ABSTRACT
Hepatotoxicity of cyamamezine, a phenothiazine structurally related to chlorpromazine, has been rarely documented. We report here a case of acute symptomatic hepatitis following a unique massive intake of cyamamezine in a suicide attempt and discuss the mechanisms of such injury.
Subject(s)
Chemical and Drug Induced Liver Injury/etiology , Phenothiazines/poisoning , Acute Disease , Adult , Chemical and Drug Induced Liver Injury/pathology , Female , Humans , Liver/pathology , Suicide, AttemptedABSTRACT
Two cases of severe hepatitis in young women using Atrium and paroxetine are presented. Both patients presented jaundice, marked increase in aminotransferases activities, and pronounced prolongation in prothrombin time. In both cases, liver biopsy specimen examination revealed lesions compatible with drug-related injury. Other causes of hepatic injury were reasonably ruled out by complete careful screening. Outcome was marked by rapid complete recovery in one case and by slow recovery in the other. We suggest that simultaneous treatment with Atrium and paroxetine could increase each of these drugs' hepatotoxicity.
Subject(s)
Anti-Anxiety Agents/adverse effects , Barbiturates/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Paroxetine/adverse effects , Phenobarbital/adverse effects , Selective Serotonin Reuptake Inhibitors/adverse effects , Adult , Anti-Anxiety Agents/administration & dosage , Barbiturates/administration & dosage , Chemical and Drug Induced Liver Injury/pathology , Drug Combinations , Drug Interactions , Female , Humans , Liver/pathology , Paroxetine/administration & dosage , Phenobarbital/administration & dosage , Selective Serotonin Reuptake Inhibitors/administration & dosageABSTRACT
Paracetamol is a widely used medication as it is an effective analgesic and antipyretic. Because of the absence of gastro-intestinal side effects, it has been used as the analgesic of choice for alcoholic patients. Hepatotoxicity is dose-related and generally occurs in patients who absorb more than 125 mg/kg/j. However, cases of severe liver damage have been reported after absorption of therapeutic doses of paracetamol in alcoholics. We report 2 cases with a fatal outcome and discuss the mechanisms of toxicity, the prognostic factors and treatment of such event.
