Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Publication year range
3.
Chemioterapia ; 6(2): 120-3, 1987 Apr.
Article in English | MEDLINE | ID: mdl-3474078

ABSTRACT

The authors evaluated the tissue levels of ofloxacin in 63 patients with urogenital diseases, in comparison to the minimum inhibitory concentrations 80% (MIC80) of some strains. The drug was administered in a single dose (300 mg) about 3 hours before surgery. After washing carefully, the tissue-levels were measured by using the HPLC method. In the normal renal parenchyma of 8 patients, the mean value was 22.10 micrograms/g of tissue; 19.23 micrograms/g in 13 patients with deranged excretory pathways; 10.62 micrograms/g in 25 patients with benign prostatic hypertrophy; 10.90 micrograms/g in 14 deferent duct patients. These results indicate that the drug is promptly distributed in various tissues of the urinary-genital apparatus at high concentrations.


Subject(s)
Anti-Bacterial Agents/metabolism , Oxazines/metabolism , Urogenital System/metabolism , Adult , Anti-Bacterial Agents/urine , Bacteria/drug effects , Female , Humans , Kidney Diseases/metabolism , Kinetics , Male , Microbial Sensitivity Tests , Middle Aged , Ofloxacin , Oxazines/urine , Prostate/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL
...