1.
Lancet
; 1(8177): 1043-7, 1980 May 17.
Article
in English
| MEDLINE
| ID: mdl-6103389
ABSTRACT
30 patients with disorders of calcium metabolism were treated with dichloromethylene diphosphonate (C1(2)MDP, or clodronate disodium), an inhibitor of bone resorption. 13 patients with Paget's disease of bone were given C1(2)MDP by mouth (1.6 g/day). Serum-alkaline-phosphatase and urinary hydroxyproline fell to normal or near-normal within 3-7 months, and there was a clinical improvement in all but 1 patient. C1(2)MDP (0.8-3.2 g/day) also reduced plasma-calcium and urinary calcium in 17 patients with hypercalcaemia due to primary hyperparathyroidism or secondary to malignant disease. C1(2)MDP seems to be an effective oral drug for inhibiting excessive bone resorption in man.
Subject(s)
Clodronic Acid/therapeutic use , Diphosphonates/therapeutic use , Hypercalcemia/drug therapy , Hyperparathyroidism/complications , Neoplasms/complications , Osteitis Deformans/drug therapy , Alkaline Phosphatase/blood , Bone Resorption/drug effects , Calcium/blood , Clodronic Acid/administration & dosage , Humans , Hydroxyproline/urine , Hypercalcemia/etiology
2.
J Obstet Gynaecol Br Commonw
; 76(5): 404-11, 1969 May.
Article
in English
| MEDLINE
| ID: mdl-5769197
Subject(s)
Amino Acids/blood , Placenta/metabolism , Umbilical Arteries , Umbilical Veins , Uterus/blood supply , Analysis of Variance , Cesarean Section , Delivery, Obstetric , Female , Fetus/metabolism , Gestational Age , Histidine/blood , Humans , Infant, Newborn , Infant, Premature , Leucine/blood , Lysine/blood , Maternal-Fetal Exchange , Nitrogen/metabolism , Phenylalanine/blood , Pregnancy , Serine/blood , Tyrosine/blood
3.
J Obstet Gynaecol Br Commonw
; 76(4): 333-4, 1969 Apr.
Article
in English
| MEDLINE
| ID: mdl-5778797
4.
Clin Sci
; 35(1): 55-61, 1968 Aug.
Article
in English
| MEDLINE
| ID: mdl-5679888
5.
J Clin Endocrinol Metab
; 26(7): 781-5, 1966 Jul.
Article
in English
| MEDLINE
| ID: mdl-5917036