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J Clin Microbiol ; 46(4): 1517-9, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18272717

ABSTRACT

The new Abbott RealTime hepatitis B virus (HBV) assay was compared to the Cobas AmpliPrep/Cobas TaqMan assay with 128 serum samples from patients with chronic hepatitis B. There was an excellent correlation (r = 0.961) between the two assays, with the Abbott RealTime test showing at least equivalent sensitivity and a slightly wider dynamic range than the Cobas TaqMan assay. By coupling high sensitivity with a large dynamic range, the Abbott RealTime HBV assay is useful in monitoring the response to antiviral therapy.


Subject(s)
DNA, Viral/blood , Hepatitis B virus/isolation & purification , Hepatitis B, Chronic/virology , Polymerase Chain Reaction/methods , Reagent Kits, Diagnostic , Humans , Linear Models , Reproducibility of Results , Sensitivity and Specificity , Taq Polymerase
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