[The effect of 3-oxypyridine and succinic acid derivatives on obsessive-compulsive activity of mice in marble-burying test].

The effect of domestic derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin, and mexidol) on obsessive-compulsive behavior of mice was studied in the marble-burying test. Additionally the effect of these drugs on the behavior of animals was assessed in the open field test. Amitriptylin and alpha-lipoic acid were used as reference drugs. It was established that single administration of the investigated drugs in optimal doses, corresponding to therapeutic range in humans, inhibits obsessive-compulsive behavior of mice in the marble-burying test. Amitriptylin and alpha-lipoic acid produced similar effects. It is established that emoxipine stimulates the behavior of mice in the open field after single administration. An increase in the emoxipine dose led to decrease of stimulation and gradual development of sedative effect. Reamberin and mexidol, as well as alpha-lipoic acid and amitriptyline, caused sedation in mice tested in the open field. Inhibiting effect of emoxipine, reamberin, mexidol and alpha-lipoic acid on the obsessive-compulsive behavior in mice directly depended on sedative action of these drugs.

[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in the acute phase of alloxan-induced diabetes in rats].

The effect of derivatives of 3-oxypyridine and succinic acid (emoxypine, reamberin, and mexidol) on the manifestations of anxiety (according to the criteria of behavior in elevated cross plus maze test) depression (according to the criterian of immobility in the Porsolt test) in the acute phase of alloxan diabetes (96 h after alloxan administration) has been studied in rats. The effectiveness of emoxypine, reamberin, and mexidol was compared with that of alpha-lipoic acid (etalon treatment of diabetic neuropathy). It was established that a single administration of 3-oxypyridine and succinic acid derivatives in doses equivalent to the therapeutic range for humans corrected anxio-depressive disorders in the acute phase of alloxan diabetes, while being not inferior to alpha-lipoic acid with respect to the intensity of anxiolytic and antidepressant action. The correction of affective disorders by emoxypine, reamberin and mexidol did not depend on their effect on hyperglycemia in the acute phase of alloxan diabetes. The most pronounced anxiolytic action was observed upon the administration of emoxypine, while the most pronounced antidepressant effect was observed upon the administration of mexidol.

[Protective effect of 3-oxypyridine and succinic acid derivatives under conditions of acute alloxan-induced intoxication in mice].

Protective action of 3-oxypiridine and succinic acid derivatives (emoxipin, reamberin and mexidol) was studied in mice under acute alloxan-induced intoxication conditions. All these drugs exhibited protective action with respect to hyperglycemia and hyperglycemia-connected elongation of desperate behavior in the tail-suspension test and reduced activity level on the open field test. Mexidol exceeded emoxipin in the dose range of protecting action with respect to alloxan-induced hyperglycemia and was superior to reamberin in the treatment of desperate behavior in the tail-suspension test.

[The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia].

OBJECTIVE: The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models. MATERIAL AND METHODS: We used 260 adult outbred mice. The drugs were introduced intraperitoneally 30 min before the modeling of acute brain ischemia. Each drug was used in 3 three doses: 1/2 of the calculated equivalent of mean treatment dose (EMTD), EMTD and double EMTD. A strangulation model with the assessment of mouse mortality latency and decapitation model with the assessment of agonal respiration (gasping) were used. The efficacy of the drugs was determined by comparison against alpha-lipoic acid that was used as a reference substance in previous studies of antihypoxic activity of emoxipine, reamberin and mexidol. RESULTS AND CONCLUSION: It was established that the derivatives of 3-oxipiridine and succinic acid protected against subtotal ischemia of rostral brain segments (of cerebral hemispheres) as evidenced by the increase in longevity. Emoxipine demonstrated the maximal effect thereby surpassing reamberin and mexidol in the intensity of antiischemic activity. Antiischemic effect of alpha-lipoic acid was comparable to emoxipine. In the model of total brain ischemia, the derivatives of 3-oxipiridine and succinic acid caused the opposite (proischemic) action on the bulbar respiratory center as evidenced by the reduction in duration of gasping. Alpha-lipoic acid did not affect the duration of gasping.