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Biochem Biophys Res Commun ; 457(4): 669-75, 2015 Feb 20.
Article in English | MEDLINE | ID: mdl-25615820

ABSTRACT

Our previous studies have shown that the liver from Naked Mole Rats (NMRs), a long-lived rodent, has increased proteasome activity and lower levels of protein ubiquitination compared to mice. This suggests that protein quality control might play a role in assuring species longevity. To determine whether enhanced proteostasis is a common mechanism in the evolution of other long-lived species, here we evaluated the major players in protein quality control including autophagy, proteasome activity, and heat shock proteins (HSPs), using skin fibroblasts from three phylogenetically-distinct pairs of short- and long-lived mammals: rodents, marsupials, and bats. Our results indicate that in all cases, macroautophagy was significantly enhanced in the longer-lived species, both at basal level and after induction by serum starvation. Similarly, basal levels of most HSPs were elevated in all the longer-lived species. Proteasome activity was found to be increased in the long-lived rodent and marsupial but not in bats. These observations suggest that long-lived species may have superior mechanisms to ensure protein quality, and support the idea that protein homeostasis might play an important role in promoting longevity.


Subject(s)
Autophagy , Heat-Shock Response , Longevity , Proteasome Endopeptidase Complex/metabolism , Animals , Biological Evolution , Cells, Cultured , Chiroptera , Fibroblasts/metabolism , Marsupialia , Mice , Mole Rats , Oxidative Stress , Phylogeny , Proteolysis , Ubiquitination
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