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1.
Int J Clin Pract Suppl ; (162): 36-41, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19624798

ABSTRACT

Despite recent advances in medical treatment, pulmonary arterial hypertension (PAH) continues to be associated with high morbidity and mortality. While the diagnosis is established via a right heart catheterisation, current non-invasive measures of disease severity and response to treatment used in clinical practice are the 6-min walk distance and the World Health Organization functional class. Although both parameters correlate with disease severity and prognosis, they have significant limitations. A major shortcoming in assessing PAH is lack of standardised, non-invasive, objective parameters that function as biomarkers to help assess the severity and prognosis of disease and to follow patients' response to treatment. In this article, we will review current knowledge on potential biomarkers associated with diagnosis, prognosis and response to treatment of PAH. Most biomarkers are either being evaluated for potential use in clinical practice, or being used as research tools.


Subject(s)
Biomarkers/blood , Hypertension, Pulmonary/diagnosis , Humans , Quality of Life , Surveys and Questionnaires , Ventricular Dysfunction, Right/diagnosis
2.
Chest ; 120(3): 866-72, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11555522

ABSTRACT

OBJECTIVE: To assess short-term and long-term responses to treatment with pulmonary vasodilators in patients with sarcoidosis-related pulmonary hypertension. METHODS: A prospective, observational study was performed on eight patients with moderate-to-severe sarcoidosis-related pulmonary hypertension. Patients underwent a short-term vasodilator trial, using inhaled nitric oxide (iNO), IV epoprostenol, and/or oral calcium-channel blockers. A favorable short-term response was considered a > or = 20% decrease in pulmonary vascular resistance (PVR). Five patients received long-term treatment with iNO (with one patient receiving epoprostenol in addition) and underwent follow-up hemodynamic and/or 6-min walk testing. Two patients received long-term treatment with calcium-channel blockers. RESULTS: Baseline (+/- SE) mean pulmonary artery pressure (mPAP) was 55 +/- 4 mm Hg and PVR was 896 +/- 200 dyne.s.cm(-5). A favorable short-term response was seen in seven of eight patients receiving iNO, four of six patients receiving epoprostenol, and two of five patients receiving calcium-channel blockers. With iNO, PVR decreased 31 +/- 5% (p = 0.006) and mPAP decreased 18 +/- 4% (p = 0.003); with epoprostenol, PVR decreased 25 +/- 6% (p = 0.016) and mPAP decreased 6 +/- 2% (p = not significant). Decreased systemic vascular resistance was the only significant response to treatment with calcium-channel blockers. Follow-up 6-min walk test results improved in all five patients receiving long-term treatment with iNO. Follow-up hemodynamic responses in three patients showed preserved vasoresponsiveness. These three patients subsequently died, as did the two patients receiving calcium-channel blockers. The two remaining patients continue to receive iNO. CONCLUSION: In the short term, pulmonary hypertension in patients with sarcoidosis is responsive to treatment with pulmonary vasodilators; these patients may benefit from long-term iNO therapy.


Subject(s)
Hypertension, Pulmonary/drug therapy , Hypertension, Pulmonary/etiology , Sarcoidosis/complications , Vasodilator Agents/therapeutic use , Administration, Inhalation , Adult , Aged , Calcium Channel Blockers/therapeutic use , Epoprostenol/therapeutic use , Female , Hemodynamics/drug effects , Humans , Hypertension, Pulmonary/physiopathology , Male , Middle Aged , Nitric Oxide/therapeutic use , Platelet Aggregation Inhibitors/therapeutic use , Prospective Studies , Respiratory Function Tests , Vascular Resistance , Vasodilator Agents/pharmacology
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