Duration-response association between occupational exposure and pancreatic cancer risk: meta-analysis.

BACKGROUND: Evidence is lacking on the occupational exposure time window to chemical agents related to pancreatic cancer risk. AIMS: This study performed meta-regression and meta-analysis to examine the dose-response association between occupational exposure duration to chemical agents and pancreatic cancer risk. METHODS: We searched and reviewed studies on exposure duration and pancreatic cancer in five databases (Cochrane Library, EMBASE, PubMed, ScienceDirect and Web of Science) from inception to 16 May 2022. Exposure refers to the years a worker was exposed to any chemical agent, and outcome variables were pancreatic cancer incidence and mortality. RESULTS: We identified 31 studies, including 288 389 participants. In the meta-regression, the positive dose-response association indicated pancreatic cancer risk increased slightly with every additional year of exposure duration (slope = 1.01; 95% confidence interval [CI] 1.00-1.02). Pancreatic cancer risk increased with an exposure duration of 1-10 (relative risk [RR] = 1.04; 95% CI 1.02-1.06), 11-20 (RR = 1.11; 95% CI 1.05-1.16), and 21-30 years (RR = 1.39; 95% CI 1.12-1.73). CONCLUSIONS: Pancreatic cancer risk increased as occupational exposure duration increased, with an exposure time window ranging from 1 to 30 years.

The new challenge of partial oxidation of methane over Fe2O3/NaY and Fe3O4/NaY heterogeneous catalysts.

As one of the most important gases that abundantly contribute to air pollution, methane becomes the most leading gas that challenges researchers to utilize it in more functional products such as methanol. In this study, the conversion process involved iron oxide species supported by sodium Y (NaY-Z) zeolite as the catalysts. This work highlighted the preparation of Fe2O3 and Fe3O4 modified NaY zeolite to investigate their catalytic performance on partial oxidation of methane to methanol, with trace amount of oxygen (0.5% in N2), in a batch reactor. The as-prepared catalysts were characterized using FTIR, XRD, SEM, and BET. The structure of NaY zeolite and its modified catalysts were confirmed. The pristine NaY-Z shows the highest activity followed by Fe2O3/NaY-3.52 (3.52 wt% of Fe loading) with high selectivity to formaldehyde (80%). Very high selectivity (∼100%) towards methanol was observed in the reactions on Fe2O3/NaY-1.70 and Fe3O4/NaY-2.55 catalysts, although the total amount of product was decreased. It was noticeable that Fe3O4/NaY-3.22 is an active catalyst and has good selectivity to methanol (70%).