1.
Bull Exp Biol Med
; 164(4): 569-575, 2018 Mar.
Article
in English
| MEDLINE
| ID: mdl-29504105
ABSTRACT
We analyzed previously generated stable monocyte-derived cell line carrying mutation JAK2 V617F. Evaluation of the expression of pro- and antifibrotic factors revealed changes in the production of MMPs and their inhibitors, growth factors, galectin-3, and pentraxin 3 in cells carrying mutation JAK2 in comparison with control non-modified cells.
Subject(s)
Gene Expression Regulation , Janus Kinase 2/genetics , Mesenchymal Stem Cells/metabolism , Mutation , Blood Proteins , C-Reactive Protein/genetics , C-Reactive Protein/metabolism , Cell Communication , Coculture Techniques , Galectin 3/genetics , Galectin 3/metabolism , Galectins , Humans , Janus Kinase 2/metabolism , Matrix Metalloproteinases/genetics , Matrix Metalloproteinases/metabolism , Mesenchymal Stem Cells/cytology , Models, Biological , Primary Cell Culture , Primary Myelofibrosis/genetics , Primary Myelofibrosis/metabolism , Primary Myelofibrosis/pathology , Protein Isoforms/genetics , Protein Isoforms/metabolism , Serum Amyloid P-Component/genetics , Serum Amyloid P-Component/metabolism , Signal Transduction , THP-1 Cells , Tissue Inhibitor of Metalloproteinases/genetics , Tissue Inhibitor of Metalloproteinases/metabolism
2.
Stomatologiia (Mosk)
; 59(3): 10-1, 1980 Jun.
Article
in Russian
| MEDLINE
| ID: mdl-6930706