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1.
Psychol Aging ; 16(1): 85-95, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11302370

ABSTRACT

In 2 person perception experiments, young and older perceivers read a scenario about a young or old female target who leaves a store without paying for a hat. In Experiment 1, the target claims she forgot she was wearing the hat when questioned by the manager. Perceivers thought the manager would have greater sympathy, less anger, and would recommend less punishment when the target was old. In Experiment 2, the target clearly forgot to pay for the hat, clearly stole it, or had ambiguous intentions. In the ambiguous condition, perceivers attributed the young target's behavior more to stealing and the old target's behavior more to forgetting. In the forget condition, young perceivers had equal sympathy for the young and old targets and held them similarly responsible, but older perceivers had greater sympathy for the forgetful old target and held her less responsible than they did the forgetful young target.


Subject(s)
Behavior , Judgment , Memory/physiology , Motivation , Social Perception , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged
2.
Int J Aging Hum Dev ; 50(3): 201-14, 2000.
Article in English | MEDLINE | ID: mdl-10987342

ABSTRACT

Either before or after being interviewed for a volunteer position, a young or old protagonist (i.e., target) gave an excuse for forgetting. Study participants (i.e., perceivers) had a higher opinion of the target's memory, were more confident in the target's capability of performing memory-related tasks, and attributed the target's memory failures more to bad luck when the excuse was given after (damage-control strategy) rather than before (self-handicapping strategy) the interview. Moreover, the excuse given before the interview had no significant effect on perceivers' judgments when compared with data from an earlier study in which the target gave no excuse for forgetting. The present findings suggest that a damage-control strategy can ameliorate negative capability impressions.


Subject(s)
Aging/psychology , Memory Disorders/psychology , Rationalization , Social Perception , Volunteers/psychology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Florida , Humans , Male , Middle Aged
3.
Int Immunol ; 10(8): 1093-101, 1998 Aug.
Article in English | MEDLINE | ID: mdl-9723695

ABSTRACT

NK cells not only function as cytotoxic effector cells, but also have immunoregulatory roles including the enhancement of Ig secretion. To have a stable and uniform population of NK cells to study their role in Ig secretion, we generated murine NK clones. Thus, culture of splenocytes from mice that were homozygous for a mutation in the p53 tumor suppressor gene (p53-KO) with IL-2 and poly(IC) resulted in a long-term NK line, from which four stable clones were derived. This approach also yielded a long-term NK line from splenocytes of normal C57BL/6 mice. Identification of the clones as members of the NK lineage was based on large granular morphology, expression of NK-TR and absence of TCR gene rearrangement. Flow cytometry revealed that all clones expressed IL-2R alpha and beta, chains and B220, but no CD3, NK1.1, DX5 or Ly-49. RT-PCR analysis showed heterogeneity in NK1.1 gene expression, and demonstrated expression of perforin and several granzymes in all clones. Three out of four clones lysed YAC-1, but not P815 target cells, corresponding to a pattern of NK specificity. All NK clones enhanced Ig secretion in an in vitro model for T cell-independent type 2 antigens, albeit to varying degrees. We found no correlation between the degree of helper activity of the NK clones and the level of their cytotoxic activity on YAC-1 targets. Thus, we established murine NK clones, and show that they mediate both cytotoxicity and enhancement of Ig secretion.


Subject(s)
Antigens, Ly , Cytotoxicity, Immunologic , Immunoglobulin M/biosynthesis , Killer Cells, Natural/immunology , Animals , Antigens/analysis , Antigens/genetics , Antigens, CD/analysis , Antigens, Surface , B-Lymphocytes/immunology , Blood Proteins/genetics , Clone Cells , Flow Cytometry , Genes, T-Cell Receptor beta/genetics , Immunoglobulin M/analysis , Lectins, C-Type , Leukocyte Common Antigens/analysis , Membrane Glycoproteins/analysis , Membrane Glycoproteins/genetics , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Mice, Knockout , NK Cell Lectin-Like Receptor Subfamily B , Perforin , Pore Forming Cytotoxic Proteins , Proteins/analysis , Proteins/genetics , Receptors, Interleukin-2/analysis , Receptors, NK Cell Lectin-Like , Receptors, Natural Killer Cell , Serine Endopeptidases/genetics , Spleen/immunology , Tumor Suppressor Protein p53/genetics
4.
J Gerontol B Psychol Sci Soc Sci ; 52(6): P303-7, 1997 Nov.
Article in English | MEDLINE | ID: mdl-9403519

ABSTRACT

Young and older perceivers read a narrative in which a forgetful young or old target was described as having either a young or old life style. Perceivers attributed memory failures more to mental difficulty for old targets but to lack of effort for young targets, regardless of life style. Life style did make a difference in perceivers' memory opinion and sympathy for the old but not for the young targets. Perceivers had a less negative memory opinion when the old target had an old rather than a young life style. Also, the old target with the old life style elicited a greater degree of sympathy in young perceivers, but a lesser degree of sympathy in older perceivers.


Subject(s)
Aging , Life Style , Memory Disorders , Adolescent , Adult , Aged , Anger , Female , Humans , Male , Memory Disorders/diagnosis , Middle Aged , Neuropsychological Tests
5.
Exp Aging Res ; 23(4): 355-67, 1997.
Article in English | MEDLINE | ID: mdl-9352292

ABSTRACT

Perceivers were assigned to one of two decision conditions. In an absolute decision condition, perceivers rated how likely they would be to allow a young or old highly forgetful, slightly forgetful, or nonforgetful target to perform a challenging task. In a comparison decision condition, perceivers rated two targets, one young and one old, who had a similar level of forgetfulness. Separate Decision Type x Target Forgetfulness analyses of variance were conducted on ratings of the two target age groups. Young targets received higher ratings in the comparison than in the absolute condition, whereas old targets were rated the same in the two conditions. There was some preference for young targets in a comparison situation, but it was concluded that forgetfulness was a more important factor than age in perceivers' ratings.


Subject(s)
Aging/physiology , Memory/physiology , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged
6.
Exp Aging Res ; 23(1): 1-12, 1997.
Article in English | MEDLINE | ID: mdl-9049609

ABSTRACT

Participants (i.e., perceivers) unscrambled either memory-related phrases (experimental group) or memory-neutral phrases (control group). Then perceivers read a vignette about a forgetful young, middle-aged, or old target person, after which they rated (a) the target's forgetfulness and (b) how difficult each of 12 tasks (4 low, 4 medium, and 4 high in memory load) would be for the target. High-memory-load tasks were rated as more difficult by perceivers in the experimental group than by perceivers in the control group. Thus, implicit priming of a forgetfulness schema resulted in harsher judgments about how difficult high-memory-load tasks would be for forgetful targets. However, this priming effect was no stronger for old than for young or middle-aged targets.


Subject(s)
Aging/psychology , Memory/physiology , Adolescent , Adult , Age Factors , Female , Humans , Male , Middle Aged , Task Performance and Analysis
7.
Psychol Aging ; 11(2): 310-5, 1996 Jun.
Article in English | MEDLINE | ID: mdl-8795059

ABSTRACT

Perceivers read a script of a forgetful young, middle-aged, or older male or female target being interviewed for a volunteer position. Afterward perceivers rated their opinion of the target's memory, confidence in the target's capability of performing tasks, and attributions for the target's memory failures. Perceivers were more confident and attributed failures more to lack of effort and attention when targets experienced episodic than semantic memory failures. Perceivers' memory opinion was less negative for older than for young and middle-aged targets, but their confidence ratings were equivalent across target age groups. Perceivers used an age-based double standard in their attribution ratings. However, double-standard evidence was not as strong as in prior studies using less evaluative contexts.


Subject(s)
Aging , Memory Disorders/diagnosis , Adolescent , Adult , Age Factors , Aged , Female , Humans , Male , Middle Aged
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