synthesized materials matches well with the phases reported previously. Nanosheet-like morphology was observed for all the prepared samples. The optical properties and band gap energies of these materials were obtained using the diffuse reflectance spectroscopy technique, which are in the range of 1.15-2.52 eV. The photoluminescence spectrum shows broad peaks around orange-red regions, indicating the potential applicability of these materials in various optoelectronic applications. The effect of high temperature and laser power on the Raman spectra of the oxytellurides is demonstrated, where the appearance of different vibrational modes along with a redshift in peak positions with the increase in temperature and power is observed.

Congenital brain tumour in a neonate: a therapeutic challenge.

A term neonate with history of ventriculomegaly in the fetal period was diagnosed with a central nervous system tumour after radiological investigations. It was confirmed as an immature teratoma after histopathological examination. He underwent left frontal craniotomy with tumour excision. Intraoperatively, massive haemorrhage (venous bleed) occurred due to the high vascularity of the tumour and led to haemodynamic instability. A massive transfusion protocol was initiated. Despite multiple transfusions and shock management, he succumbed at 2 weeks of life. This case report highlights the importance of antenatal diagnosis and fetal MRI in prognostication and also the possible role of neoadjuvant chemotherapy in reducing tumour vascularity and, hence, bleeding.