ABSTRACT
A new ligand N-salicyloyl-N'-(p-hydroxybenzthioyl) hydrazine (H2STPH) and its Cu(II) complex [Cu(SPTH)] were prepared and characterized by analytical and physicochemical studies. In vivo antitumor activity of [Cu(STPH)] has been tested against breast tumor in C3H/J strain mice and in vitro on P-815 (murine mastocytoma) and K-562 (human erythroleukemia) cells. LD50 values were estimated at a dose level of 100 mg/kg body weight and a light microscopic study also carried out.
Subject(s)
Antineoplastic Agents/pharmacology , Copper/chemistry , Hydrazines/chemistry , Organometallic Compounds/chemistry , Salicylamides/chemistry , Animals , Antineoplastic Agents/chemistry , Antineoplastic Agents/therapeutic use , Electron Spin Resonance Spectroscopy , Female , Humans , Leukemia, Erythroblastic, Acute/pathology , Magnetic Resonance Spectroscopy , Mammary Neoplasms, Experimental/drug therapy , Mast-Cell Sarcoma/drug therapy , Mast-Cell Sarcoma/pathology , Mice , Mice, Inbred C3H , Spectrophotometry, Infrared , Tumor Cells, CulturedABSTRACT
The Vasti therapy is highly effective in the management of benign prostate Hyperplasia. It deceases the weight-of prostate, residual urine and free serum testosterone level.
Subject(s)
Brain/metabolism , Craniocerebral Trauma/metabolism , Serotonin/metabolism , Animals , Brain Mapping , DogsSubject(s)
Breast Neoplasms/blood , Melatonin/blood , Thyroid Hormones/blood , Adult , Female , Humans , Middle AgedSubject(s)
Acetylcholine/metabolism , Brain/radiation effects , Iodides/pharmacology , Iodine Radioisotopes , Serotonin/metabolism , Stress, Physiological/metabolism , Animals , Brain/drug effects , Brain/metabolism , Female , Iodine Radioisotopes/administration & dosage , Rats , Rats, Inbred StrainsSubject(s)
Brain Neoplasms/blood , Neurotransmitter Agents/blood , Adolescent , Adult , Child , Child, Preschool , Female , Glutamate Decarboxylase/blood , Glutamates/blood , Humans , Infant , Infant, Newborn , Male , Middle Aged , Monoamine Oxidase/blood , Serotonin/blood , gamma-Aminobutyric Acid/bloodABSTRACT
The results of this study indicate that melatonin induces hypothyroidism in mice within eight days. Simultaneous administration of melatonin and petroleum ether extract of Commiphora mukul brings about a significant improvement in thyroid structure and function. Further, melatonin induced hypothyroidism is although a little reversible yet it is normalized quickly after C. mukul treatment. These data suggest that C. mukul directly stimulates thyroid function probably through some enzymatic mechanisms.
ABSTRACT
The knowledge and management of the disease, cancer was not unknown to the ancient surgeons of India. Though the Sanskrit equivalent for this word is not found in Ayurvedic literature, diseases having the signs and symptoms similar to those of Cancer are discussed in various contexts. The present paper expounds those diseases with possible interpretations in modern system of medicine.
ABSTRACT
The results of this study has revealed a significant increase in I(131) uptake of cultivated thyroid gland in the media containing petroleum ether extract of Commiphora mukul. Besides, T(3) resin uptake, protein bound iodine as well as free thyroxine index in the media are also observed to be significantly (P 0.001) increased. When explants are cultivated in the media containing melatonin, there is significant depression in thyroid I(131) uptake and media T(3) resin uptake, protein bound iodine as well as free thyroxine index. Further, the inhibitory action of melatonin has been antagonized when similar explants are cultivated in the media containing melatonin and P.E. extract of c. mukul together thus, C. mukul may be useful in the management of hypothyroidism and its associated disorders like, hypercholesterolemia, hyperlipidemia, atherosclerosis etc.
Subject(s)
Pineal Gland/physiopathology , Stress, Psychological/physiopathology , Thyroid Gland/physiopathology , Animals , Female , Humans , Male , Rats , ThyroidectomyABSTRACT
Considering the therapeutic aspects of thyrotoxicosis, 980 cases were studied, where probable role of stress in the etiopathogenesis has been explored. These cases were then treated with standard modern therapy containing antithyroid drug with a tranquilizer and some of the patients were treated only by an Ayurvedic drug. i. e. Sankhapuspi. In early cases Sankhapuspi was found more effective than standard modern treatment. In addition, no side effect was noted in these patients treated with Sankhapuspi.
ABSTRACT
The present study includes 50 patients suffering from psychological stress disorders like thyrotoxicosis and anxiety neurosis. Biochemical estimation of melatonin was done in all these cases prior to treatment and 3 months after appropriate treatment. A significant increase in the level of melatonin was observed in thyrotoxic and anxiety neurotic cases. In all these cases, after therapy the level of melatonin was found to be within the normal limits. These observations confirm the finding that there is a pineal response to psychic stress.
