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1.
Vet Med Nauki ; 21(4): 63-8, 1984.
Article in Bulgarian | MEDLINE | ID: mdl-6740933

ABSTRACT

Biopharmaceutic and therapeutic investigations were carried out with foaming and nonfoaming gentamycin sulfate tablets. The experiments were conducted with a total of 100 cows affected with chronic inflammation of the uterus. Both types of tablets, containing 30,000 IU of gentamycin sulfate each were introduced into the uterus via Andreev's catheter, bimanually or by means of a vaginal speculum and Albrechtzen's clamp, at the rate of 10. Followed up were the serum levels, the excretion with the milk, and the content in the uterine secretion of gentamycin after using the tablets. There was no statistically significant difference in the serum levels of gentamycin as initiated by the two types of tablets. In milk the peak values reached 0.02 micrograms/cm3, and in uterine washings (with 15 cm3 isotonic solution of sodium chloride) the proper levels were established up to 74nd hour. Demonstrated was the therapeutic effect in the treatment of cows with chronic endometritis - 77.4 per cent with the use of foaming and 71.4 per cent with the use of nonfoaming tablets. There was also a rising trend with the conception rate in the treatment of sterile cows (otherwise having no signs of uterine inflammation) with the use of nonfoaming tablets of gentamycin sulfate at the rate of 5, introduced 24 hours after insemination.


Subject(s)
Cattle Diseases/drug therapy , Endometritis/veterinary , Gentamicins/administration & dosage , Animals , Biopharmaceutics , Cattle , Cattle Diseases/metabolism , Chronic Disease , Drug Evaluation/veterinary , Endometritis/drug therapy , Endometritis/metabolism , Female , Gentamicins/metabolism , Kinetics , Pharmaceutic Aids , Pregnancy , Tablets , Time Factors
2.
Vet Med Nauki ; 16(9): 42-9, 1979.
Article in Russian | MEDLINE | ID: mdl-545853

ABSTRACT

A study on the distribution of symptomless mastitis in cows on its forms and onthe percentage involvement of the individual microorganisms isolated in the positively reacting cases was carried out including clinical, cytological and microbiological investigations. The study covered 8 cow farms with a total number of 2377 cows. It was established that 68.42% of the cows suffer from symptomless mastitis and 24.09% of the udder quarters. In 32.39% of the latter cases non-specific mastitis or the so called secretory disturbance was observed, while in 67.61%--bacterial mastitis, which in 50.75% had a subclinical course, while in 17.36--as latent infection. In the samples with pathogenic microorganisms 72.35% had staphylococci, 14.32%--micrococci, 8.39%--streptococci and the remaining 4.94%--other kinds of bacteria. The appearance and distribution of symptomless mastitis in cows is the result of bad management of cow rearing and use.


Subject(s)
Mastitis, Bovine/epidemiology , Animals , Bulgaria , Cattle , Female , Mammary Glands, Animal/microbiology , Mastitis, Bovine/microbiology , Milk/microbiology
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