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1.
Burns ; 48(6): 1488-1496, 2022 09.
Article in English | MEDLINE | ID: mdl-34903404

ABSTRACT

Implementation science is a useful tool to consider ways in which we can introduce improvements to burn services in low-and-middle income countries (LMICs), where the majority of the burden of burn injury is now experienced. This paper outlines the development of the Delivery Assessment Tool (DAT), a method for facilitating quality improvement in burn services in LMICs. We used a participatory approach that ensured that local clinicians and experts were fully involved in piloting the tool. The DAT is based on internationally agreed operational standards for burn care service delivery and has undergone an iterative process of improvement and refinement through an initial three-year project in Nepal and Bangladesh. The DAT, a 50-item tool organised into 10 subsections, is used to assess a service through a participatory focus group discussion with a mixed, multidisciplinary team of staff working at the burn service, typically 6-10 participants. This usually lasts 2-3 h. The staff in the unit then select priority areas for quality improvement programmes that are within their control to achieve, which starts a cycle of audit and review. The final version of the tool was used in a further three-year project to evaluate 11 hospitals in Nepal and Bangladesh. Education and training are key components of this work; both were provided by Interburns as part of on-going support for the clinical teams. At the end of the project a>19% improvement in scores was demonstrated using the final version of the DAT in both Nepal and Bangladesh; this achievement is remarkable given the continued difficulties in service provision where patient numbers far outstrip the resources available to care for them. As a result of this work, we have made a digital version of the tool available free of charge.


Subject(s)
Burns , Developing Countries , Burns/therapy , Delivery of Health Care , Humans , Poverty , Quality Improvement
2.
Burns ; 46(8): 1756-1767, 2020 12.
Article in English | MEDLINE | ID: mdl-32616426

ABSTRACT

Consistent evidence has emerged over many years that the mortality and morbidity outcomes for burn patients in low and middle-income countries (LMICs) lag behind those in more resource rich countries. Interburns is a charity that was set up with the aim of working to reduce the disparity in the number of cases of burns as well as the outcomes for patients in LMICs. This paper provides an overview of a cyclical framework for quality improvement in burn care for use in LMICs that has been developed using an iterative process over the last 10 years. Each phase of the process is outlined together with a description of the tools used to conduct a gap analysis within the service, which is then used to frame a programme of capacity enhancement. Recent externally reviewed projects have demonstrated sustained improvement with the use of this comprehensive and integrated approach over a three-year cycle. This overview paper will be supported by further publications that present these results in detail.


Subject(s)
Burns/therapy , Capacity Building/methods , Quality Improvement , Burn Units/economics , Burn Units/trends , Burns/economics , Developing Countries/statistics & numerical data , Humans , Nepal , Resource Allocation/methods
4.
Diabetes Metab Res Rev ; 32 Suppl 1: 84-98, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26340966

ABSTRACT

BACKGROUND: Prevention of foot ulcers in patients with diabetes is extremely important to help reduce the enormous burden of foot ulceration on both patient and health resources. A comprehensive analysis of reported interventions is not currently available, but is needed to better inform caregivers about effective prevention. The aim of this systematic review is to investigate the effectiveness of interventions to prevent first and recurrent foot ulcers in persons with diabetes who are at risk for ulceration. METHODS: The available medical scientific literature in PubMed, EMBASE, CINAHL and the Cochrane database was searched for original research studies on preventative interventions. Both controlled and non-controlled studies were selected. Data from controlled studies were assessed for methodological quality by two independent reviewers. RESULTS: From the identified records, a total of 30 controlled studies (of which 19 RCTs) and another 44 non-controlled studies were assessed and described. Few controlled studies, of generally low to moderate quality, were identified on the prevention of a first foot ulcer. For the prevention of recurrent plantar foot ulcers, multiple RCTs with low risk of bias show the benefit for the use of daily foot skin temperature measurements and consequent preventative actions, as well as for therapeutic footwear that demonstrates to relieve plantar pressure and that is worn by the patient. To prevent recurrence, some evidence exists for integrated foot care when it includes a combination of professional foot treatment, therapeutic footwear and patient education; for just a single session of patient education, no evidence exists. Surgical interventions can be effective in selected patients, but the evidence base is small. CONCLUSION: The evidence base to support the use of specific self-management and footwear interventions for the prevention of recurrent plantar foot ulcers is quite strong, but is small for the use of other, sometimes widely applied, interventions and is practically nonexistent for the prevention of a first foot ulcer and non-plantar foot ulcer.


Subject(s)
Diabetes Mellitus, Type 1/therapy , Diabetes Mellitus, Type 2/therapy , Diabetic Foot/prevention & control , Evidence-Based Medicine , Precision Medicine , Combined Modality Therapy/trends , Cost of Illness , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Diabetic Foot/epidemiology , Diabetic Foot/etiology , Diabetic Foot/therapy , Humans , Patient Compliance , Patient Education as Topic , Recurrence , Risk Factors , Self Care/trends , Shoes/adverse effects
6.
Diabetes Metab Res Rev ; 32 Suppl 1: 154-68, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26344936

ABSTRACT

The outcome of management of diabetic foot ulcers remains a challenge, and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012, the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing published systematic reviews of the evidence to inform protocols for routine care and to highlight areas, which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between June 2010 and June 2014. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae or hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; oxygen and other gases, compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound and other systemic therapies, which did not fit in the aforementioned categories. Heterogeneity of studies prevented pooled analysis of results. Of the 2161 papers identified, 30 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic reviews, and the conclusion is similar: that with the possible exception of negative pressure wound therapy in post-operative wounds, there is little published evidence to justify the use of newer therapies. Analysis of the evidence continues to present difficulties in this field as controlled studies remain few and the majority continue to be of poor methodological quality.


Subject(s)
Anti-Infective Agents/therapeutic use , Diabetic Foot/therapy , Evidence-Based Medicine , Precision Medicine , Skin Diseases, Infectious/drug therapy , Soft Tissue Infections/drug therapy , Wound Healing , Anti-Infective Agents/adverse effects , Anti-Infective Agents, Local/adverse effects , Anti-Infective Agents, Local/therapeutic use , Biological Therapy/adverse effects , Biological Therapy/trends , Combined Modality Therapy/adverse effects , Combined Modality Therapy/trends , Debridement/adverse effects , Debridement/trends , Diabetic Foot/complications , Diabetic Foot/microbiology , Diabetic Foot/rehabilitation , Drug Therapy, Combination/adverse effects , Humans , Hyperbaric Oxygenation/adverse effects , Hyperbaric Oxygenation/trends , Limb Salvage/adverse effects , Limb Salvage/trends , Skin Diseases, Infectious/complications , Skin Diseases, Infectious/microbiology , Skin Diseases, Infectious/therapy , Skin Transplantation/adverse effects , Skin Transplantation/trends , Soft Tissue Infections/complications , Soft Tissue Infections/microbiology , Soft Tissue Infections/therapy , Therapies, Investigational/adverse effects , Therapies, Investigational/trends , Wound Healing/drug effects
7.
Diabetes Metab Res Rev ; 28 Suppl 1: 119-41, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22271737

ABSTRACT

The outcome of management of diabetic foot ulcers is poor, and there is continuing uncertainty concerning optimal approaches to management. It was for these reasons that in 2006 the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing undertook a systematic review of the evidence to inform protocols for routine care and to highlight areas which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between December 2006 and June 2010. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae and hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; hyperbaric oxygen therapy (HBOT); compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound; other systemic therapies which did not fit in the above categories. Heterogeneity of studies prevented pooled analysis of results. Of the 1322 papers identified, 43 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic review, but the conclusion is similar: that with the exception of HBOT and, possibly, negative pressure wound therapy, there is little published evidence to justify the use of newer therapies. This echoes the conclusion of a recent Cochrane review and the systematic review undertaken by the National Institute for Health and Clinical Excellence Guidelines Committee in the UK. Analysis of evidence presents considerable difficulties in this field particularly as controlled studies are few and the majority are of poor methodological quality.


Subject(s)
Diabetes Mellitus/physiopathology , Diabetic Foot/therapy , Wound Healing , Chronic Disease , Diabetes Complications/etiology , Humans
9.
Eur J Clin Microbiol Infect Dis ; 31(9): 2183-9, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22278295

ABSTRACT

Chronic non-healing wounds are a major health problem with resident bacteria strongly implicated in their impaired healing. A rapid-screen to provide detailed knowledge of wound bacterial populations would therefore be of value and help prevent unnecessary and indiscriminate use of antibiotics-a process associated with promoting antibiotic resistance. We analysed chronic wound fluid samples, which had been assessed for microbial content, using 20 different fluorescent labelled peptide substrates to determine whether protease activity correlated with the bacterial load. Eight of the peptide substrates showed significant release of fluorescence after reaction with some of the wound samples. Comparison of wound fluid protease activities with the microbiological data indicated that there was no correlation between bacterial counts and enzyme activity for most of the substrates tested. However, two of the peptide substrates produced a signal corresponding with the microbial data revealing a strong positive correlation with Pseudomonas aeruginosa numbers. This demonstrated that short fluorescent labelled peptides can be used to detect protease activity in chronic wound fluid samples. The finding that two peptides were specific indicators for the presence of P. aeruginosa may be the basis for a diagnostic test to determine wound colonisation by this organism.


Subject(s)
Bacterial Load , Peptide Hydrolases/analysis , Pseudomonas Infections/microbiology , Pseudomonas aeruginosa/enzymology , Wound Infection/microbiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Chronic Disease , Female , Humans , Infant , Male , Middle Aged , Pseudomonas Infections/pathology , Wound Infection/pathology , Young Adult
10.
Health Technol Assess ; 13(54): 1-86, iii-iv, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19922726

ABSTRACT

OBJECTIVES: To determine the comparative effectiveness and cost-effectiveness of three dressing products, N-A, Inadine and Aquacel, for patients with diabetic foot ulcers, as well as the feasibility and consequences of less frequent dressing changes by health-care professionals. DESIGN: A multicentre, prospective, observer-blinded, parallel group, randomised controlled trial, with three arms. SETTING: Established expert multidisciplinary clinics for the management of diabetic foot ulcers across the UK. PARTICIPANTS: Patients over age 18 with type 1 or type 2 diabetes with a chronic (present for at least 6 weeks) full-thickness foot ulcer (on or below the malleoli) not penetrating to tendon, periosteum or bone, and with a cross-sectional area between 25 and 2500 mm(2). INTERVENTIONS: Participants were randomised 1:1:1 to treatment with one of N-A (a non-adherent, knitted, viscose filament gauze), Inadine (an iodine-impregnated dressing), both traditional dressings, or Aquacel, a newer product. MAIN OUTCOME MEASURES: The primary outcome measure was the number of ulcers healed in each group at week 24. Secondary measures included time to healing, new ulcerations, major and minor amputations, and episodes of secondary infection. RESULTS: A total of 317 patients were randomised. After 88 withdrawals, 229 remained evaluable. A greater proportion of smaller (25-100 mm(2) ulcers healed within the specified time (48.3% versus 37.3%; p = 0.048). There was, however, no difference between the three dressings in terms of percentage healed by 24 weeks, or in the mean time to healing, whether analysed on the basis of intention to treat (Inadine 44.4%, N-A 38.7%, Aquacel 44.7%; not significant) or per protocol (Inadine 55.2%, N-A 59.4%, Aquacel 63.0%; not significant). There was no difference in the quality of healing, as reflected in the incidence of recurrence within 12 weeks. Likewise, there was no difference in the incidence of adverse events, although a greater proportion of those randomised to the non-adherent dressings were withdrawn from the study (34.9% versus 29.1% Aquacel and 19.4% Inadine; p = 0.038). The only statistically significant difference found in the health economic analysis was the cost associated with the provision of dressings (mean cost per patient: N-A 14.85 pounds, Inadine 17.48 pounds, Aquacel 43.60 pounds). The higher cost of Aquacel was not offset by the fewer dressings required. There was no difference in measures of either generic or condition-specific measures of quality of life. However, there was a significant difference in the change in pain associated with dressing changes between the first and second visits, with least pain reported by those receiving non-adherent dressings (p = 0.012). There was no difference in the costs of professional time, and this may relate to the number of dressing changes undertaken by non-professionals. Fifty-one per cent of all participants had at least one dressing change undertaken by themselves or a non-professional carer, although this ranged from 22% to 82% between the different centres. CONCLUSIONS: As there was no difference in effectiveness, there is no reason why the least costly of the three dressings could not be used more widely across the UK National Health Service, thus generating potentially substantial savings. The option of involving patients and non-professional carers in changing dressings needs to be assessed more formally and could be associated with further significant reductions in health-care costs. TRIAL REGISTRATION: Current Controlled Trials ISRCTN78366977.


Subject(s)
Bandages , Diabetic Foot/complications , Foot Ulcer/therapy , Aged , Bandages/economics , Diabetic Foot/drug therapy , Female , Humans , Male , Middle Aged , Treatment Outcome , United Kingdom , Wound Healing
11.
Int Wound J ; 6(4): 267-74, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19719523

ABSTRACT

This study investigated the number and type of chronic wounds actually treated by Dutch nursing home physicians (NHPs). It was also the goal to know how many of the treated chronic wounds they considered infected. The NHPs were asked to choose and rank their top five out of several provided criteria for chronic wound infection. After this, the ranking was compared with the choices an international multidisciplinary Delphi group of wound experts made in 2005. A cross-sectional descriptive survey was conducted using the information from a self-reported questionnaire in a representative sample of Dutch NHPs. About 361 NHPs (25%) were sent a questionnaire. Of the 361 physicians, 139 (38.5%) filled in and returned the questionnaire of which 121 were valid. Of the NHPs, 73.5% actually treated at least one chronic pressure ulcers (PU), whereas 26.5% did not treat any. Of the responding NHPs,31.6 % treated at least one, but never more than two chronic post surgical wounds , whereas 68.4% of the NHPs treated none [corrected]. Chronic venous leg ulcers, arterial ulcers and diabetic ulcers scored infrequently and less than the other two sorts of chronic wounds. Of the Dutch NHPs, 53% considered that none of the PU infected. The other chronic wounds were judged far less frequently to be infected. Dutch NHPs appeared to use more 'traditional' criteria such as 'puss/abscess' and 'malodour' to identify infection and did not change their criteria by wound type. According to this study, NHPs do not frequently see many chronic wounds. The most frequent type of wounds treated was PU. For NHPs, the identification of infection of all types of chronic wounds is difficult. The use of criteria that is not in line with consensus documents may lead to ineffective treatment and even seriously damage patients: the clinical identification of infection is still dependent on experts' opinion. Further research on triggers for the suspicion of wound infection and the development of an evidence-based guideline is necessary.


Subject(s)
Physicians , Severity of Illness Index , Wound Infection/diagnosis , Cross-Sectional Studies , Data Collection , Humans , Netherlands/epidemiology , Nursing Homes , Pressure Ulcer/complications , Pressure Ulcer/epidemiology , Prevalence , Professional Competence , Wound Infection/epidemiology
12.
Clin Biomech (Bristol, Avon) ; 23(9): 1183-91, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18644661

ABSTRACT

BACKGROUND: Diabetic peripheral neuropathy is known to cause postural instability. This study investigated standing balance in patients with diabetic neuropathy with secondary foot complications: foot ulceration, partial foot amputation and trans-tibial amputation, which are expected to pose further challenge to balance control. METHODS: In this cross-sectional study, 23 patients with diabetic neuropathy alone (controls) were compared with 23 patients with diabetic foot ulceration, 16 patients with partial foot amputation and 22 patients with trans-tibial amputation. Posturography was used to determine the centre of pressure excursion during quiet standing. Differences between the 4 groups were tested using ANOVA and post-hoc comparisons. FINDINGS: The 4 groups varied in neuropathy score (P=0.001) and demonstrated significant decline in balance from neuropathy alone to foot ulceration, to partial foot amputation and trans-tibial amputation based on total excursion of centre of pressure (P<0.001) and centre of pressure excursion in antero-posterior direction (P<0.001). The excursion of centre of pressure in medio-lateral direction varied between 4 groups (P<0.05) however, there was no significant trend. The distance between ankles increased significantly from neuropathy to trans-tibial amputee group (P=0.001). Post-hoc comparison with controls revealed that each of three study groups demonstrated decreased balance (diabetic neuropathy vs. foot ulceration, P=0.001, diabetic neuropathy vs. partial foot amputation, P=0.002 and diabetic neuropathy vs. trans-tibial amputation, P=0.009). INTERPRETATION: Balance deterioration among patient groups from diabetic neuropathy alone to trans-tibial amputation appears to result from bio-mechanical impairment caused by progression of foot complications in addition to postural instability caused by diabetic neuropathy.


Subject(s)
Diabetic Foot/physiopathology , Foot/physiopathology , Muscle, Skeletal/physiopathology , Postural Balance , Posture , Adult , Aged , Disease Progression , Female , Humans , Male , Middle Aged , Motion , Muscle Contraction , Pressure
13.
Diabetes Metab Res Rev ; 24 Suppl 1: S119-44, 2008.
Article in English | MEDLINE | ID: mdl-18442185

ABSTRACT

The outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness. A search was made for reports of the effectiveness of interventions assessed in terms of healing, ulcer area or amputation in controlled clinical studies published prior to December 2006. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network (SIGN) criteria. Selected studies fell into the following categories: sharp debridement and larvae; antiseptics and dressings; chronic wound resection; hyperbaric oxygen (HBO); reduction of tissue oedema; skin grafts; electrical and magnetic stimulation and ultrasound. Heterogeneity of studies prevented pooled analysis of results. Of the 2251 papers identified, 60 were selected for grading following full text review. Some evidence was found to support hydrogels as desloughing agents and to suggest that a systemic (HBO) therapy may be effective. Topical negative pressure (TNP) may promote healing of post-operative wounds, and resection of neuropathic plantar ulcers may be beneficial. More information was needed to confirm the effectiveness and cost-effectiveness of these and other interventions. No data were found to justify the use of any other topically applied product or dressing, including those with antiseptic properties. Further evidence to substantiate the effect of interventions designed to enhance the healing of chronic ulcers is urgently needed. Until such evidence is available from robust trials, there is limited justification for the use of more expensive treatments and dressings.


Subject(s)
Diabetic Foot/therapy , Foot Ulcer/therapy , Wound Healing , Anti-Infective Agents/therapeutic use , Bandages , Chronic Disease , Debridement , Diabetic Foot/drug therapy , Diabetic Foot/surgery , Edema/prevention & control , Foot Ulcer/drug therapy , Foot Ulcer/surgery , Granulocyte Colony-Stimulating Factor/therapeutic use , Humans , Hyperbaric Oxygenation , Skin Transplantation , Treatment Outcome
15.
Surgeon ; 6(1): 26-31, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18318085

ABSTRACT

UNLABELLED: Crohn's disease (CD) demonstrates great heterogeneity in its presentation and severity. Management of CD is similarly diverse but the aim remains the same--remission of disease activity and improvement of health related quality of life (HR-QoL). Treatment options include steroids, 5-ASA derivatives, immunomodulators and surgery. The aim of this study was to define the variation in practice of consultant gastroenterologists and colorectal surgeons treating CD in Wales. METHODS: Consultant gastroenterologists and colorectal surgeons treating CD in Wales were sent a questionnaire aimed at determining their current practice and their responses were analysed. RESULTS: Eighty-eight consultants--46 (52%) gastroenterologists and 42 (48%) surgeons-- were invited to participate in the survey. Sixty-one (69%) of them responded. Coherent practice was seen across Wales, especially with respect to diagnosis of CD in line with British Society of Gastroenterology guidelines. Variation was detected in disease severity assessment and some aspects of management. CONCLUSION: Practice in Wales is in line with the guidelines for managing CD. While the diagnostic process follows a standard approach, variations exist in treatment and monitoring of disease. Validated disease measurement instruments are seldom used in routine practice. Disease assessment tools need to be simpler to use if they are to help objective measurement of disease activity and treatment decisions.


Subject(s)
Crohn Disease/therapy , Practice Patterns, Physicians' , Anti-Inflammatory Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Attitude of Health Personnel , Colorectal Surgery , Crohn Disease/classification , Crohn Disease/diagnosis , Crohn Disease/surgery , Cross-Sectional Studies , Gastroenterology , Glucocorticoids/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Mesalamine/therapeutic use , Patient Care Planning , Practice Guidelines as Topic , Prednisolone/therapeutic use , Severity of Illness Index , Surveys and Questionnaires , Wales
16.
Diabetes Metab Res Rev ; 24 Suppl 1: S101-5, 2008.
Article in English | MEDLINE | ID: mdl-18351625

ABSTRACT

Those working with patients with diabetic foot wounds are well aware that individuals who take a considerable time to heal pose ongoing challenges for health care professionals and informal carers; cycles of breakdown, recurrent infections, pain management, and adherence to treatment all require regular reassessment, renegotiation of care goals, and review of care plans. Those patients with ulcers for many years are clearly hard-to-heal and often reach a state where the wound is 'static'-not always with any apparent reason. Whilst such scenarios lead professionals to feel exasperated by the lack of progress-how often do we fully consider what this must be like from the patient's point of view? This article will focus on aspects of educational research and health psychology that can lead to a clearer understanding of ways in which professionals can negotiate with patients and empower them to take more responsibility for their own health, within a framework that clearly distinguishes between 'compliance', 'adherence', and 'concordance'. Motivation is fundamental to adherence; the key to developing individual motivation is personal self-awareness and knowledge. However, education on its own will not lead to behaviour change. Readiness to change, confidence in having the necessary skills and family support are key factors when structuring behavioural change programmes.


Subject(s)
Diabetic Foot/psychology , Patient Compliance , Patient Education as Topic , Diabetic Foot/rehabilitation , Humans , Motivation , Perception
17.
Diabet Med ; 24(10): 1105-11, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17593240

ABSTRACT

AIMS: Diabetic foot disease is associated with both macro- and microvascular disease. Exercise has both positive and negative effects on the perfusion of lower limbs with peripheral arterial occlusive disease (PAOD). We aimed to measure changes in foot perfusion following a brief period of lower-limb exercise in individuals with and without Type 2 diabetes and non-critical PAOD. METHODS: Subjects were allocated to groups according to the presence or absence of diabetes, PAOD on colour duplex imaging and clinically detectable peripheral neuropaIthy. Transcutaneous oxygen tension (TcPO(2)), transcutaneous carbon dioxide tension (TcPCO(2)), ankle-brachial pressure indices, toe pressures and toe-brachial pressure indices (TBI) were measured. RESULTS: One hundred and sixteen limbs were studied in 61 subjects. Post-exercise, toe pressure and TBI increased in the non-diabetic group with arterial disease, but not in the groups with diabetes. Foot TcPO(2) values increased in groups with diabetes and TcPCO(2) decreased in all groups with arterial disease. Increased chest TcPO(2) and decreased TcPCO(2) were demonstrated in the groups with diabetes. CONCLUSIONS: Elevations in foot TcPO(2) and reductions in TcPCO(2) indicate improved cutaneous perfusion response to local heating post-exercise. Elevated toe pressures in the non-diabetes group suggest that improved perfusion may be associated with enhanced lower limb macrovascular haemodynamics. However, improvements in TcPO(2) and TcPCO(2) at foot and chest sites in diabetes imply a global change in cutaneous perfusion. The results suggest that brief exercise results in an improvement in cutaneous perfusion in non-critical PAOD, particularly in individuals with diabetes.


Subject(s)
Diabetes Mellitus, Type 2/complications , Diabetic Foot/metabolism , Foot/blood supply , Diabetes Mellitus, Type 2/metabolism , Diabetes Mellitus, Type 2/physiopathology , Diabetic Foot/physiopathology , Exercise/physiology , Female , Humans , Male , Microcirculation , Treatment Outcome
18.
Colorectal Dis ; 9(8): 678-85, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17509051

ABSTRACT

BACKGROUND: The aims of treatments for Crohn's disease are symptom control by medical or surgical means and improvement in health-related quality of life (HRQOL). A wide number of classification systems, instruments of disease activity measurement (DAM) and HRQOL are available, but few are used in routine surgical practice. OBJECTIVE: To review the validity of DAM and HRQOL instruments and their applicability to surgically treated patients. METHOD: A systematic literature search was undertaken to identify these instruments. Qualifying articles were used to determine the construct, content and criterion validity of the instruments identified with respect to surgically treated patients. RESULTS: Thirteen disease activity indices and 11 HRQOL assessment tools were identified. Construct validity was demonstrated throughout but concerns of content and criterion validity were noted. CONCLUSION: None of the current disease activity or HRQOL tools can be used without potential bias in a trial of surgical vs medical therapy as the items included favour the outcomes experienced following medical therapy. A more balanced assessment tool in the setting of a multidisciplinary trial is needed.


Subject(s)
Crohn Disease/surgery , Crohn Disease/physiopathology , Humans , Quality of Life , Severity of Illness Index
19.
J Wound Care ; 16(2): 49-53, 2007 Feb.
Article in English | MEDLINE | ID: mdl-17319616

ABSTRACT

OBJECTIVE: To discover the impact of topical negative pressure (TNP) on quality of life. METHOD: An exploratory prospective cohort study was conducted on 26 patients undergoing TNP. The Cardiff Wound Impact Schedule (CWIS), a wound-specific tool, was used to investigate quality-of-life scores before therapy and four weeks after therapy or at wound closure. Wound dimensions were measured at both assessments, and the values for the CWIS domains (physical symptoms, social functioning, well-being and overall quality of life) were investigated using parametric and non-parametric tests. RESULTS: The mean duration of TNP therapy was 3.3 +/- 1.7 weeks. Topical negative pressure therapy helped to achieve complete wound closure in 14 patients (54%), and there was a mean reduction in wound surface area from 52.2 cm2 (range 4-150) to 26.8 cm2 (0-120). While there was no significant change in quality of life in patients whose wounds healed (1 +/- 11.9), the physical-functioning domain improved in obese patients (20 +/- 21, p < 0.05) and worsened in ambulatory patients (-3 +/- 13, p < 0.05). The portableTNP system had no significant impact on quality of life (-3 +/- 16), while the global quality-of-life score worsened with surgical intervention (-0.5 +/- 2, p < 0.05). CONCLUSION: Although TNP aids wound closure in patients with complex wounds, in selected cases their quality of life can worsen. This is the first exploratory cohort study of its kind, and has identified an urgent need to validate the use of patient-based outcome measures in TNP therapy. Such data can be useful in allocating resources and justifying funding in wound care.


Subject(s)
Attitude to Health , Quality of Life/psychology , Skin Care/psychology , Suction/psychology , Wounds and Injuries/psychology , Activities of Daily Living , Adolescent , Adult , Aged , Aged, 80 and over , Female , Health Status , Humans , Male , Mental Health , Middle Aged , Nursing Assessment , Nursing Methodology Research , Outcome Assessment, Health Care , Prospective Studies , Sickness Impact Profile , Skin Care/methods , Skin Care/nursing , Suction/adverse effects , Suction/nursing , Surveys and Questionnaires , Time Factors , Wound Healing , Wounds and Injuries/nursing , Wounds and Injuries/pathology
20.
J Antimicrob Chemother ; 55(2): 143-9, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15649989

ABSTRACT

Chronic leg and foot wounds represent an increasing burden to healthcare systems as the age of the population increases. The deep dermal tissues of all chronic wounds harbour microorganisms, however, the precise interaction between microbes in the wounds and impaired healing is unknown. With regard to antibiotic therapy, there is a lack of evidence concerning its effectiveness, optimal regimens or clinical indications for treatment. Despite this lack of evidence, antibiotics are frequently a feature of the management of chronic wounds and these patients receive significantly more antibiotic prescriptions (both systemic and topical) than age and sex-matched patients. Current guidelines for antibiotic prescribing for such wounds are often based on expert opinion rather than scientific fact and may present difficulties in interpretation and implementation to the clinician. Although the increasing prevalence of antibiotic resistance is widely recognized, the relationships between antibiotic resistance, chronic wound microbiology and rationales for antibiotic therapy have yet to be determined. This review discusses the role of microbes in chronic wounds from a clinical perspective with particular focus on the occurrence of bacteria and their impact on such wounds. The evidence and role of antibiotics in the treatment of such wounds are outlined and current practice of antibiotic usage for chronic wounds in the primary care setting described. The implications of antibiotic usage with regard to antibiotic resistance are also considered.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Drug Resistance, Bacterial/drug effects , Practice Guidelines as Topic , Wounds and Injuries/drug therapy , Wounds and Injuries/microbiology , Animals , Anti-Bacterial Agents/pharmacology , Chronic Disease , Drug Resistance, Bacterial/physiology , Humans , Wound Healing/drug effects , Wound Healing/physiology
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