1.
ACS Chem Biol
; 13(1): 53-59, 2018 01 19.
Article
in English
| MEDLINE
| ID: mdl-29185700
ABSTRACT
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.
