ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare disorder mainly of children, whose pathogenesis is still unknown. Some studies have demonstrated that LCH lesions produce different cytokines abnormally that may be relevant to the pathogenesis of the disease. The purpose of this study was to investigate interleukin-1 beta (IL-1 beta) and prostaglandin E2 (PGE(2)) levels in saliva from children with different clinical subtypes of LCH. We studied 29 children with LCH: seven unifocal (Group I), seven multifocal (Group II), 15 multisystemic (Group III) and 12 healthy volunteers (Group IV). Salivary IL-1 beta and PGE(2) levels were significantly higher in LCH than in normal children. A multi-comparison test showed significantly (P < 0.001) higher levels of both IL-1 beta and PGE(2) in saliva from Group III compared with Groups II and I. A significant correlation (r = 0.05) between IL-1 beta and PGE(2) concentrations in saliva from each group was determined. Our findings demonstrated an association between high concentrations of salivary IL-1 beta and PGE(2) and advanced stages of the disease. This allows us to suggest that the abnormal amount of these factors in saliva may serve as a risk marker for disease progression.
Subject(s)
Dinoprostone/metabolism , Histiocytosis, Langerhans-Cell/metabolism , Interleukin-1beta/metabolism , Saliva/metabolism , Analysis of Variance , Biomarkers/metabolism , Case-Control Studies , Child, Preschool , Female , Histiocytosis, Langerhans-Cell/classification , Humans , Male , Reference Values , Severity of Illness IndexABSTRACT
Problemas gingivales y periodontales en niños y adolescentes, Virginia F. de Preliasco y Hugo Romanelli. Criterios quirúrgicos en odontopediatría, José Luis Ferrería
Subject(s)
Preventive Dentistry , Periodontal Diseases/surgery , Child , Surgery, Oral/methodsABSTRACT
Programa de educación continua odontologica no convencional
Subject(s)
Pediatric Dentistry , ODONTOLOGIA INTEGRAL NINOS , Periodontics , Surgery, Oral , Pediatric Dentistry , Pediatric DentistryABSTRACT
Programa de educación continua odontologica no convencional. Odontologia integral para niños II
Subject(s)
Pediatric Dentistry , ODONTOLOGIA INTEGRAL NINOS , Emergencies , Tooth Injuries , Pediatric Dentistry , Pediatric DentistryABSTRACT
Programa de educación continua odontologica no convencional
Subject(s)
ATENCION INTEGRAL NINOS , Dentistry, Operative , Mouth Rehabilitation , Pediatric Dentistry , Pediatric DentistryABSTRACT
Programa de educación continua odontologica no convencional
Subject(s)
ATENCION INTEGRAL NINOS , Oral Health , Psychology , Pediatric Dentistry , Pediatric DentistryABSTRACT
Programa de educación continua odontologica no convencional. Odontologia integral para niños II
Subject(s)
Pediatric DentistryABSTRACT
Prevención de traumatismos. Tratamiento de dientes traumatizados
Subject(s)
Tooth Injuries/prevention & control , Tooth Injuries/therapy , Tooth InjuriesABSTRACT
Prevención de traumatismos. Tratamiento de dientes traumatizados
