Subject(s)
Breast Neoplasms/therapy , Carcinoma/therapy , Neoplasm Recurrence, Local/epidemiology , Radiation Dose Hypofractionation , Radiation Injuries/epidemiology , Radiotherapy Planning, Computer-Assisted/methods , Adult , Aged , Breast/pathology , Breast/radiation effects , Breast/surgery , Breast Neoplasms/mortality , Carcinoma/mortality , Disease-Free Survival , Female , Humans , Mastectomy, Radical , Middle Aged , Neoplasm Recurrence, Local/prevention & control , Practice Patterns, Physicians'/statistics & numerical data , Radiation Injuries/etiology , Radiation Injuries/prevention & control , Radiotherapy Planning, Computer-Assisted/statistics & numerical data , Time Factors , Young AdultSubject(s)
HIV Infections , CD4 Lymphocyte Count , HIV Infections/complications , Humans , Viral LoadABSTRACT
Mycobacteria are intrinsically resistant to most antibiotics as a result of multiple mechanisms. Linezolid, a member of the oxazolidinones, is a newer class of synthetic antimicrobials which is frequently used to treat mycobacteria. Here, we report a case of a patient with an ulcer on the right arm, caused by atypical mycobacteria, who presented with discoloration of both the upper and lower teeth after being treated with linezolid for a period of 2 months. On detailed evaluation, the patient was found to have linezolid-induced dental hyperpigmentation. This is the first case reported ever in an adult having linezolid-induced dental hyperpigmentation.
ABSTRACT
BACKGROUND: Tuberculosis (TB) is one of the common infections in the world, especially in developing countries like India. Therefore, early diagnosis is important. This study was undertaken to compare the yield of sputum, induction with bronchoalveolar lavage (BAL) in smear-negative suspected pulmonary TB patients in a tertiary care hospital in Agra. METHODS: Fifty patients were included in the study. In all patients, induced sputum, fibreoptic bronchoscopy and BAL fluid were subjected to diagnostic testing. RESULTS: On acid-fast smear examination, induced sputum and BAL fluid tested positive in 27/50 and 25/50 patients, respectively with a sensitivity of 83.3% and 90% respectively (p<0.0001). On comparing sputum induction versus BAL on culture, 30 patients were positive by sputum induction and 27 patients were positive on BAL fluid, with the sensitivity of 85.7% and 77.1%, respectively. The results showed that the sputum induction showed a significantly higher yield than that of BAL fluid (p=0.0013). CONCLUSION: Sputum induction offers an alternative approach in the diagnosis of smear-negative suspected pulmonary TB patients and would enhance sensitivity for the diagnosis of TB.
