Histoprognostic markers role in colorectal cancer.

Malignant tumors with digestive location are, according to the World Health Organization (WHO), a major cause of morbidity and mortality worldwide. In Romania, the constant increase of prevalence and incidence of colorectal cancer awarded it the status of priority public health problem. The study aimed to identify specific aspects of colorectal cancer histoprognosis that may be associated with a higher frequency of the disease. Data were collected from records and registers within Clinic of Medical Oncology, Emergency County Hospital, Craiova, Romania. Were analyzed and associated demographics and epidemiological data, clinical features, anatomotopographical, histopathological and immunohistochemical. The cases studied were adenocarcinomas with a balanced gender distribution and a worrying incidence for Craiova. The age group with the highest incidence was that of 55-64 years. Topographic, rectum and rectosigmoidian junction are the first two locations. More than half of the cases (55.55%) are adenocarcinomas with moderate differentiation and belong to the pT3 category, as extension of colorectal tumor degree. 32.5% of patients were identified with mutations in the K-Ras oncogenes and were found Ki67 positive immunoreacted and heterogeneity of antigen expression in tumor areas studied. Colorectal cancer recorded a worldwide steady increase in the incidence; growth trend in our country is above the European average. Dolj County faces with an increased incidence and mortality rates by this disease. To limit the disease at the population level and pre-malignant diagnosis is necessary to establish histoprognostic value and predictive of tumor markers.

Study of school fatigue on a group of teenagers studying at "dimitrie cantemir" highschool, iasi.

Purpose. Fatigue is a physiological phenomenon which is permanently present at students because of the scholar demands. Excessive demands can cause pathological fatigue phenomenon, which should be avoided. Subjects and method. The study included a group of 203 students from Dimitrie Cantemir Highschool in Iasi. The teenagers were questioned about the presence of the fatigue phenomenon. Results. Fatigue is rarely present at 62.6% of the questioned students. During the week, this phenomenon appears especially at the beginning (22.2%) or in the middle of the week (34.5%). In a few cases it appears at the end of the week, as it should. Night sleep is only of 6-7 hours (37.4%) or 7-8 hours (36.9%), which is not enough.The insufficient number of sleeping hours can be paid by day sleep, but most of the responses are "rarely" (50.7%). Active rest is represented by sport or other activities of choice. Sport is the only less attractive option - in most cases children allocate only 15-30 minutes a day for it (33.5%). They stay in front of the TV between 0.5 and 1 hour (42.9%) and of the computer between 2-3 hours (44.3%) daily. Conclusions. Children's daily schedule isn't balanced, so the risk of excessive fatigue really exists.

Considerations on implications of risk behavior in mental condition at students.

Social and family factors significantly influence somatic and psychical development of children and young people, differentiated by social gradient. Their behavior externalizes their capacities to adapt to family and social environment. It is the result of positive or negative influences of actions of factors in these environments. In adolescence, the social motivation of these behaviors is determined by their social relations (family, school, friends, entourage). By our conducted study we aimed to identify such behaviors, which, under various influences may gain risk or impact on health condition. 160 students, by random sex and aged between 11 and 18, were investigated anthropometric and physiometric were asked to respond to a complex set of questionnaires. The research has shown that subjects with reduced anthropometric and physiometric parameters (of the head) have serious school concerns, they are frequently extracurricular pursuits with a good academic situation, they meet the program of rest, have a peaceful sleep, have a balanced diet, no violent events, do not smoke or consume alcohol.

Evaluation of the psychoneurotic tendencies risk using the woodworth mathews personality inventory in non-institutionalized persons.

INTRODUCTION: Multiple factors of vulnerability may lead to development of abnormal social behaviour and to important psychiatric diseases. The psychopathological characteristics present at individual level can lead to a pattern of population groups that are subject to developing mental illness risks. MATERIAL AND METHODS: Multidisciplinary study (2009-2011) to assessing the current situation of mental health and identifying population risk groups for developing psychiatric disorders in a non-institutionalised population. We used the Woodworth Mathews Inventory (76 items) to a randomly selected sample of 1,200 men and women, residents in urban and rural areas. RESULTS: The extreme scores for emotiveness had a frequency more than triple for women, and we found a similar situation for obsessive-neurasthenic and depressive tendencies. People aging over 35 years had a double score (limit and poignancy) for depression than younger people, meanwhile correlation between age under 35 years and instability and antisocial tendencies is highly statistically significant (p<0.001), the frequency of extreme scores being almost double than in the older people. CONCLUSIONS: Female gender has a vulnerability for develop depressive and emotional disorders and age over 35 is also significant correlated with depressive tendencies. Younger people (under 35 years) are predisposed for pathological antisocial behaviour, fact revealed by the high scores for instability and antisocial tendencies. It is necessary to develop a program focused on the two risk categories to prevent the possible occurrence of psychiatric disorders.

Assessment of nutritional habits on a group of pupils from a countryside elementary school in Romania.

UNLABELLED: Food is a major contributor to healthy children and youth. The study of this factor must be complex, considering the dietary habits of the population. MATERIAL AND METHODS: 65 pupils from rural area were surveyed weekly about eating chicken, fish, fruits, bread and cereal by-products. A special attention was given to daily consumption of fruits (to those who recognize this contribution). RESULTS AND DISCUSSION: chicken appears in menus mostly 2-3 times a week (40.0%) or 4-7 times (27.7%). Fish is particularly present in menus one time (47.6%) or 2-3 times (26.2%). Fruits are provided in 75.4% cases 4-7 times a week. The dominant consumption of bread is of 4-7 times (90.8%) and of cereal by-products is of 2-3 times (58.5%) or even of 4-7 times (27.7%) a week. Self body weight is considered to be appropriate by 63.1% teenagers and in 23.1% cases they considered their body weight is too high. CONCLUSIONS: The implementation of national dietary programs can change the nutritional habits of children if they are based on a real assessment, achieved only with the help of surveys conducted by questionnaire method.

Socio-economic factors influencing the nutritional behaviour of pupils.

The purpose of the study was to evaluate the quality of morning nutrition of children in primary school, related to the residence environment and the family educational level. We included in our study 220 children in the age group 8-10, studying in urban and rural schools. They answered a 24-itemed questionnaire regarding their morning nutrition. Nutrition state, health state and school performance were evaluated. We found that 9.1% of all the children skip breakfast and midmorning snack. Most frequently they have margarine, salami, jam or cheese sandwiches and tea as breakfast. The free "milk and roll" are daily consumed by less than 45 % of the subjects. We did not find significant disorders in their nutrition and health state. Educational activities for a healthy nutrition are necessary.

Evaluation of women knowledge and attitude regarding cervical cancer early detection.

At European level, Romania unfortunately comes first as far as mortality due to cervical cancer is concerned, mortality rate recording a continuous increase due to disease detection in advanced stages. In this context, we followed an assessment of women's cognitive and attitudinal fund in relation to early detection of cervical cancer, through the application of a questionnaire on a batch of 617 women with ages from 18 to 75-year-old, with various levels of education, residents of Craiova City and communes from Dolj County. Statistic processing of their answers indicates that 43.3% of the inquired subjects have not had a routine gynecological exam for at least seven years (or even never), which is more often found in the subgroup of women from the rural environment, with ages over 35 years and with an elementary educational level (p<0.001). 65.8% of the women have not done a Babes-Papanicolau test for seven years or even never, residence area, age and education level being once again discrimination factors between the subgroups. The reasons usually put forward as a justification for the failure to do the cytological test for the past three years are negligence (23.8%), the lack of information on the existence of such an investigation (18.2%), the absence of a genital pathology (12.8%) or of a medical recommendation (11.8%). Results suggest the need to provide uniform accessibility of the population to health services, by developing and implementing new strategies of educational and sanitary intervention mainly in rural communities.

Steatosis and serum lipid patterns in patients with chronic viral hepatitis: differences related to viral etiology.

Lipid metabolism disorders related to viral etiology are described in chronic viral hepatitis, independent of age, gender and liver synthetic function. Steatosis is present, especially in chronic hepatitis C but also in chronic hepatitis B. Although liver biopsy is the gold standard in determining presence of steatosis, its presence can be determined by ultrasonographic examination as an initial screening test. Our aim in this study was to evaluate the presence of steatosis in chronic hepatitis B and C, to determine its frequency in both hepatitis type, and to explore possible relationships between presence of steatosis, lipid metabolism disorders and viral etiology. Our study lot included 66 patients, 36 subjects with chronic hepatitis C, and 30 with chronic hepatitis B. We only encountered significant levels of steatosis in the chronic hepatitis B sub-group. We found the average age, cholesterol, triglyceride, HDL-C, VLDL-C levels in the group with steatosis to be significantly higher than those in the group without steatosis (p < 0.05). Ultrasound reports of hepatic steatosis were particularly associated with histological inflammation, as well as fibrosis; however, the sensitivity and specificity of steatosis on ultrasound was poor when compared to steatosis on biopsy. Hepatic steatosis was significantly more frequent in chronic hepatitis C than in chronic hepatitis B. Severe inflammation and advanced fibrosis were more frequently found in HCV-infected patients with steatosis than in patients without steatosis.

[Smoking, alcohol consumption and pregnancy in a population of south-western Romania]. / Fumatul, consumul de alcool si sarcina la populatii din sud-vestul României.

UNLABELLED: The purpose of the study was to evaluate the amplitude of tobacco and alcohol consumption among two populations living in urban, respectively rural areas in the South-Western part of the country. The presence of the two risky behaviours during the pregnancy was also analysed. MATERIAL AND METHOD: A number of 1,200 people, men and women, aged 18-75 years, with different educational levels, living in urban and rural communities were asked to answer a questionnaire with 111 items regarding their knowledge and attitudes about the sexual-reproductive health; 11 items referred to tobacco smoking and alcohol drinking. RESULTS: About half of the subjects have never smoked. The mean age of starting smoking was 16.97 years. A number of 295 subjects (24.6%) were daily active smokers, men more frequently than women (p < 0.001). A percentage of 77.3% of the subjects used to drink alcohol, 16.4% of them daily. The daily alcohol consumption was more frequent among men, low educated people and rural inhabitants comparing to women, respectively high educated or urban inhabitants (p < 0.001); 11.2% of the respondents got frequently drunk. During the last pregnancy in the couple, women and high educated people stopped smoking and drinking more frequently then men, respectively low educated people. CONCLUSIONS: The above findings indicate the need to start in school effective health promotion campaigns to reduce tobacco and alcohol consumption and the need for support of population-based educational interventions aimed at smoking cessation in both parents.

[Aspects of children's nutritional habits in two rural communities]. / Aspecte legate de alimentatia copiilor din doua colectivitati rurale.

Food intake and nutritional habits are influenced by many factors. The survey performed in two rural communities close to Roman city, but pending of different counties, shows that there are significant differences in food intake, related to the socio-economic status. The children from Valea Ursului have a more adequate food intake and the nutritional habits are closer to the ideal behaviour, compared with the children from Bacesti.