ABSTRACT
We present a patient with coccidioidal meningitis whose diagnosis was not confirmed until a skin biopsy was performed. Because he lived in an area where coccidioidomycosis is not endemic, his meningitis was at first attributed to tuberculosis or sarcoidosis. After a verrucous lesion from the face was biopsied and the diagnosis substantiated, the patient responded well to consolidation therapy consisting of intrathecal amphotericin B and oral ketoconazole.
Subject(s)
Coccidioidomycosis/diagnosis , Dermatomycoses/diagnosis , Meningitis/diagnosis , Adult , Amphotericin B/therapeutic use , Coccidioidomycosis/drug therapy , Coccidioidomycosis/pathology , Dermatomycoses/drug therapy , Dermatomycoses/pathology , Humans , Male , Meningitis/drug therapyABSTRACT
Mucous gland adenoma of the bronchus is a truly benign bronchoid neoplasm which responds to simple surgical excision, sparing as much functional lung tissue as possible. The patient here reported is well one year after such treatment.
Subject(s)
Adenoma/pathology , Bronchial Neoplasms/pathology , Adenoma/surgery , Adult , Bronchial Neoplasms/surgery , Female , HumansABSTRACT
A case of dysplastic gangliocytoma of the cerebellum, a rare disorder with unknown etiology and pathogenesis, was studied ultrastructurally. The intranuclear inclusions identified were not seen to be of viral origin. The ultrastructural characteristics of the abnormal cells support the prevailing theory that these cells represent hypertrophied granular neurons.
Subject(s)
Cerebellar Neoplasms/ultrastructure , Ganglioneuroma/ultrastructure , Adult , Cell Nucleus/ultrastructure , Cerebellar Neoplasms/congenital , Ganglioneuroma/congenital , Humans , Inclusion Bodies/ultrastructure , Male , Microscopy, ElectronABSTRACT
A histologic grading system based on tumor differentiation was applied in a retrospective study of 26 patients with Wilms' tumor to determine if it might provide an index to prognosis. The results were compared to those obtained by applying a histologic classification based on the presence or absence of individual histologic structures to the same tumors. Low grade tumors with predominance of differentiated structures--glomeruli and tubules--were associated with a better cure rate than high grade tumors composed mainly of undifferentiated spindle elements. The presence of undifferentiated large cells correlated with poor cure rate. The findings suggest that histologic grading may be valid as a prognostic factor in Wilms' tumor.
Subject(s)
Kidney Neoplasms/pathology , Wilms Tumor/pathology , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Kidney Neoplasms/therapy , Male , Prognosis , Retrospective Studies , Wilms Tumor/therapyABSTRACT
This report concerns an electron microscopic study of a sacrococcygeal chordoma and its in vitro cultured cells. In vitro, the cells that proliferated in the early phase were predominantly non-vacuolated stellate cells, which were later transformed into vacuolated cells. This suggests that various cell types seen in vivo represent variants of the same cell type at different stages of differentiation and cellular activity. The in vitro tumor cells also show the origin of their vacuoles from both rough endoplasmic reticulum and Golgi membranes. The finding of amorphous and granular material and collagen fibrils in the extracellular spaces of cultured cells seems to suggest that chordoma cells have certain synthetic and secretory activity.
Subject(s)
Chordoma/pathology , Sacrococcygeal Region , Cell Differentiation , Chordoma/metabolism , Connective Tissue/ultrastructure , Culture Techniques , Endoplasmic Reticulum/ultrastructure , Golgi Apparatus/ultrastructure , Humans , Male , Microscopy, Phase-Contrast , Middle Aged , Vacuoles/ultrastructureABSTRACT
The electron microscopic features of a leiomyosarcoma occurring in the lung, a rare site, were studied; Unusual was the fwnding of extremely electron-dense bands that interrupted the longitudinally-arranged microfilaments and dense bodies of many of the tumor cells. These bands superficially resembled anomalous Z-bands seen in nemalin myopathy and aging rat cardiac muscle, but have not been described to occur in smooth muscle tumors. They are thought to represent condensations of dense bodies in degenerating tumor cells.
Subject(s)
Leiomyosarcoma/pathology , Lung Neoplasms/pathology , Aged , Humans , Leiomyosarcoma/surgery , Lung/pathology , Lung Neoplasms/surgery , Male , Microscopy, Electron , Mitochondria/ultrastructure , Muscle, Smooth/pathology , Myofibrils/ultrastructure , Organoids/ultrastructure , Staining and LabelingABSTRACT
The electron microscopic features of a leiomyosarcoma occurring in the lung, a rare site, were studied. Unusual was the finding of extremely electron-dense bands that interrupted the longitudinally-arranged microfilaments and dense bodies of many of the tumor cells. The bands superficially resembled anomalous Z-bands seen in nemalin myopathy and aging rat cardiac muscle, but have not been described to occur in smooth muscle tumors. They are thought to represent condensations of dense bodies in degenerating tumor cells.
