On mitigation of earthquake and landslide hazards in the eastern Himalayan region.

Mitigation of geological hazards through science and engineering applications is one of the most effective ways to reduce their impact on human life and local infrastructure. It involves precise mapping of hazards, assessment of their potential, monitoring, early warning, geotechnical treatment, design of vital infrastructural facilities and creating awareness at local levels. Several such initiatives have been taken at government level to deal with the earthquakes and landslides in the eastern Himalayan region. These efforts facilitated identification of potential areas and sites, susceptible to future events and helped in improving our understanding of crustal structure, geodynamics, tectonics, seismogenesis, and soil properties, etc. The paper highlights details of the major initiatives, significant achievements, and priorities to help in better mitigation of earthquake and landslide hazards in the eastern Himalayan region.

Revealing the nature of thio-click reactions on the solid phase.

Thiol- and yne-functionalized beads were manufactured in a simple microfluidic setup. While CuAAC and thiol-yne reactions were performed on yne-functionalized beads, 9 different thiol-X reactions were compared, in terms of kinetics and conversion, on thiol-functionalized beads.

Multidentate macromolecules for functionalisation, passivation and labelling of metal nanoparticles.

A new class of SERRS-active macromolecule designed to protect silver nanoparticle surfaces against salt corrosion whilst retaining colloidal stability of the particles is reported.

SERRS labelled beads for multiplex detection.

Beads labelled using surface enhanced resonance Raman scattering (SERRS) are highly sensitive and specific tags, with potential applications in biological assays, including molecular diagnostics. The beads consist of a nucleus containing dye labelled silver-nanoparticle aggregates surrounded by a polymer core. The nuclei generate strong SERRS signals. To illustrate the coding advantage created by the sharp, molecularly specific SERRS signals, four specially designed SERRS dyes have been used as labels and three of these have been combined in a multiplex analysis. These dyes use specific groups such as benzotriazole and 8-hydroxyquinoline to improve binding to the surface of the silver particles. The aggregation state of the particles is held constant by the polymer core, this nucleus also contains many dye labels, yielding a very high Raman scattering intensity for each bead. To functionalise these beads for use in biological assays an outer polymer shell can be added, which allows the attachment of oligonucleotide probes. Oligonucleotide modified beads can then be used for detection of specific oligonucleotide targets. The specificity of SERRS will allow for the detection of multiple targets within a single assay.