1.
Nucleosides Nucleotides Nucleic Acids
; 21(4-5): 335-60, 2002.
Article
in English
| MEDLINE
| ID: mdl-12182347
ABSTRACT
The syntheses of thiazinone, thiazinedione and thiazolinone base modified nucleoside analogues have been discussed in both the deoxy- and ribosyl series. Both inter- and intramolecular N-glycosylations were evaluated.
Subject(s)
Nucleosides/chemical synthesis , Thiazoles/chemical synthesis , Glycosylation , Models, Chemical
2.
Nucleosides Nucleotides Nucleic Acids
; 19(4): 735-48, 2000 Apr.
Article
in English
| MEDLINE
| ID: mdl-10960032
ABSTRACT
The synthesis of 3'-O2-(azaheterocycle)-thymidines is presented from 1-thia-3-aza- 1,3-butadiene precursors (N-thioacylamidines). A variety of heterocycles is accessible using the dienic, the electrophilic or the nucleophilic reactivity of these thia-azabutadiene systems. 3'-O2-(azaheterocycle)-thymidine analogues are regarded as potential substrates to interfere with the DNA-polymerization process.