ABSTRACT
The anti-inflammatory effect of Causticum was evaluated using acute and chronic inflammatory models in vivo. The administration of concentrated Causticum solution into the hind paw of rats produced an inflammatory reaction with oedema formation within the first hour, showing that Causticum acts as an oedematogenic agent. Carrageenin induced rat paw oedema was significantly inhibited (P<0.05) in the group treated with Causticum 30cH solution compared to control. Groups treated with potentized Causticum (6cH, 12cH, 30cH and 200cH), showed significant inhibition (P<0.05) of the inflammation pre-induced by carrageenin. However pre-treatment with Causticum 30cH for 6 days (0.5 ml, daily) did not significantly inhibit granulation using an implantation method.
Subject(s)
Anti-Inflammatory Agents/administration & dosage , Calcium Hydroxide/pharmacology , Edema/drug therapy , Foot Diseases/chemically induced , Inflammation/drug therapy , Phytotherapy , Plant Extracts/administration & dosage , Potassium Compounds/pharmacology , Animals , Calcium Hydroxide/administration & dosage , Carrageenan , Disease Models, Animal , Dose-Response Relationship, Drug , Edema/chemically induced , Granulation Tissue/drug effects , Inflammation/chemically induced , Male , Potassium Compounds/administration & dosage , Random Allocation , Rats , Rats, Wistar , Time FactorsABSTRACT
The anti-inflammatory effect of Causticum was evaluated using acute and chronic inflammatory models in vivo. The administration of concentrated Causticum solution into the hind paw of rats produced an inflammatory reaction with oedema formation within the first hour, showing..(AU)
