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1.
ACS Omega ; 7(49): 45239-45252, 2022 Dec 13.
Article in English | MEDLINE | ID: mdl-36530306

ABSTRACT

Pesticide usage is one of the significant issues in modern agricultural practices; hence, monitoring pesticide content and its degradation is of utmost importance. A novel and simple one-pot deep eutectic solvent-based solvothermal method has been developed for the synthesis of FeVO4/reduced graphene oxide (FeV/RGO) nanocomposite. The band gap of FeV decreased upon anchoring with RGO. Enhanced activity in the detection and photocatalytic degradation has been achieved in the FeV/RGO nanocomposite compared to pure FeV and RGO. FeV/RGO was used to modify glassy carbon electrode (GCE), and the fabricated electrode was evaluated for its electrochemical detection of methyl parathion (MP). The amperometric technique was found to be more sensitive with a 0.001-260 µM (two linear ranges; 0.001-20 and 25-260 µM) wide linear range and low limit of detection value (0.70 nM). The practical applicability of modified GCE is more selective and sensitive to real samples like river water and green beans. Photocatalytic degradation of MP has been examined using FeV, RGO, and FeV/RGO nanocomposite. FeV/RGO managed to degrade 95% of MP under solar light in 80 min. Degradation parameters were optimized carefully to attain maximum efficiency. Degradation intermediates were identified using liquid chromatography-mass spectrometry analysis. The degradation mechanism has been studied in detail. FeV/RGO could serve as a material of choice in the field of electrochemical sensors as well as heterogeneous catalysis toward environmental remediation.

2.
ACS Comb Sci ; 22(10): 509-518, 2020 10 12.
Article in English | MEDLINE | ID: mdl-32806898

ABSTRACT

A MoS2-supported-calix[4]arene (MoS2-CA4) nanocatalyst was used for efficient synthesis of 2,4,5-trisubstituted imidazole derivatives from 1-(4-nitrophenyl)-2-(4-(trifluoromethyl)phenyl)ethane-1,2-dione, aldehydes and ammonium acetate under solvent-free conditions. Reusability of the catalyst up to five cycles without any significant loss in the yields of the product is the unique feature of this heterogeneous solid catalysis. Furthermore, the noteworthy highlights of this method are safe reaction profiles, broad substrate scope, excellent yields, economical, solvent-free, and simple workup conditions. All synthesized compounds were evaluated for their in vitro antitubercular (TB) activity against Mycobacterium tuberculosis (Mtb) H37Rv. Among the screened compounds 3c, 3d, 3f, 3m, and 3r had MIC values of 2.15, 2.78, 5.75, 1.36, and 0.75 µM, respectively, and exhibited more potency than the reference drugs pyrazinamide (MIC: 3.12 µM), ciprofloxacin (MIC: 4.73 µM), and ethambutol (7.61 µM). Besides, potent compounds (3c, 3d, 3f, 3m, and 3r) have been tested for inhibition of MabA (ß-ketoacyl-ACP reductase) enzyme and cytotoxic activity against mammalian Vero cell line. A molecular docking study was carried out on the MabA (PDB ID: 1UZN) enzyme to predict the interactions of the synthesized compounds. The results of the in vitro anti-TB activity and docking study showed that synthesized compounds have a strong anti-TB activity and can be adapted and produced more effectively as a lead compound.


Subject(s)
3-Oxoacyl-(Acyl-Carrier-Protein) Reductase/antagonists & inhibitors , Antitubercular Agents/chemical synthesis , Bacterial Proteins/antagonists & inhibitors , Calixarenes/chemistry , Disulfides/chemistry , Enzyme Inhibitors/chemical synthesis , Imidazoles/chemical synthesis , Molybdenum/chemistry , Mycobacterium tuberculosis/drug effects , Phenols/chemistry , Animals , Antitubercular Agents/pharmacology , Catalysis , Chlorocebus aethiops , Drug Evaluation, Preclinical , Enzyme Inhibitors/pharmacology , Humans , Imidazoles/pharmacology , Microbial Sensitivity Tests , Molecular Docking Simulation , Protein Binding , Small Molecule Libraries , Structure-Activity Relationship , Vero Cells/drug effects
3.
Arch Pharm (Weinheim) ; 350(3-4)2017 Apr.
Article in English | MEDLINE | ID: mdl-28326602

ABSTRACT

Acetylcholinesterase (AChE) inhibitors are currently the most widely prescribed drugs for Alzheimer's disease. The high potential of indole compounds in medicinal chemistry led us to discover a novel series of fluoroindole compounds. The synthesis and pharmacological analysis of the difluoropyrido[4,3-b]indoles 11-34 are described. Compounds 11-34 were tested for AChE inhibition activity using a rat brain homogenate. Compounds 25-29 display a promising in vitro profile with an IC50 value range of 46-51.6 nM and show significant protective effect on scopolamine-induced amnesia. The present data indicate that compounds 25-29 may represent attractive potent molecules for the treatment of Alzheimer's disease.


Subject(s)
Acetylcholinesterase/metabolism , Amnesia/drug therapy , Carbolines/pharmacology , Cholinesterase Inhibitors/pharmacology , Animals , CHO Cells , Carbolines/chemical synthesis , Carbolines/chemistry , Cells, Cultured , Cholinesterase Inhibitors/chemical synthesis , Cholinesterase Inhibitors/chemistry , Cricetulus , Dose-Response Relationship, Drug , Humans , Molecular Structure , Structure-Activity Relationship
4.
Arch Pharm (Weinheim) ; 349(7): 566-71, 2016 Jul.
Article in English | MEDLINE | ID: mdl-27231098

ABSTRACT

A series of new N-(substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides were designed, synthesized, and evaluated for their anticonvulsant activity. Most of the synthesized compounds exhibited potent anticonvulsant activities in the maximal electroshock (MES) and pentylenetetrazol (PTZ) test. The most promising compound 4c showed significant anticonvulsant activity with a protective index value of 3.58. The compounds 4a-c were also found to have encouraging anticonvulsant activity in the MES and PTZ screen when compared with the standard drugs, valproate and methaqualone. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drugs.


Subject(s)
Anticonvulsants/chemical synthesis , Anticonvulsants/therapeutic use , Quinazolines/chemical synthesis , Quinazolines/therapeutic use , Seizures/drug therapy , Animals , Dose-Response Relationship, Drug , Electroshock , Methaqualone/therapeutic use , Mice , Pentylenetetrazole , Picrotoxin/therapeutic use , Seizures/chemically induced , Structure-Activity Relationship , Valproic Acid/therapeutic use
5.
Article in English | MEDLINE | ID: mdl-26028406

ABSTRACT

A series of piperamides (PA) 8a-j were designed, synthesized and evaluated for their antimicrobial and anticonvulsant activity. Compounds 8a and 8h showed considerable antibacterial activity against B. subtilis with minimum inhibitory concentration (MIC) of 8 and 10 µg/mL, respectively. Compounds 8a and 8h showed advanced anticonvulsant activity as well as lower neurotoxicity than the reference drugs. The interaction between bovine serum albumin (BSA) and PA was investigated using fluorescence quenching and UV-vis absorption spectroscopy. Results showed that PA could strongly quinch the intrensic fluorescence of BSA through a static quencing procedure. The binding constant and number of binding sites of PA with BSA were obtained. The binding distance was calculated based on Forster non-radiative energy transfer theory.


Subject(s)
Amides/chemical synthesis , Amides/pharmacology , Anticonvulsants/chemical synthesis , Anticonvulsants/pharmacology , Piperidines/chemical synthesis , Piperidines/pharmacology , Serum Albumin, Bovine/metabolism , Amides/metabolism , Animals , Anticonvulsants/metabolism , Bacteria/drug effects , Binding Sites , Cattle , Energy Transfer , Fungi/drug effects , Microbial Sensitivity Tests , Piperidines/metabolism , Protein Binding , Spectrometry, Fluorescence , Spectrophotometry, Ultraviolet
6.
Arch Pharm (Weinheim) ; 347(5): 370-80, 2014 May.
Article in English | MEDLINE | ID: mdl-24446334

ABSTRACT

A series of novel 1'-[2-(difluoromethoxy)benzyl]-2'H,5'H-spiro[8-azabicyclo[3.2.1]octane-3,4'-imidazolidine]-2',5'-dione substituted hydantoins (5-32) were synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data. The novel molecules were screened for anticonvulsant activity in mice by maximal electroshock (MES) and subcutaneous pentylenetetrazol (ScPTZ)-induced seizure tests. The neurotoxicity was assessed using the rotarod method. Compounds 9, 10, 18, 30, and 31 exhibited anticonvulsant potency against MES seizure and in the ScPTZ model, with lesser neurotoxicity. Some title compounds showed lesser central nervous system depression compared to phenytoin.


Subject(s)
Anticonvulsants/chemical synthesis , Azabicyclo Compounds/chemical synthesis , Imidazolidines/chemical synthesis , Spiro Compounds/chemical synthesis , Animals , Anticonvulsants/chemistry , Anticonvulsants/therapeutic use , Anticonvulsants/toxicity , Azabicyclo Compounds/chemistry , Azabicyclo Compounds/therapeutic use , Azabicyclo Compounds/toxicity , Behavior, Animal/drug effects , Imidazolidines/chemistry , Imidazolidines/therapeutic use , Imidazolidines/toxicity , Male , Mice , Molecular Structure , Motor Activity/drug effects , Rotarod Performance Test , Seizures/drug therapy , Spiro Compounds/chemistry , Spiro Compounds/therapeutic use , Spiro Compounds/toxicity
7.
Arch Pharm (Weinheim) ; 346(3): 200-9, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23335463

ABSTRACT

New 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives 8-37 were synthesized and their pharmacological activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Compounds 11, 18, 31, and 32 showed significant and protective effect on seizure, when compared with the standard drug valproate. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug. From this study, it is quite apparent that there are at least three parameters for the activity of anticonvulsant drugs, that is, a lipophilic domain, a hydrophobic center, and a two-electron donor.


Subject(s)
Anticonvulsants/chemical synthesis , Drug Design , Nitriles/chemical synthesis , Spiro Compounds/chemical synthesis , Animals , Anticonvulsants/chemistry , Anticonvulsants/pharmacology , Anticonvulsants/toxicity , Dose-Response Relationship, Drug , Electroshock , Lethal Dose 50 , Mice , Molecular Structure , Neurotoxicity Syndromes/etiology , Nitriles/chemistry , Nitriles/pharmacology , Nitriles/toxicity , Seizures/drug therapy , Spiro Compounds/chemistry , Spiro Compounds/pharmacology , Spiro Compounds/toxicity , Structure-Activity Relationship
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