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Bioorg Med Chem Lett
; 15(14): 3374-9, 2005 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-15961311
ABSTRACT
Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.