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Zh Mikrobiol Epidemiol Immunobiol ; (1): 123-7, 1978 Jan.
Article in Russian | MEDLINE | ID: mdl-343452

ABSTRACT

It was shown that purified and concentrated by the "Diaferm" method antibotulin sera from horse and cattle blood failed to differ by anaphylactogenic properties; at the same time in sensitization of the organism to protein of one animal species the use of the sera of another species provided a lesser reactogenicity of the preparation. The antigenic activity of the purified and concentrated sera from the blood or horses and cows in testing on rabbits was identical, but in response to cow alpha-globulin the animals responsed by a more intensive production of precipitins. The activity of cow and horse antibotulin serum (determined by the rate and stability of their association with the corresponding toxin) proved to be identical.


Subject(s)
Anaphylaxis/etiology , Botulinum Antitoxin , Clostridium botulinum/immunology , Animals , Antigens, Bacterial/isolation & purification , Antigens, Heterophile/isolation & purification , Botulinum Antitoxin/toxicity , Botulinum Toxins/isolation & purification , Cattle , Guinea Pigs , Horses , Mice , Species Specificity
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