[Reparative osteogenesis of tubular bones in the conditions of violation of water-salt exchange].

The purpose of the article was to study the bone reparative regeneration in disorders caused by the dehydration of organism. Studies were conducted on 72 white laboratory young male rats. The structural and metabolic displays of reparative osteogenesis were studied by means of histological research of defected area, morphometry of histological preparations by means of the computer programs "Video Test 5,0" and "Video size 5,0". Quantitative disorders of regenerated cellular composition were found on the 3-rd day. Atypical granulation tissue was found on the 15-th day. The delay of regeneration - on the 24th day. It was concluded that the inhibition of reparative osteogenesis occurred under the influence of dehydration. The strongest impact on the process of bone regeneration was caused by an extracellular dehydration.

[Structural and functional changes of cell membranes in patients with renocardiac chronic syndrome].

The 53 patients with chronic renocardiac syndrome, with hypertension in chronic kidney disease, were investigated. In the presence of chronic renal failure there is a decrease of cholesterol in the membrane, which is the basis for the violation liquid characteristics of cell membranes. Changes in the exchange of phospholipids and an increase in the exchange rate reflect increasing phosphatidylcholine lipid peroxidation, increasing in chronic renal failure. The degradation of cell membranes reflects a compensatory accumulation in these fractions of phosphatidylcholine, a major component of the outer layer of biomembranes. Regardless of the degree of renal dysfunction and clinical manifestations of the disease in the membranes of platelets accumulate lizoform phospholipids, indicating a strengthening of the processes of lipid peroxidation and accumulation of biologically active substances, which have membrane-destructive activity.