Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) in breast milk of first-time Irish mothers: impact of the 2008 dioxin incident in Ireland.

The 2008 dioxin incident in Ireland resulted in elevated concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) in Irish pork and pork products, due to the consumption of contaminated animal feed by pigs. In order to investigate any resulting impact on the Irish population, these contaminants were measured in pooled breast milk samples from 109 first-time mothers, collected in 2010. A comparison of the results with similar data from 2002 revealed generally lower concentrations of PCDD/Fs and dioxin-like PCBs in the 2010 samples, confirming the declining trend reported by many authors. Contaminant concentration levels for both 2002 and 2010 were generally slightly lower than those reported internationally, with a mean combined PCDD/F and PCB WHO-TEQ of 9.66pgg(-1)fat, for an overall pooled sample of milk from 2010. An apparent slight increase in PCDFs was observed between 2002 and 2010 (from 2.73pg WHO-TEQ g(-1)fat to 3.21pg WHO-TEQ g(-1)fat), with the main contributory congener being 2,3,4,7,8-PentaCDF. While it cannot be totally discounted that the slight increase in 2,3,4,7,8-PentaCDF and in the overall PCDF WHO-TEQ in breast milk could be attributable to consumption of Irish pork during the 2008 incident, we consider that it is more likely that this was due to other factors, including the predominantly urban/industrial sampling locations for the 2010 samples, compared to 2002.

Regulatory recognition of indirect genotoxicity mechanisms in the European Union.

The European Union (EU) system for the regulation of chemicals includes approval systems for pharmaceuticals, pesticides and biocides, requirements for hazard classification and for risk assessment of industrial chemicals. Regulators have traditionally used the commonly accepted categorisation of chemicals into genotoxic (DNA-reactive) or non-genotoxic agents in their decision-making processes, and have generally considered that there is no threshold level for the former group. The recognition that a number of genotoxic agents operate by indirect genotoxicity mechanisms such as induction of aneuploidy, oxidative stress, inhibition of DNA synthesis or cytotoxicity presents new problems for the regulator. The dose-response relationship for a number of such agents is generally accepted to show a threshold, however, the degree of acceptance of the threshold effect differs in different EU regulatory systems. The classification system for mutagens is based primarily on intrinsic hazard rather than risk, and the classification criteria do not allow for a less stringent classification for chemicals operating by a threshold mechanism. In contrast, regulatory approval systems for plant protection products and therapeutic agents are based on a risk assessment approach, in which a demonstrated threshold effect for a genotoxic agent is likely to be an important factor in reaching a decision concerning authorisation of the product.

Global harmonisation of classification and labelling of hazardous chemicals.

The Globally Harmonised System (GHS) for classification and labelling will provide an internationally agreed system for hazard classification of chemical products and for communication of those hazards. Under the system, chemicals will be classified according to their physical (e.g. flammability), health/toxicological and environmental hazards. The toxicological endpoints used in the system are acute toxicity, irritation or corrosivity, sensitisation, carcinogenicity, mutagenicity, reproductive toxicity and chronic or repeat dose toxicity. The intended target audiences are those concerned with transport of dangerous goods, consumers, workers and emergency responders. Labels and safety data sheets (SDS) are the core tools of the GHS hazard communication system, and the harmonised labelling elements are symbols (within a pictogram), signal words and hazard statements. The GHS will use a building block approach in which application may vary according to the circumstances, type of product, and stage of life cycle, allowing selection of the elements appropriate to the needs of the various end users.